Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

The Statistical Analysis of Enzyme Kinetic Data

1967 • 1,068 citations

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

1969 • 779 citations

Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.

1982 • 737 citations

A linear equation that describes the steady-state kinetics of enzymes and subcellular particles interacting with tightly bound inhibitors

1972 • 524 citations

Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

1961 • 389 citations

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

1985 • 312 citations

ZONE BEHAVIOR OF ENZYMES

1943 • 235 citations

A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis

1989 • 234 citations

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

1978 • 229 citations

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

1985 • 150 citations

The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

1986 • 140 citations

Folate metabolism in mammalian cells in culture. I Partial characterization of the folate derivatives present in L1210 mouse leukemia cells.

1976 • 116 citations

Studies with a mathematical model of folate metabolism

1973 • 116 citations

The 6S- and 6R-Diastereomers of 5, 10-Dideaza-5, 6, 7, 8-tetrahydrofolate Are Equiactive Inhibitors of de Novo Purine Synthesis

1989 • 100 citations

Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics.

1979 • 78 citations

Purification of mammalian tumor (L1210) thymidylate synthetase by affinity chromatography on stable biospecific adsorbent. Stabilization of the enzyme with neutral detergents.

1979 • 64 citations

Formation and retention and biological activity of N10-propargyl-5, 8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro

1988 • 63 citations

Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency

1989 • 63 citations

l(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver

1981 • 62 citations

Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.

1986 • 45 citations

Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids

1977 • 44 citations

Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs

1989 • 44 citations

Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis

1986 • 38 citations

A new chemical synthesis of 2-amino-(N-d-ribofuranosyl)acetamide 5′-phosphate

1977 • 37 citations

Mammalian Glycinamide Ribonucleotide Transformylase

1989 • 32 citations

An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver

1984 • 29 citations

A simple procedure for the synthesis of high specific activity tritiated (6S)-5-formyltetrahydrofolate

1982 • 27 citations

Mammalian glycinamide ribonucleotide transformylase: purification and some properties

1985 • 25 citations

Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo.

1989 • 18 citations

(6R,6S)-5,8,10-Trideaza-5,6,7,8-tetrahydrofolate and (6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-ornithine as potential antifolates and antitumor agents. 35

1989 • 16 citations

Characterization of mammalian phosphoribosylglycineamide formyltransferase from transformed cells.

1985 • 16 citations

Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.

1986 • 15 citations

Characterization of the Function of Mammalian Folylpolyglutamate Synthetase (FPGS)

1983 • 10 citations

The 2-desamino and 2-desamino-2-methyl analogs of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture

1989 • 8 citations

A Convenient Preparation of Tetrahydropteridines and Tetrahydrofolate Analogs. Synthesis of Tetrahydro-3′,5′-Dichloromethotrexate

1980 • 6 citations