Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

2002 • 1,295 citations

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1993 • 1,119 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

2004 • 788 citations

Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes

2004 • 718 citations

Enhancing Incretin Action for the Treatment of Type 2 Diabetes

2003 • 578 citations

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26

2000 • 540 citations

Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts

1999 • 521 citations

Twelve- and 52-Week Efficacy of the Dipeptidyl Peptidase IV Inhibitor LAF237 in Metformin-Treated Patients With Type 2 Diabetes

2004 • 496 citations

CD26, let it cut or cut it down

1999 • 454 citations

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

2003 • 341 citations

Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes

2004 • 277 citations

Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8

2000 • 269 citations

Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide

1998 • 260 citations

Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats

2002 • 237 citations

Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats

1999 • 212 citations

Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?

2004 • 191 citations

Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat

2002 • 144 citations

Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions

1998 • 143 citations

Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity

2004 • 134 citations

Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities?

2001 • 129 citations

Sequence, Purification, and Cloning of an Intracellular Serine Protease, Quiescent Cell Proline Dipeptidase

1999 • 97 citations

Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8

2004 • 92 citations

The Role of Dipeptidyl Peptidase IV (DP IV) Enzymatic Activity in T Cell Activation and Autoimmunity

2002 • 71 citations

DPPIV, seprase, and related serine peptidases in multiple cellular functions

2003 • 53 citations

Potent and selective proline derived dipeptidyl peptidase IV inhibitors

2004 • 53 citations

Dipeptidyl‐peptidase IV‐β

1998 • 27 citations

METABOLISM AND PHARMACOKINETICS OF A DIPEPTIDYL PEPTIDASE IV INHIBITOR IN RATS, DOGS, AND MONKEYS WITH SELECTIVE CARBAMOYL GLUCURONIDATION OF THE PRIMARY AMINE IN DOGS

2003 • 22 citations

Inhibition of dipeptidyl peptidase IV (DP IV) in rat results in improved glucose tolerance

1996 • 16 citations