Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia

1965 • 1,213 citations

Gene amplification in cultured animal cells

1984 • 639 citations

A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis

1989 • 234 citations

The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization procedures

1984 • 228 citations

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.

1980 • 215 citations

An Isotopic Assay for Thymidylate Synthetase^*

1966 • 212 citations

Radioactive assay for serine transhydroxymethylase

1965 • 209 citations

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates.

1984 • 145 citations

Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity.

1993 • 134 citations

Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes

1981 • 120 citations

Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.

1988 • 110 citations

Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

1991 • 104 citations

Amplification of a Polymorphic Dihydrofolate Reductase Gene Expressing an Enzyme with Decreased Binding to Methotrexate in a Human Colon Carcinoma Cell Line, HCT-8R4, Resistant to This Drug

1989 • 101 citations

Radioactive assay of folic acid polyglutamate conjugase(s)

1970 • 83 citations

Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.

1988 • 82 citations

Filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant

1974 • 80 citations

Purification and Properties of the Formate-activating Enzyme from Erythrocytes

1962 • 75 citations

On the purification and mechanism of action of 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase from chicken liver

1981 • 60 citations

Optimal extraction conditions for high-performance liquid chromatographic determination of nucleotides in yeast

1984 • 51 citations

Comparison of folylpolyglutamate hydrolases of mouse liver, kidney, muscle and brain

1982 • 50 citations

gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.

1985 • 46 citations

Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.

1986 • 45 citations

Intracellular metabolism of 5,10-dideazatetrahydrofolic acid in human leukemia cell lines.

1991 • 39 citations

(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid effects on nucleotide metabolism in CCRF-CEM human T-lymphoblast leukemia cells.

1991 • 24 citations

Inhibition of mannose incorporation into glycoproteins and dolichol‐linked intermediates of sarcoma 180 cells by 6‐methylmercaptopurine ribonucleoside

1987 • 18 citations

Characterization of mammalian phosphoribosylglycineamide formyltransferase from transformed cells.

1985 • 16 citations

Determination of mouse liver 5-methyltetrahydrofolate concentration and polyglutamate forms

1985 • 16 citations

Enzymatic Determination of Tissue Dihydrofolate

1984 • 12 citations

Inhibition of serine metabolism by tetrahydrohomofolate in L1210 mouse leukemia cells.

1981 • 12 citations

A sensitive radioenzymatic assay for (S)-5-formyltetrahydrofolate

1991 • 8 citations

Biochemical pharmacology of deazatetrahydrofolates

1990 • 4 citations