The Human Placental Lactogen Genes: Structure, Function, Evolution and Transcriptional Regulation

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

1988 • 525 citations

The human growth hormone locus: Nucleotide sequence, biology, and evolution

1989 • 475 citations

Sequences of Pituitary and Placental Lactogenic and Growth Hormones: Evolution from a Primordial Peptide by Gene Reduplication

1971 • 371 citations

Presence in the Human Placenta and Term Serum of a Highly Lactogenic Substance Immunologically Related to Pituitary Growth Hormone

1962 • 355 citations

Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus.

1987 • 306 citations

A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells

1987 • 301 citations

The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence

1988 • 301 citations

Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence

1989 • 243 citations

CHORIONIC GROWTH HORMONE‐PROLACTIN (CGP): SECRETION, DISPOSITION, BIOLOGIC ACTIVITY IN MAN, AND POSTULATED FUNCTION AS THE “GROWTH HORMONE” OF THE SECOND HALF OF PREGNANCY^*

1968 • 236 citations

Starvation in Human Pregnancy: Hypoglycemia, Hypoinsulinemia, and Hyperketonemia

1970 • 224 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

1987 • 218 citations

Human Placental Lactogen: Studies of Its Acute Metabolic Effects and Disposition in Normal Man*

1967 • 198 citations

Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat

1989 • 188 citations

The JAr cell line - continuous human multi-hormone production and controls

1971 • 175 citations

Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta.

1982 • 164 citations

The 20,000-dalton variant of human growth hormone: Location of the amino acid deletions

1980 • 163 citations

Localization of Anti-human Growth Hormone Serum within the Human Placenta : Evidence for a Human Chorionic ‘Growth Hormone-prolactin’

1963 • 152 citations

EXPRESSION OF THE GROWTH HORMONE VARIANT GENE IN HUMAN PLACENTA

1987 • 138 citations

Isolation and identification of a cDNA clone of rat placental lactogen II.

1986 • 128 citations

One cell-specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.

1987 • 127 citations

Sp1 activates transcription without enhancing DNA-binding activity of the TATA box factor.

1989 • 123 citations

Purification of Growth Hormone-Specific Transcription Factor GHF-1 Containing Homeobox

1989 • 121 citations

Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins.

1988 • 114 citations

Purification of a Placental Factor with Immunological and Chemical Similarity to Human Growth Hormone11

1965 • 114 citations

Interrelationships of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific β1-glycoprotein throughout normal human gestation

1980 • 110 citations

Two structurally different genes produce the same secreted human placental lactogen hormone.

1983 • 107 citations

Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences andtrans-activate the human growth hormone gene

1990 • 102 citations

CLONAL LINES OF HUMAN CHORIOCARCINOMA CELLS IN CULTURE

1971 • 101 citations

Serum Chorionic “Growth Hormone-Prolactin” and Serum Pituitary Growth Hormone in Mother and Fetus at Term

1965 • 93 citations

Relative Effects of Pregnancy, Human Placental Lactogen and Prednisolone on Carbohydrate Tolerance in Normal and Subclinical Diabetic Subjects

1969 • 89 citations

Nucleotide sequence of part of the gene for human chorionic somatomammotropin: Purification of DNA complementary to predominant mRNA species

1977 • 88 citations

A promoter of the rat insulin-like growth factor II gene consists of minimal control elements

1988 • 88 citations

Metabolic Effects of Placental Lactogen (HPL) in Man

1968 • 87 citations

Placental Lactogen and Growth Hormone Receptors in Human Fetal Tissues: Relationship to Fetal Plasma Human Placental Lactogen Concentrations and Fetal Growth*

1988 • 84 citations

Dynamics of human placental lactogen

1966 • 82 citations

The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells.

1986 • 82 citations

Metabolic Clearance Rate and Production Rate of Chorionic Growth Hormone-Prolactin in Late Pregnancy

1968 • 82 citations

ADIPOSE TISSUE METABOLISM IN PREGNANCY: THE LIPOLYTIC EFFECT OF HUMAN PLACENTAL LACTOGEN

1978 • 82 citations

Regulation of Amino Acid Uptake and Deoxyribonucleic Acid Synthesis in Isolated Human Fetal Fibroblasts and Myoblasts: Effect of Human Placental Lactogen, Somatomedin-C, Multiplication-Stimulating Activity, and Insulin*

1986 • 79 citations

Identification of Placental Human Growth Hormone as the Growth Hormone-V Gene Expression Product*

1990 • 78 citations

Heterogeneity of Human Growth Hormone

1974 • 77 citations

Human placental lactogen (HPL), a trophoblastic hormone synergizing with chorionic gonadotropin and potentiating the anabolic effects of pituitary growth hormone

1964 • 74 citations

Human placental lactogen transcriptional enhancer. Tissue specificity and binding with specific proteins.

