Optimization of Cell Surface Binding Enhances Efficiency and Specificity of Molecular Conjugate Gene Delivery

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

1995 • 6,103 citations

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

1993 • 1,186 citations

Adv. Drug Delivery Rev.

1997 • 881 citations

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

1987 • 841 citations

Evidence for the role of proteoglycans in cation-mediated gene transfer.

1996 • 765 citations

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

1994 • 668 citations

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

1990 • 657 citations

Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery

1996 • 583 citations

Design, Synthesis, and Characterization of a Cationic Peptide That Binds to Nucleic Acids and Permeabilizes Bilayers

1997 • 438 citations

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

1991 • 431 citations

Targeted gene delivery by tropism-modified adenoviral vectors

1996 • 431 citations

Folate-targeted, Anionic Liposome-entrapped Polylysine-condensed DNA for Tumor Cell-specific Gene Transfer

1996 • 398 citations

Characterization of Vectors for Gene Therapy Formed by Self-Assembly of DNA with Synthetic Block Co-Polymers

1996 • 365 citations

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.

1984 • 357 citations

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

1992 • 317 citations

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.

1994 • 306 citations

Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis

1994 • 278 citations

Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol) s conjugated at their distal terminals to monoclonal antibodies

1995 • 262 citations

Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses.

1995 • 244 citations

Intracellular Trafficking of Epidermal Growth Factor Family Ligands Is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction

1995 • 241 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis

1994 • 234 citations

Cell-specific targeting of Sindbis virus vectors displaying IgG-binding domains of protein A

1997 • 154 citations

Targeting DNA to Cells with Basic Fibroblast Growth Factor (FGF2)

1996 • 153 citations

The ‘adenobody’ approach to viral targeting: specific and enhanced adenoviral gene delivery

1997 • 152 citations

Gene delivery and expression mediated by an integrin-binding peptide.

1995 • 143 citations

Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers

1994 • 143 citations

Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor.

1980 • 134 citations

Localization of epidermal growth factor receptor in hepatocyte nuclei

1991 • 122 citations

In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer

1997 • 110 citations

Overexpression of Human Methylmalonyl CoA Mutase in Mice afterIn VivoGene Transfer with Asialoglycoprotein/Polylysine/DNA Complexes

1994 • 104 citations

Targeted Gene Delivery with a Low Molecular Weight Glycopeptide Carrier

1995 • 86 citations

Improvement of retroviral retargeting by using amino acid spacers between an additional binding domain and the N terminus of Moloney murine leukemia virus SU

1996 • 82 citations

Dioleoylmelittin as a Novel Serum-Insensitive Reagent for Efficient Transfection of Mammalian Cells

1997 • 70 citations

Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta.

1995 • 69 citations

Retroviral Display of Antibody Fragments; Interdomain Spacing Strongly Influences Vector Infectivity

1996 • 60 citations

Biotin Reagents for Antibody Pretargeting. 2. Synthesis and in Vitro Evaluation of Biotin Dimers and Trimers for Cross-Linking of Streptavidin

1997 • 36 citations

Nucleocytoplasmic transport is enhanced concomitant with nuclear accumulation of epidermal growth factor (EGF) binding activity in both 3T3-1 and EGF receptor reconstituted NR-6 fibroblasts.

1990 • 30 citations

Epidermal growth factor binding and trafficking dynamics in fibroblasts: relationship to cell proliferation

1990 • 15 citations

Ligand-Induced Translocation of Epidermal Growth Factor Receptor to the Nucleus of NR6/HER Fibroblasts Is Serum Dependent

1995 • 13 citations

Use of the Green Fluorescent Protein as a Quantitative Reporter of Epidermal Growth Factor Receptor-Mediated Gene Delivery

1997 • 8 citations