Candidate Genes in Breast Cancer Revealed by Microarray-Based Comparative Genomic Hybridization of Archived Tissue

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

1998 • 2,266 citations

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

1997 • 1,655 citations

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors

1994 • 1,047 citations

Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances

1997 • 991 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

A tiling resolution DNA microarray with complete coverage of the human genome

2004 • 644 citations

Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene

2000 • 598 citations

DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.

1998 • 583 citations

Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability/mental retardation and dysmorphic features

2004 • 509 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

DNA microarrays for comparative genomic hybridization based on DOP‐PCR amplification of BAC and PAC clones

2003 • 480 citations

The ErbB/HER receptor protein-tyrosine kinases and cancer

2004 • 390 citations

High Frequency of Multiple Melanomas and Breast and Pancreas Carcinomas in CDKN2A Mutation-Positive Melanoma Families

2000 • 344 citations

Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.

2003 • 329 citations

Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.

1992 • 322 citations

Quantitative analysis of comparative genomic hybridization

1995 • 304 citations

Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer.

1995 • 302 citations

Positional cloning of ZNF 217 and NABC 1 : Genes amplified at 20q13.2 and overexpressed in breast carcinoma

1998 • 296 citations

C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance

2000 • 295 citations

Detecting Activation of Ribosomal Protein S6 Kinase by Complementary DNA and Tissue Microarray Analysis

2000 • 280 citations

Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.

2003 • 260 citations

Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer

2001 • 259 citations

Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations

2004 • 241 citations

Minimal sizes of deletions detected by comparative genomic hybridization

1998 • 230 citations

Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas.

1995 • 230 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.

2000 • 197 citations

Gene amplification and tumor progression

1993 • 172 citations

Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis.

2000 • 162 citations

High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization

2004 • 151 citations

Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations.

2000 • 149 citations

Comparative genomic hybridization: Uses and limitations

2000 • 122 citations

Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma.

1988 • 112 citations

Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer†

2002 • 112 citations

Patterns of chromosomal imbalances in invasive breast cancer

2000 • 100 citations

Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer.

1999 • 99 citations

Automated Screening for Genomic Imbalances using Matrix-Based Comparative Genomic Hybridization

2002 • 99 citations

17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes.

2000 • 94 citations

Association between female breast cancer and cutaneous melanoma

2004 • 85 citations

The ErbB/HER receptor protein-tyrosine kinases and cancer*1

2004 • 79 citations

Comparative genomic hybridisation for the analysis of chromosomal imbalances in solid tumours and haematological malignancies

1997 • 78 citations

Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade

2004 • 78 citations

Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma

2004 • 77 citations

Comparative genomic hybridization in the investigation of myeloid leukemias

1995 • 64 citations

Wild Type p73 Overexpression and High-Grade Malignancy in Breast Cancer

2001 • 57 citations

Loss of heterozygosity of BRCA1, BRCA2 and ATM genes in sporadic invasive ductal breast carcinoma.

1998 • 53 citations

Structural analysis of the 17q22-23 amplicon identifies several independent targets of amplification in breast cancer cell lines and tumors.

2001 • 51 citations

Amplification of c-myc by Fluorescence In Situ Hybridization in a Population-Based Breast Cancer Tissue Array

2001 • 46 citations

Allelic loss of theBRCA1 andBRCA2 genes and other regions on 17q and 13q in breast cancer among women from Taiwan (area of low incidence but early onset)

1998 • 46 citations

Clinical relevance of genomic aberrations in homogeneously treated high-risk stage II/III breast cancer patients

2001 • 38 citations

Genomic loss of 18p predicts an adverse clinical outcome in patients with high-risk breast cancer.

2002 • 37 citations

Comparative genomic hybridization: Uses and limitations

2000 • 15 citations