Chlamydia trachomatis: impact on human reproduction

Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis

1998 • 1,548 citations

Incidence, prevalence, and trends of acute pelvic inflammatory disease and its consequences in industrialized countries

1980 • 741 citations

Factors that affect outcome of in-vitro fertilisation treatment

1996 • 698 citations

Genital chlamydial infections: Epidemiology and reproductive sequelae

1991 • 564 citations

Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis

1994 • 549 citations

Independent Associations of Bacterial Vaginosis and Chlamydia trachomatis Infection With Adverse Pregnancy Outcome

1986 • 537 citations

Current methods of laboratory diagnosis of Chlamydia trachomatis infections

1997 • 518 citations

1998 Guidelines for Treatment of Sexually Transmitted Diseases

1997 • 486 citations

Causes of the Acute Urethral Syndrome in Women

1980 • 484 citations

Chlamydial Infections

1978 • 479 citations

Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro.

1993 • 471 citations

Sperm antibodies: their role in infertility

1984 • 456 citations

Respiratory-Tract Colonization and a Distinctive Pneumonia Syndrome in Infants Infected withChlamydia trachomatis

1977 • 446 citations

Etiology of Nongonococcal Urethritis

1975 • 440 citations

Chlamydia trachomatisInfection in Patients with Acute Salpingitis

1977 • 417 citations

Global epidemiology of sexually transmitted diseases

1998 • 404 citations

The biologic significance of white blood cells in semen

1995 • 399 citations

Recurrent chlamydial infections increase the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease

1997 • 302 citations

Prematurity and Perinatal Mortality in Pregnancies Complicated by Maternal Chlamydia trachomatis Infections

1982 • 300 citations

Incidence, trends, and risks of ectopic pregnancy in a population of women.

1981 • 288 citations

A Simple and Sensitive Micro‐Method for Demonstration of Sperm‐Agglutinating Activity in Serum from Infertile Men and Women

1974 • 287 citations

Delayed care of pelvic inflammatory disease as a risk factor for impaired fertility

1993 • 275 citations

Chlamydia trachomatisas a Cause of Acute “Idiopathic” Epididymitis

1978 • 260 citations

Diagnosis of Chlamydia trachomatis infections in men and women by testing first-void urine by ligase chain reaction

1994 • 238 citations

A simple method of screening for antisperm antibodies in the human male. Detection of spermatozoal surface IgG with the direct mixed antiglobulin reaction carried out on untreated fresh human semen.

1978 • 223 citations

Chlamydial disease pathogenesis. Ocular hypersensitivity elicited by a genus-specific 57-kD protein.

1989 • 221 citations

The Cost of a Successful Delivery with in Vitro Fertilization

1994 • 218 citations

Chlamydial Serology in Infertile women by Immunofluorescence

1979 • 217 citations

Screening for chlamydial infections and the risk of ectopic pregnancy in a county in Sweden: ecological analysis

1998 • 212 citations

Diagnosis of Accessory Gland Infection and its Possible Role in Male Infertility

1980 • 195 citations

Prospective study of leukocytes and leukocyte subpopulations in semen suggests they are not a cause of male infertility

1993 • 195 citations

The prediction of the chance to conceive in subfertile couples

1994 • 186 citations

The accuracy of serum chlamydial antibodies in the diagnosis of tubal pathology: a meta-analysis

1997 • 176 citations

Pelvic Inflammatory Disease

1994 • 166 citations

Prevalence and manifestations of endometritis among women with cervicitis

1985 • 139 citations

The role of antisperm antibodies in infertility

1994 • 139 citations

Azithromycin for Empirical Treatment of the Nongonococcal Urethritis Syndrome in Men

1995 • 138 citations

Relationship between genital tract infections, sperm antibodies in seminal fluid, and infertility

1983 • 132 citations

Sexually transmitted diseases and infertility.

