IL-10 Suppresses Chemokines, Inflammation, and Fibrosis in a Model of Chronic Renal Disease

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10.

1993 • 657 citations

Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

2002 • 567 citations

IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages

1998 • 505 citations

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

1998 • 442 citations

Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model

1992 • 404 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation

1998 • 379 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor.

1992 • 229 citations

Interleukin-10 suppresses hepatic ischemia/reperfusion injury in mice: Implications of a central role for nuclear factor ?B

1999 • 216 citations

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity

1992 • 210 citations

Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats

1999 • 203 citations

Local Adeno-Associated Virus-Mediated Interleukin 10 Gene Transfer Has Disease-Modifying Effects in a Murine Model of Sjögren's Syndrome

2003 • 191 citations

Glomerular cells, extracellular matrix accumulation, and the development of glomerulosclerosis in the remnant kidney model.

1992 • 190 citations

Role of immunocompetent cells in nonimmune renal diseases

2001 • 187 citations

Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors

2001 • 152 citations

IL-10 Converts Human Dendritic Cells into Macrophage-Like Cells with Increased Antibacterial Activity Against VirulentMycobacterium tuberculosis

2000 • 149 citations

Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice

2001 • 141 citations

Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion

2003 • 132 citations

Immune modulation with interleukin‐4 and interleukin‐10 prevents crescent formation and glomerular injury in experimental glomerulonephritis

1997 • 122 citations

Interleukin-10 Inhibits Intimal Hyperplasia After Angioplasty or Stent Implantation in Hypercholesterolemic Rabbits

2000 • 119 citations

Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney

2000 • 116 citations

Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice

1997 • 97 citations

Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice

2003 • 95 citations

Dimeric galectin‐1 induces IL‐10 production in T‐lymphocytes: an important tool in the regulation of the immune response

2004 • 94 citations

Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis

2000 • 80 citations

The Impact of Gender on Progression of Renal Disease

2004 • 77 citations

Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice

2004 • 76 citations

Interferon-γ Augments Acute Macrophage-Mediated Renal Injury Via a Glucocorticoid-Sensitive Mechanism

2003 • 73 citations

Interleukin-10 Inhibits Human Vascular Smooth Muscle Proliferation

1998 • 60 citations

IL-10 inhibits vascular smooth muscle cell activation in vitro and in vivo

2004 • 60 citations

Macrophage-colony-stimulating factor expression by anti-CD45 stimulated human monocytes is transcriptionally up-regulated by IL-1 beta and inhibited by IL-4 and IL-10.

1994 • 55 citations

Focal glomerulosclerosis in the remnant kidney model--an inflammatory disease mediated by cytokines

1997 • 53 citations

Suppression of glomerulosclerosis by adenovirus-mediated IL-10 expression in the kidney

2003 • 52 citations

Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis

2002 • 50 citations

Recombinant adeno-associated virus vectors for gene therapy

2004 • 46 citations

Interleukin-10 attenuates the response to vascular injury1,2

2004 • 45 citations

Presence of Diabetes-Inhibiting, Glutamic Acid Decarboxylase-Specific, IL-10-Dependent, Regulatory T Cells in Naive Nonobese Diabetic Mice

2004 • 42 citations

Regulation of interleukin-2 and interferon-γ gene expression in renal failure

1991 • 37 citations

Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats

2004 • 28 citations

Interleukin-10 and its implications for immunopathology.

1995 • 24 citations

Adherence modifies the regulation of gene expression induced by interleukin-10

2004 • 24 citations

Expression of monocyte chemoattractant protein-1 in proximal tubular epithelial cells in a rat model of progressive kidney failure

2002 • 20 citations

Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts

1994 • 17 citations

Deleted Work

1955 • 0 citations