Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk reduction and number needed to treat

Measuring inconsistency in meta-analyses

2003 • 53,662 citations

An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction

1993 • 3,911 citations

Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

1988 • 2,740 citations

Empirical Evidence of Design-Related Bias in Studies of Diagnostic Tests

1999 • 1,799 citations

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group

1991 • 1,361 citations

A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction

1982 • 1,286 citations

Users' guides to the medical literature : a manual for evidence-based clinical practice

2002 • 1,138 citations

Health Outcomes Associated With Various Antihypertensive Therapies Used as First-Line Agents

2003 • 1,103 citations

Health Outcomes Associated With Antihypertensive Therapies Used as First-Line Agents<subtitle>A Systematic Review and Meta-analysis</subtitle>

1997 • 887 citations

B-Type Natriuretic Peptide and Clinical Judgment in Emergency Diagnosis of Heart Failure

2002 • 878 citations

RANDOMISED TRIAL OF INTRAVENOUS STREPTOKINASE, ORAL ASPIRIN, BOTH, OR NEITHER AMONG 17 187 CASES OF SUSPECTED ACUTE MYOCARDIAL INFARCTION: ISIS-2

1988 • 848 citations

Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting

2001 • 820 citations

Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis

1995 • 488 citations

Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic)

2004 • 468 citations

Measured Enthusiasm: Does the Method of Reporting Trial Results Alter Perceptions of Therapeutic Effectiveness?

1992 • 378 citations

Measures of association

1983 • 377 citations

An evidence based approach to individualising treatment

1995 • 369 citations

The framing effect of relative and absolute risk

1993 • 363 citations

Absolutely relative: How research results are summarized can affect treatment decisions

1992 • 335 citations

Can overall results of clinical trials be applied to all patients?

1995 • 298 citations

Can we individualize the ‘number needed to treat’? An empirical study of summary effect measures in meta-analyses

2002 • 293 citations

Evidence based purchasing: understanding results of clinical trials and systematic reviews

1995 • 216 citations

An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis of clinical trials

1998 • 213 citations

The number needed to treat: a clinically useful nomogram in its proper context

1996 • 197 citations

Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis

1997 • 172 citations

Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results

2005 • 149 citations

When should an effective treatment be used?

2001 • 110 citations

Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. The SALT Collaborative Group.

1991 • 91 citations

Tips for learners of evidence-based medicine: 2. Measures of precision (confidence intervals)

2004 • 76 citations

B‐type Natriuretic Peptide for Diagnosis of Heart Failure in Emergency Department Patients: A Critical Appraisal

2004 • 58 citations

Generalized likelihood ratios for quantitative diagnostic test scores

1997 • 19 citations

Mount Sinai Medical Center

2011 • 19 citations

Four rapid serum-urine combination assays of choriogonadotropin (hCG) compared and assessed for their utility in quantitative determinations of hCG

1994 • 18 citations

Should emergency physicians use B-type natriuretic peptide testing in patients with unexplained dyspnea?

2003 • 16 citations

Effects of tissue-type plasminogen activator and anisoylated plasminogen streptokinase activator complex on mortality in acute myocardial infarction.

1990 • 9 citations

The Albert Einstein College of Medicine

2008 • 8 citations

[Clinical trial of 2 highly sensitive pregnancy tests--Tandem ICON HCG-urine and OPCO One-step Pacific Biotech].

1992 • 2 citations