RANDOMISED TRIAL OF INTRAVENOUS STREPTOKINASE, ORAL ASPIRIN, BOTH, OR NEITHER AMONG 17 187 CASES OF SUSPECTED ACUTE MYOCARDIAL INFARCTION: ISIS-2

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION

1986 • 2,315 citations

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

1987 • 2,245 citations

Secondary prevention of vascular disease by prolonged antiplatelet treatment

1988 • 962 citations

RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1985 • 756 citations

Stein's Paradox in Statistics

1977 • 734 citations

A Prospective Trial of Intravenous Streptokinase in Acute Myocardial Infarction (I.S.A.M.)

1986 • 705 citations

Why do we need some large, simple randomized trials?

1984 • 692 citations

Effect of Intravenous Streptokinase on Left Ventricular Function and Early Survival after Acute Myocardial Infarction

1987 • 628 citations

Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials

1985 • 578 citations

Thrombolytic Therapy: Current Status

1988 • 556 citations

Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1

1987 • 504 citations

Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

1988 • 441 citations

Clinical pharmacology of platelet cyclooxygenase inhibition.

1985 • 432 citations

United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: interim results

1988 • 374 citations

Intravenous short-term infusion of streptokinase in acute myocardial infarction.

1983 • 368 citations

The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Randomized Trial.

1988 • 246 citations

Thrombolytic Therapy

1984 • 208 citations

Allocation of patients to treatment groups in a controlled clinical study

1978 • 190 citations

EFFECT OF INTRAVENOUS APSAC ON MORTALITY AFTER ACUTE MYOCARDIAL INFARCTION: PRELIMINARY REPORT OF A PLACEBO-CONTROLLED CLINICAL TRIAL

1988 • 167 citations

Clinical trial methodology

1978 • 106 citations

Cumulative antiplatelet effect of low‐dose enteric coated aspirin

1985 • 100 citations

Randomized factorial trial of high-dose intravenous streptokinase, of oral aspirin and of intravenous heparin in acute myocardial infarction

1987 • 82 citations

Anaphylactic Reactivity to Streptokinase

1984 • 60 citations

A randomized controlled trial of aspirin in the prevention of early mortality in myocardial infarction.

1979 • 50 citations

Potential time saving with pre-hospital intervention in acute myocardial infarction

1988 • 31 citations