Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Intracellular pH.

1981 • 2,440 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Metabolic regulation via intracellular pH

1984 • 674 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2

1985 • 660 citations

Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase

1966 • 647 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

Calcium Rises Abruptly and Briefly Throughout the Cell at the Onset of Anaphase

1986 • 541 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Three-dimensional architecture of a polytene nucleus

1983 • 453 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport.

1984 • 354 citations

Probing the structure of cytoplasm.

1986 • 328 citations

A method for incorporating macromolecules into adherent cells.

1984 • 307 citations

Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.

1982 • 282 citations

Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6.

1984 • 275 citations

Transport of H+ and of ionic weak acids and bases

1983 • 271 citations

Localization and Kinetics of Reduced Pyridine Nucleotide in Living Cells by Microfluorometry

1959 • 251 citations

Activation of Na+/H+ exchange by epidermal growth factor elevates intracellular pH in A431 cells.

1983 • 230 citations

Fluorescence Techniques in Cell Biology

1973 • 228 citations

Intracellular Free Calcium Localization in Neutrophils During Phagocytosis

1985 • 217 citations

The contractile basis of amoeboid movement: V. The control of gelation, solation, and contraction in extracts from dictyostelium discoideum

1977 • 199 citations

Fluorescently labelled molecules as probes of the structure and function of living cells

1980 • 189 citations

pH in the endosome

1984 • 176 citations

Mechanisms and Consequences of pH-Mediated Cell Regulation

1986 • 172 citations

Fluorescence Digital Imaging Microscopy in Cell Biology

1985 • 172 citations

Characteristics of fluoroprobes for measuring intracellular pH

1986 • 169 citations

Digital imaging fluorescence microscopy: spatial heterogeneity of photobleaching rate constants in individual cells.

1985 • 168 citations

Local cytoplasmic calcium gradients in living mitotic cells

1985 • 162 citations

The regulation of cytoplasmic pH in human fibroblasts.

1984 • 157 citations

Rapid acidification of endocytic vesicles containing asialoglycoprotein in cells of a human hepatoma line.

1983 • 155 citations

Platelet-derived growth factor stimulates Na+/H+ exchange and induces cytoplasmic alkalinization in NR6 cells.

1983 • 145 citations

Fluorescein conjugates as indicators of subcellular pH

1984 • 144 citations

Dual ionic controls for the activation of protein synthesis at fertilization

1980 • 143 citations

Microspectrofluorometry by digital image processing: measurement of cytoplasmic pH.

1984 • 133 citations

Flow cytometric measurement of cytoplasmic pH: A critical evaluation of available fluorochromes

1986 • 122 citations

Spreading of human neutrophils is immediately preceded by a large increase in cytoplasmic free calcium.

1986 • 121 citations

Microtubule assembly and disassembly at alkaline pH

1981 • 121 citations

A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate.

1985 • 121 citations

Intracellular pH mediates action of insulin on glycolysis in frog skeletal muscle

1982 • 117 citations

Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells.

1986 • 103 citations

Light: Physical and Biological Action

1966 • 99 citations

Optical measurements of intracellular pH in single LLC-PK1 cells: demonstration of Cl-HCO3 exchange.

1986 • 93 citations

Mitogen‐independent activation of Na⁺/H⁺ exchange in human epidermoid carcinoma A431 cells: Regulation by medium osmolarity

1985 • 92 citations

Fast intracellular pH determination in single cells by flow-cytometry

1981 • 89 citations

�ber die Rolle der Desoxyribosenukleins�ure bei der Zellteilung

1939 • 83 citations

Acidification of phagosomes is initiated before lysosomal enzyme activity is detected.

1983 • 75 citations

Fluorescent analog cytochemistry

1984 • 73 citations

Fc-receptor-mediated phagocytosis occurs in macrophages without an increase in average [Ca++]i.

1986 • 69 citations

Intracellular pH in single motile cells.

1980 • 69 citations

Fluorescence emission spectroscopy of 1,4-dihydroxyphthalonitrile. A method for determining intracellular pH in cultured cells

1985 • 67 citations

A calcium‐ and pH‐regulated actin binding protein from D. discoideum

1982 • 64 citations

Behavior of a fluorescent analogue of calmodulin in living 3T3 cells.

1985 • 63 citations

Measurement of cytoplasmic pH in Dictyostelium discoideum by using a new method for introducing macromolecules into living cells.

1986 • 63 citations

Intracellular pH-determination by fluorescence measurements.

1979 • 62 citations

Direct measurement of lateral transport in membranes by using time-resolved spatial photometry.

1985 • 61 citations

pH changes in pinosomes and phagosomes in the ameba, Chaos carolinensis.

1982 • 53 citations

Image Intensification Applied to Light Microscopy

1980 • 44 citations

The role of increased proteolysis in the atrophy and arrest of proliferation in serum‐deprived fibroblasts

1984 • 36 citations

Analysis of molecular distribution in single cells using a digital imaging microscope.

1986 • 28 citations

An optical technique for measurement of intracellular pH in single living cells.

1981 • 24 citations

Multichannel microspectrofluorometry for topographic and spectral analysis of NAD(P)H fluorescence in single living cells

1975 • 23 citations

Intracellularly trapped pH indicators.

1986 • 21 citations

LOCALIZATION OF INTRACELLULAR AND INTRAMITOCHONDRIAL COMPARTMENTS

1963 • 18 citations

Measurement of fluorescence using digital integration of video images.

1984 • 18 citations

Spectrophotometric measurements of metabolically induced pH changes in frog skeletal muscle

1977 • 18 citations

Microspectrofluorometric Procedures and Their Applications in Biological Systems

1981 • 13 citations

New instrumentation for sensitive image analysis of fluorescence in cells and tissues

1986 • 12 citations

A Microspectrofluorometer for Measuring Spectra of Excitation, Emission and Absorption in Cells and Tissues

1973 • 5 citations

Early Cytoplasmic Signals and Cytoskeletal Responses Initiated by Growth Factors in Cultured Cells

1987 • 5 citations