The Role of Endogenous Interleukin-1 in Stress-Induced Adrenal Activation and Adrenalectomy-Induced Adrenocorticotropic Hormone Hypersecretion

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*

1991 • 1,690 citations

Interleukin-1 Stimulates the Secretion of Hypothalamic Corticotropin-Releasing Factor

1987 • 1,512 citations

Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

1996 • 1,477 citations

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

1999 • 1,254 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Corticotropin-Releasing Factor-Producing Neurons in the Rat Activated by Interleukin-1

1987 • 1,152 citations

Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor

1986 • 874 citations

Interleukin 1 in the brain: biology, pathology and therapeutic target

2000 • 673 citations

Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells

1987 • 670 citations

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

1998 • 604 citations

Catecholaminergic Modulation of Corticotropin-Releasing Factor and Adrenocorticotropin Secretion

1989 • 536 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

1998 • 452 citations

Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.

1997 • 330 citations

Systematic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone

1988 • 300 citations

Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus

1993 • 293 citations

Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat

1995 • 246 citations

Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study

1995 • 236 citations

Interleukin-1 β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

1990 • 233 citations

Effects of Cytokines on Glucocorticoid Receptor Expression And Function

1999 • 200 citations

Limbic pathways and hypothalamic neurotransmitters mediating adrenocortical responses to neural stimuli

1995 • 184 citations

The involvement of serotonin in regulation of pituitary-adrenocortical function.

1992 • 181 citations

Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons

1999 • 142 citations

Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1β protein response to acute stress

2000 • 142 citations

Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide

1996 • 126 citations

Noradrenergic Innervation of the Hypothalamus Participates in Adrenocortical Responses to Interleukin-1

1992 • 120 citations

Corticosteroid Feedback Control of ACTH Secretion: Rapid Effects of Bilateral Adrenalectomy on Plasma ACTH in the Rat1

1972 • 106 citations

Evidence for the involvement of the central adrenergic system in interleukin l-induced adrenocortical response

1989 • 105 citations

Release of ciliary neurotrophic factor from cultured astrocytes and its modulation by cytokines

1995 • 59 citations

Acute-phase responses in transgenic mice with CNS overexpression of IL-1 receptor antagonist

1999 • 58 citations

Central catecholaminergic system stimulates secretion of CRH at different sites

1988 • 58 citations

Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions.

1997 • 50 citations

Effect of Interleukin-1 on ACTH and Corticosterone Secretion in Dexamethasone and Adrenalectomized Pretreated Male Rats

1989 • 48 citations

Characterization of the 2-deoxyglucose effect on the adrenocortical axis.

1994 • 45 citations

Effects of Bacterial Endotoxin on the Glucocorticoid Feedback Regulation of Adrenocortical Response to Stress

1996 • 42 citations

A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis

2001 • 33 citations

The role of brain cytokines in mediating the behavioral and neuroendocrine effects of intracerebral Mycoplasma fermentans

1999 • 28 citations

Modulation of Interleukin-1 Receptors in the Brain-Endocrine-Immune Axis by Stress and Infection

1995 • 17 citations

Effect of hypothalamic norepinephrine depletion on median eminence CRF-41 content and serum ACTH in control and adrenalectomized rats

1991 • 15 citations

Acute Effects of Purified and UV-Inactivated Herpes simplex Virus Type 1 on the Hypothalamo-Pituitary-Adrenocortical Axis

2001 • 13 citations

Effect of non-peptide corticotropin-releasing factor receptor type 1 antagonist on adrenocorticotropic hormone release and interleukin-1 receptors followed by stress

2001 • 12 citations