Biased dependency of CD80 versus CD86 in the induction of transcription factors regulating the human IL-2 promoter

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

1995 • 489 citations

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

1989 • 487 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

1995 • 358 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.

1991 • 335 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond

1996 • 148 citations

p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells.

1993 • 139 citations

Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy.

1994 • 121 citations

Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L.

1997 • 94 citations

Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation.

1992 • 64 citations

Human T cell clones exerting multiple cytolytic activities show heterogeneity in susceptibility to inhibition by monoclonal antibodies.

1984 • 54 citations

A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells.

1991 • 52 citations

Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.

1994 • 43 citations

Differential requirements for co-stimulatory signals from B7 family members by resting versus recently activated memory T cells towards soluble recall antigens

1996 • 42 citations

Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody.

1993 • 42 citations

Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals

1992 • 38 citations

Costimulation by B7-1 and LFA-3 Targets Distinct Nuclear Factors That Bind to the Interleukin-2 Promoter: B7-1 Negatively Regulates LFA-3-Induced NF-AT DNA Binding

1997 • 30 citations

Regulation of superantigen-induced T cell activation in the absence and the presence of MHC class II.

1996 • 29 citations

Alloantigen-induced human lymphocytes rendered nonresponsive by a combination of anti-CD80 monoclonal antibodies and cyclosporin-A suppress mixed lymphocyte reaction in vitro.

1995 • 28 citations

B7-CD28 interaction is a late acting co-stimulatory signal for human T cell responses

1997 • 24 citations

The LFA-3 Adhesion Pathway is Differently Utilized by Superantigen-Activated Human CD4+ T-Cell Subsets

1992 • 19 citations

Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.

1993 • 19 citations

Differential signal requirements in T-cell activation by mitogen and superantigen

1990 • 16 citations

COSTIMULATION REGULATES THE KINETICS OF interleukin‐2 RESPONSE TO BACTERIAL SUPERANTIGENS

1996 • 15 citations

The IL-2/IL-2 Receptor System. Involvement of a Novel Receptor Subunit, .GAMMA. Chain, in Growth Signal Transduction.

1992 • 13 citations

Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors.

1995 • 11 citations