A P‐loop‐like motif in a widespread ATP pyrophosphatase domain: Implications for the evolution of sequence motifs and enzyme activity

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Nucleotide sequence of bacteriophage λ DNA

1982 • 1,171 citations

A workbench for multiple alignment construction and analysis

1991 • 1,005 citations

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.

1992 • 805 citations

Issues in searching molecular sequence databases

1994 • 781 citations

Statistics of local complexity in amino acid sequences and sequence databases

1993 • 735 citations

A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 Å

1990 • 620 citations

A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication

1993 • 400 citations

Convergent evolution of similar enzymatic function on different protein folds: The hexokinase, ribokinase, and galactokinase families of sugar kinases

1993 • 393 citations

The functions and consensus motifs of nine types of peptide segments that form different types of nucleotide‐binding sites

1994 • 388 citations

Convergent evolution: the need to be explicit

1994 • 367 citations

The ENZYME data bank.

1994 • 345 citations

A Superfamily of ATPases with Diverse Functions Containing Either Classical or Deviant ATP-binding Motif

1993 • 322 citations

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

1994 • 286 citations

Binding of nucleotides by proteins

1992 • 274 citations

X-ray structure of nucleoside diphosphate kinase.

1992 • 191 citations

Using Dirichlet mixture priors to derive hidden Markov models for protein families.

1993 • 170 citations

ATP sulphurylase activity of the nodP and nodQ gene products of Rhizobium meliloti

1990 • 147 citations

The SWISS-PROT protein sequence data bank, recent developments

1993 • 147 citations

The aminoacyl‐tRNA synthetase family: Modules at work

1993 • 146 citations

Evolutionarily Mobile Modules in Proteins

1993 • 136 citations

Evolution and relatedness in two aminoacyl-tRNA synthetase families.

1991 • 127 citations

A new family of carbon‐nitrogen hydrolases

1994 • 115 citations

Yeast chromosome III: new gene functions.

1994 • 104 citations

The DNA sequence of the sulfate activation locus from Escherichia coli K-12.

1992 • 87 citations

Gene-enzyme relationship in the sulfate assimilation pathway of Saccharomyces cerevisiae. Study of the 3'-phosphoadenylylsulfate reductase structural gene.

1990 • 74 citations

Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase.

1985 • 72 citations

Cloning and sequence of Bacillus subtilis purA and guaA, involved in the conversion of IMP to AMP and GMP

1992 • 62 citations

Fibronectin type III modules in the receptor phosphatase CD45 and tapeworm antigens

1993 • 49 citations

Biochemical genetics revisited: the use of mutants to study carbon and nitrogen metabolism in the photosynthetic bacteria

1993 • 49 citations

The ENZYME data bank

1993 • 45 citations

Unexpected sequence similarity between nucleosidases and phosphoribosyltransferases of different specificity

1994 • 35 citations

Sequence analysis of firefly luciferase family reveals a conservative sequence motif.

1991 • 30 citations

A fast, sensitive pattern-matching approach for protein sequences

1993 • 27 citations

GTPase Activation of ATP Sulfurylase: The Mechanism

1994 • 27 citations

Mutational analysis of the structure and function of the adenine phosphoribosyltransferase enzyme of Chinese hamster

1991 • 26 citations

Preliminary x‐ray analysis of Escherichia coli GMP synthetase: Determination of anomalous scattering factors for a cysteinyl mercury derivative

1994 • 22 citations

The Bacillus subtilis outB gene is highly homologous to an Escherichia coli ntr-like gene

1990 • 20 citations

Nucleotide sequence of the outB locus of Bacillus subtilis and regulation of its expression

1987 • 19 citations

Mutational analysis of the structure and function of the adenine phosphoribosyltransferase enzyme of Chinese hamster

1991 • 9 citations

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