Pressure-dependent myogenic constriction of cerebral arteries occurs independently of voltage-dependent activation

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

On the local reactions of the arterial wall to changes of internal pressure

1902 • 1,485 citations

Relaxation of Arterial Smooth Muscle by Calcium Sparks

1995 • 1,383 citations

Signaling Mechanisms Underlying the Vascular Myogenic Response

1999 • 972 citations

Regulation of Arterial Tone by Activation of Calcium-Dependent Potassium Channels

1992 • 932 citations

Regulation of arterial diameter and wall [Ca²⁺] in cerebral arteries of rat by membrane potential and intravascular pressure

1998 • 638 citations

Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries

2002 • 487 citations

Autoregulation of blood flow.

1986 • 396 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β

2000 • 273 citations

Electro- and pharmacomechanical coupling in the smooth muscle cells of the rabbit ear artery.

1977 • 261 citations

The myogenic response: established facts and attractive hypotheses

1999 • 244 citations

Translocation of rhoA Associated with Ca2+ Sensitization of Smooth Muscle

1997 • 218 citations

Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels

1994 • 217 citations

Mechanotransduction of Rat Aortic Vascular Smooth Muscle Cells Requires RhoA and Intact Actin Filaments

1999 • 203 citations

Chloride channel blockers inhibit myogenic tone in rat cerebral arteries

1997 • 190 citations

20-Hydroxyeicosatetraenoic Acid-induced Vasoconstriction and Inhibition of Potassium Current in Cerebral Vascular Smooth Muscle Is Dependent on Activation of Protein Kinase C

1997 • 182 citations

Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20‐HETE which enhances L‐type Ca²⁺ current

1998 • 182 citations

Calcium measurement in isolated arterioles during myogenic and agonist stimulation

1991 • 178 citations

Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation.

1991 • 177 citations

Pressure and flow‐dependent vascular tone

1991 • 176 citations

Excitation—contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery

1977 • 173 citations

Vascular muscle cell depolarization and activation in renal arteries on elevation of transmural pressure

1987 • 142 citations

Evidence for protein kinase C involvement in arteriolar myogenic reactivity

1990 • 118 citations

Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries

1993 • 117 citations

Myogenic contraction by modulation of voltage‐dependent calcium currents in isolated rat cerebral arteries.

1997 • 97 citations

Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol

1994 • 96 citations

Sequestration of a G-protein βγ Subunit or ADP-ribosylation of Rho Can Inhibit Thrombin-induced Activation of Platelet Phosphoinositide 3-Kinases

1995 • 93 citations

Myogenic Activation and Calcium Sensitivity of Cannulated Rat Mesenteric Small Arteries

1998 • 93 citations

Vascular Smooth Muscle Actin Cytoskeleton in Cerebral Artery Forced Dilatation

1998 • 91 citations

Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C

1999 • 85 citations

Voltage-Operated Calcium Channels Are Essential for the Myogenic Responsiveness of Cannulated Rat Mesenteric Small Arteries

1996 • 84 citations

Non‐specificity of chloride channel blockers in rat cerebral arteries: block of the L‐type calcium channel

1998 • 84 citations

Role of protein kinase C- or RhoA-induced Ca2+ sensitization in stretch-induced myogenic tone

2002 • 74 citations

Involvement of Rho-Kinase and the Actin Filament Network in Angiotensin II–Induced Contraction and Extracellular Signal–Regulated Kinase Activity in Intact Rat Mesenteric Resistance Arteries

2001 • 71 citations

Estrogen regulates myogenic tone in pressurized cerebral arteries by enhanced basal release of nitric oxide

1997 • 70 citations

Heterogeneity of endothelium-dependent vasodilation in pressurized cerebral and small mesenteric resistance arteries of the rat.

1999 • 69 citations

Involvement of protein kinase C, tyrosine kinases, and Rho kinase in Ca²⁺handling of human small arteries

2000 • 61 citations

Calcium and mechanotransduction of the myogenic response

1997 • 60 citations

Increased Ca²⁺sensitivity as a key mechanism of PKC-induced constriction in pressurized cerebral arteries

1999 • 59 citations

Temporal Aspects of Ca<sup>2+</sup> and Myosin Phosphorylation during Myogenic and Norepinephrine-Induced Arteriolar Constriction

2000 • 56 citations

Local Ca ²⁺ Entry Through L-Type Ca ²⁺ Channels Activates Ca ²⁺ -Dependent K ⁺ Channels in Rabbit Coronary Myocytes

1999 • 53 citations

Role of cytosolic Ca2+ and protein kinase C in developing myogenic contraction in isolated rat small arteries

1997 • 50 citations

Modification of myogenic intrinsic tone and [Ca2+]i of rat isolated arterioles by ryanodine and cyclopiazonic acid.

1993 • 44 citations

Signal transduction in spontaneous myogenic tone in isolated arterioles from rat skeletal muscle

1999 • 41 citations

Stretch Induces Mitogen-Activated Protein Kinase Activation and Myogenic Tone Through 2 Distinct Pathways

1999 • 41 citations

Transduction of physical force by the vascular wall

1995 • 39 citations

Staurosporine, a protein kinase C inhibitor, attenuates Ca2+-dependent stretch-induced vascular tone

1989 • 37 citations

Mechanisms of intrinsic tone in ferret vascular smooth muscle.

1992 • 30 citations

Temperature and protein kinase C modulate myofilament Ca²⁺sensitivity in pressurized rat cerebral arteries

1998 • 29 citations

Phorbol Ester-induced Potentiation of Myogenic Tone is not Associated with Increases in Ca2+ Influx, Myoplasmic Free Ca2+ Concentration, or 20-kDa Myosin Light Chain Phosphorylation

1994 • 26 citations

Effects of staurosporine and calphostin C, two structurally unrelated inhibitors of protein kinase C, on vascular tone

1993 • 18 citations

Elevated glucose potentiates contraction of isolated rat resistance arteries and augments protein kinase C—induced intracellular calcium release

1999 • 13 citations