TUMOUR NECROSIS FACTOR ALPHA AND ITS SOLUBLE RECEPTORS PARALLEL CLINICAL DISEASE AND AUTOIMMUNE ACTIVITY IN SYSTEMIC LUPUS ERYTHEMATOSUS

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

Immune Interferon in the Circulation of Patients with Autoimmune Disease

1979 • 907 citations

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 • 832 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.

1994 • 543 citations

Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis.

1991 • 540 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity

1989 • 442 citations

Serum interferon levels in patients with systemic lupus erythematosus

1982 • 376 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes.

1995 • 328 citations

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis.

1988 • 321 citations

Purification and biologic characterization of a specific tumor necrosis factor α inhibitor

1989 • 294 citations

Elevated levels of interleukin‐6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system invol vement

1990 • 272 citations

Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury.

1989 • 255 citations

Interleukin 6 promotes murine lupus in NZB/NZW F1 mice.

1994 • 239 citations

Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group.

1992 • 203 citations

Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus

1993 • 177 citations

Soluble interleukin‐2 receptors in systemic lupus erythematosus

1988 • 170 citations

Chronic therapy with recombinant tumor necrosis factor-α in autoimmune NZB/NZW F1 mice

1989 • 169 citations

Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus.

1988 • 162 citations

Genetics of tumour necrosis factor-alpha in autoimmune, infectious, and neoplastic diseases.

1995 • 153 citations

Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. III. Development of a computerised clinical chart and its application to the comparison of different indices of disease activity. The European Consensus Study Group for Disease Activity in SLE.

1992 • 152 citations

Tumor necrosis factor in the serum of patients with systemic lupus erythematosus

1989 • 149 citations

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

1994 • 144 citations

Soluble tumor necrosis factor receptors in human inflammatory synovial fluids

1993 • 129 citations

Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression

1992 • 125 citations

Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus.

1993 • 115 citations

Plasma concentration of IL-6 in systemic lupus erythematosus; an indicator of disease activity?

1992 • 108 citations

Selective up-regulation of the 75-kDa tumor necrosis factor (TNF) receptor and its mRNA by TNF and IL-1.

1993 • 98 citations

Cytokine abnormalities in human lupus

1992 • 93 citations

Absence of correlation between interleukin 6 and C-reactive protein blood levels in systemic lupus erythematosus compared with rheumatoid arthritis.

1993 • 80 citations

Soluble receptors for tumor necrosis factor and interleukin-2 in serum and synovial fluid of patients with rheumatoid arthritis, reactive arthritis and osteoarthritis.

1995 • 70 citations

Changes in plasma levels of interleukin-2 receptor in relation to disease exacerbations and levels of anti-dsDNA and complement in systemic lupus erythematosus

1990 • 66 citations

Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.

1995 • 52 citations

Glomerular basement membrane-containing immune complexes stimulate tumor necrosis factor and interleukin-1 production by human monocytes.

1989 • 38 citations

Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells

1993 • 37 citations

MHC class II-associated variation in the production of tumor necrosis factor in mice and humans: Relevance to the pathogenesis of autoimmune diseases

1991 • 26 citations

Cytokine measurements in body fluids.

1990 • 26 citations

Immunologic abnormality in NZB/W Fl mice. Thymus-independent expansion of B cells responding to interleukin-6

1990 • 23 citations

Preliminary report on cytokine determination in human synovial fluids: a consensus study of the European Workshop for Rheumatology Research. The Cytokine Consensus Study Group of the European Workshop for Rheumatology Research.

1992 • 22 citations

Concepts of pathogenesis of systemic lupus erythematosus

1992 • 20 citations

Cytokines—Protein Structure and Biological Activity: A Complex Relationship with Implications for Biological Assays and Standardization

1993 • 18 citations

Cytokine Combinations Increase p75 Tumor Necrosis Factor Receptor Binding and Stimulate Receptor Shedding in Rheumatoid Synovial Fibroblasts

1994 • 15 citations