Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

1995 • 15,623 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Automated MAD and MIR structure solution

1999 • 3,079 citations

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

1997 • 2,784 citations

Over-production of Proteins inEscherichia coli: Mutant Hosts that Allow Synthesis of some Membrane Proteins and Globular Proteins at High Levels

1996 • 1,892 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

1997 • 1,463 citations

Oncogenic Transcription Factors in the Human Acute Leukemias

1997 • 1,227 citations

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1999 • 1,091 citations

Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure.

1990 • 1,013 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

The Immunoglobulin Fold

1994 • 679 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

1997 • 574 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Molecular Cloning and Characterization of PEBP2β, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2α

1993 • 504 citations

Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias

1999 • 408 citations

Translocations, master genes, and differences between the origins of acute and chronic leukemias

1991 • 286 citations

Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1

1998 • 218 citations

Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer

1990 • 218 citations

CBFA1 Mutation Analysis and Functional Correlation with Phenotypic Variability in Cleidocranial Dysplasia

1999 • 215 citations

Mutation Analysis of Core Binding Factor A1 in Patients with Cleidocranial Dysplasia

1999 • 212 citations

Oncogenic conversion of transcription factors by chromosomal translocations

1991 • 209 citations

Molecular basis of tissue‐specific gene expression mediated by the Runt domain transcription factor PEBP2/CBF

1999 • 180 citations

The Missing Bone

1997 • 149 citations

Redox Regulation of the DNA Binding Activity in Transcription Factor PEBP2

1997 • 143 citations

Functional domains of the t(8;21) fusion protein, AML-1/ETO.

1995 • 113 citations

Sequence specificity of the core-binding factor

1993 • 108 citations

Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3.

1988 • 108 citations

[31] Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement

1997 • 102 citations

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.

1999 • 100 citations

Functional Dissection of the α and β Subunits of Transcription Factor PEBP2 and the Redox Susceptibility of Its DNA Binding Activity

1996 • 97 citations

Drosophila Homologs of the Proto-Oncogene Product PEBP2/CBFβ Regulate the DNA-Binding Properties of Runt

1996 • 91 citations

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

1997 • 82 citations

The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

1999 • 82 citations

Solution structure of core binding factor beta and map of the CBF alpha binding site.

1999 • 72 citations

Biochemical and Biophysical Properties of the Core-binding Factor α2 (AML1) DNA-binding Domain

1996 • 62 citations

Differential Protein Binding in Lymphocytes to a Sequence in the Enhancer of the Mouse Retrovirus SL3-3

1988 • 60 citations

Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye

1999 • 45 citations

Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta.

1999 • 42 citations

A simple screening for mutant DNA binding proteins: application to murine transcription factor PEBP2α subunit, a founding member of the Runt domain protein family

1997 • 29 citations

Redox Regulation of DNA-Binding Activity in Transcription Factor PEBP2: The Roles of Two Conserved Cysteine Residues

1999 • 5 citations