TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Molecular Basis of T Cell Inactivation by CTLA-4

1998 • 678 citations

Reversal of the TCR Stop Signal by CTLA-4

2006 • 584 citations

B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse

2004 • 415 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

2003 • 368 citations

Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

2004 • 354 citations

Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

1995 • 347 citations

The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A

2000 • 287 citations

Structural Analysis of CTLA-4 Function In Vivo

2000 • 236 citations

In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance

2005 • 145 citations

Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function

2001 • 136 citations

CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function

2005 • 120 citations

Mechanisms of CTLA-4-Ig in Tolerance Induction

2005 • 61 citations

Modeling CTLA4 -linked autoimmunity with RNA interference in mice

2006 • 47 citations

CTL-Associated Antigen-4 Ligation Induces Rapid T Cell Polarization That Depends on Phosphatidylinositol 3-Kinase, Vav-1, Cdc42, and Myosin Light Chain Kinase

2007 • 26 citations