Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

1994 • 420 citations

Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors

1983 • 176 citations

A “Distant” Bystander Effect of Suicide Gene Therapy: Regression of Nontransduced Tumors Together with a Distant Transduced Tumor

1997 • 128 citations

Induction of potent antitumor natural killer cell activity by herpes simplex virus-thymidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer.

1998 • 105 citations

Suicide gene therapy for plasma cell tumors

1996 • 68 citations

An HSVtk-mediated local and distant antitumor bystander effect in tumors of head and neck origin in athymic mice.

1997 • 63 citations

Cytosine Deaminase/5-Fluorocytosine-Based Vaccination Against Liver Tumors: Evidence of Distant Bystander Effect

1999 • 46 citations

HSV-tk Gene Therapy in Head and Neck Squamous Cell Carcinoma: Enhancement by the Local and Distant Bystander Effect

1996 • 37 citations

Suicide gene therapy of chemically induced mammary tumor in rat: efficacy and distant bystander effect.

1998 • 35 citations

Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes.

1996 • 30 citations

The Immune Response Elicited by Mammary Adenocarcinoma Cells Transduced with Interferon-γand Cytosine Deaminase Genes Cures Lung Metastases by Parental Cells

1998 • 26 citations

Local and systemic antitumor response after combined therapy of mouse metastatic tumors with tumor cells expressing IFN-α and HSVtk: perspectives for the generation of cancer vaccines

1997 • 22 citations

Antitumoral vaccination with granulocyte-macrophage colony-stimulating factor or interleukin-12-expressing DHD/K12 colon adenocarcinoma cells

2000 • 15 citations

Regression of experimental liver tumor after distant intra-hepatic injection of cytosine deaminase-expressing tumor cells and 5-fluorocytosine treatment.

2000 • 10 citations

F11C antigen: A membrane marker able to distinguish two regressive and progressive variants from a rat colon adenocarcinoma

1990 • 10 citations