Construction and characterization of a bispecific diabody for retargeting T cells to human carcinomas

Making antibody fragments using phage display libraries

1991 • 1,195 citations

"Diabodies": small bivalent and bispecific antibody fragments.

1993 • 861 citations

Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma

1994 • 647 citations

A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity.

1995 • 337 citations

Preparation and performance of bispecific F(ab' gamma)2 antibody containing thioether-linked Fab' gamma fragments.

1987 • 267 citations

Engineered turns of a recombinant antibody improve its in vivo folding

1995 • 238 citations

Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers

1996 • 201 citations

High level production of soluble single chain antibodies in small-scale Escherichia coli cultures

1997 • 198 citations

Crystal structure of a diabody, a bivalent antibody fragment

1994 • 190 citations

Construction and Characterization of a Set of E. coli Strains Deficient in All Known Loci Affecting the Proteolytic Stability of Secreted Recombinant Proteins

1994 • 140 citations

High Level Secretion of a Humanized Bispecific Diabody from Escherichia coli

1996 • 125 citations

Multivalent Fvs: characterization of single-chain Fv oligomers and preparation of a bispecific Fv

1994 • 113 citations

SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2

1994 • 108 citations

Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody

1996 • 96 citations

Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris

1997 • 94 citations

Phase I clinical comparative study of monoclonal antibody KS1/4 and KS1/4-methotrexate immunconjugate in patients with non-small cell lung carcinoma.

1990 • 85 citations

Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2

1994 • 85 citations

Phage diabody repertoires for selection of large numbers of bispecific antibody fragments

1996 • 74 citations

Identification of heavy chain residues in a humanized anti-CD3 antibody important for efficient antigen binding and T cell activation.

1995 • 35 citations

Pharmacokinetics and scintigraphy of indium-111-DTPA-MOC-31 in small-cell lung carcinoma

1996 • 31 citations

Epitope mapping of SCLC-cluster-2 MAbs and generation of antibodies directed against new EGP-2 epitopes

1994 • 24 citations

[Escherichia coli in biotechnology].

1986 • 15 citations

Targeting of peripheral blood T lymphocytes

1996 • 13 citations

Detection of a putative 30-kDa ligand of the cluster-2 antigen

1994 • 11 citations