1990 • 74 citations

Human placental lactogen (HPL) and placental weight

1968 • 73 citations

Incorporation of [³H]thymidine by isolated fetal myoblasts and fibroblasts in response to human placental lactogen (HPL): Possible mediation of HPL action by release of immunoreactive SM‐C

1985 • 71 citations

PLASMA CHORIONIC SOMATOMAMMOTROPIN LEVELS DURING STARVATION IN MID-PREGNANCY¹

1971 • 70 citations

Pituitary-Specific Factor Binding to the Human Prolactin, Growth Hormone, and Placental Lactogen Genes

1989 • 65 citations

CONCENTRATION OF CHORIONIC GONADOTROPHIN AND CHORIONIC SOMATOMAMMOTROPHIN IN MATERNAL SERUM, AMNIOTIC FLUID AND CORD BLOOD SERUM AT TERM

1972 • 62 citations

The human growth hormone gene contains both positive and negative control elements.

1988 • 60 citations

Transcription factor Sp1 binds to and activates a human hsp70 gene promoter.

1989 • 58 citations

Regulated expression of chimaeric genes containing the 5′-flanking regions of human growth hormone-related genes in transiently transfected rat anterior pituitary tumor cells

1987 • 55 citations

Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster

1986 • 53 citations

Thyroid hormone receptors bind to defined regions of the growth hormone and placental lactogen genes.

1986 • 51 citations

Tissue-Specific Expression and Thyroid Hormone Regulation of the Endogenous Placental Growth Hormone Variant and Chorionic Somatomammotropin Genes in a Human Choriocarcinoma Cell Line*

1991 • 47 citations

The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro.

1990 • 44 citations

An Effect of Gene Dosage on Production of Human Chorionic Somatomammotropin*

1985 • 44 citations

Purification of the Insulin-like growth factor II (IGF-II) receptor from an IGF-II-producing cell line, and generation of an antibody which both immunoprecipitates and blocks the type 2 IGF receptor

1986 • 40 citations

DNA Sequences Involved in the Transcriptional Activation of a Human Placental Lactogen Gene

1990 • 39 citations

Relationship of maternal and fetal levels of human placental lactogen to the weight and sex of the fetus

1984 • 39 citations

Transcriptional products of the human placental lactogen gene.

1982 • 36 citations

Transplantation of Insulin-Like Growth Factor-II-Secreting Tumors into Nude Rodents*

1987 • 31 citations

Stimulation of DNA Synthesis by Human Placental Lactogen or Insulin in Organ Cultures of Benign Human Breast Tumors

1977 • 30 citations

HUMAN CHORIONIC SOMATO-MAMMOTROPHIN IN SERUM AND URINE IN VARIOUS STAGES OF PREGNANCY: ITS CORRELATION WITH ENZYMES AND OESTROGENS

1972 • 28 citations

Multiple origins of transcription for the human placental lactogen genes.

1984 • 28 citations

Successful transplantation of human benign breast tumors into the athymic nude mouse and demonstration of enhanced DNA synthesis by human placental lactogen.

1978 • 24 citations

Growth Regulation of Cultured Human Pituitary Cells by Steroidal and Nonsteroidal Compounds in Defined Medium

1979 • 23 citations

Characterisation of antisera to a growth‐hormone‐like placental antigen (human placental lactogen): Immunofluorescence studies with these sera on normal and pathological syncytiotrophoblast

1969 • 23 citations

The Double Effect of Human Chorionic Somatomammotropin (HCS) and Pregnancy on Lipogenesis and on Lipolysis in the Isolated Rat Epididymal Fat Pad and Fat Pad Cells

2009 • 22 citations

Time of Appearance of Human Placental Lactogen in the Embryo

1970 • 20 citations

Coding potential of transfected human placental lactogen genes

1990 • 20 citations

Studies on the Metabolism of Human Placental Lactogen in Pregnancy

1970 • 16 citations

Transcriptional enhancers play a major role in gene expression

1986 • 11 citations

Plasma human chorionic somatomammotropin deficiency in a normal pregnancy is the consequence of low concentration of messenger RNA coding for human chorionic somatomammotropin

1983 • 10 citations

COMPARATIVE STUDIES ON THE METABOLIC EFFECTS OF SOME PARAMETERS OF CARBOHYDRATE AND LIPID METABOLISM AFTER INTRAVENOUS ADMINISTRATION OF HUMAN PLACENTAL LACTOGEN, HUMAN PROLACTIN AND GROWTH HORMONE

1973 • 9 citations

SIMILARITIES IN THE STRUCTURE AND FUNCTION OF BOTH THE MATURE FORMS AND BIOSYNTHETIC PRECURSORS OF PLACENTAL LACTOGEN AND GROWTH HORMONE*

1980 • 5 citations