1994 • 129 citations

Histopathology of endocervical infection caused by Chlamydia trachomatis, herpes simplex virus, Trichomonas vaginalis, and Neisseria gonorrhoeae

1990 • 129 citations

Chlamydial serology in 1303 asymptomatic subfertile couples

1997 • 126 citations

Cytologic manifestations of cervical and vaginal infections. I. Epithelial and inflammatory cellular changes

1985 • 118 citations

Persistence of chlamydial antibodies after pelvic inflammatory disease

1986 • 113 citations

In vitro tests of the adherence of Chlamydia trachomatis to human spermatozoa

1984 • 112 citations

Prevalence and Correlates of Antibody to Chlamydial Heat Shock Protein in Women Attending Sexually Transmitted Disease Clinics and Women with Confirmed Pelvic Inflammatory Disease

1997 • 106 citations

A comparison of the fallopian tube's response to overt and silent salpingitis.

1989 • 105 citations

Morbidity following pelvic inflammatory disease

1993 • 103 citations

Demonstration of Delayed Hypersensitivity in Chlamydia trachomatis Salpingitis in Monkeys: A Pathogenic Mechanism of Tubal Damage

1994 • 102 citations

Comparison of Performances of Two Commercially Available Tests, a PCR Assay and a Ligase Chain Reaction Test, in Detection of Urogenital Chlamydia trachomatis Infection

1998 • 97 citations

Cost-benefit analysis of first-void urine chlamydia trachomatis screening program

1998 • 95 citations

Detection of Chlamydia trachomatis infection in urine samples from men and women by ligase chain reaction

1995 • 94 citations

Immunoglobulin Class of Antispermatozoal Antibodies from Infertile Men and Inhibition of in vitro Sperm Penetration into Cervical Mucus

1980 • 93 citations

Male genital mycoplasmas and Chlamydia trachomatis culture: its relationship with accessory gland function, sperm quality, and autoimmunity

1990 • 93 citations

Antibodies to Chlamydia trachomatis in sera of women with recurrent spontaneous abortions

1992 • 92 citations

Relationship between an asymptomatic male genital tract exposure to Chlamydia trachomatis and an autoimmune response to spermatozoa

1995 • 88 citations

Mucopurulent Cervicitis—the Ignored Counterpart in Women of Urethritis in Men

1985 • 87 citations

Antibiotic therapy and leukocytospermia: a prospective, randomized, controlled study

1995 • 87 citations

Antibodies to Chlamydia Species in Patients Attending a Genitourinary Clinic and the Impact of Antibodies to C. pneumoniae and C. psittaci on the Sensitivity and the Specificity of C. trachomatis Serology Tests

1993 • 87 citations

Prognostic value of in vitro sperm penetration into hormonally standardized human cervical mucus

1989 • 85 citations

In-vitro fertilization outcome in women with hydrosalpinx

1996 • 85 citations

Programmes to reduce pelvic inflammatory disease—the Swedish experience

1998 • 82 citations

Humoral Immune Response to Conserved Epitopes ofChlamydia trachomatisand Human 60‐kDa Heat‐Shock Protein in Women with Pelvic Inflammatory Disease

1998 • 82 citations

The Role of Chlamydiae in Genitourinary Disease

1981 • 80 citations

Chlamydial pelvic inflammatory disease

1996 • 79 citations

Immunology: Antibodies to Chlamydia trachomatis in semen and relationship with parameters of male fertility

1996 • 77 citations

Prognostic value of the postcoital test: prospective study based on time‐specific conception rates

1982 • 76 citations

Chlamydia trachomatis induces an inflammatory response in the male genital tract and is associated with altered semen quality

1991 • 76 citations

Differentiation of round cells in semen by means of monoclonal antibodies and relationship with male fertility

1992 • 73 citations

Chlamydial infection—a female and/or male infertility factor?

1990 • 73 citations

Carbohydrate moieties on sperm surface: physiological relevance

1995 • 70 citations

Immunology: Autoimmunity to spermatozoa, asymptomatic Chlamydia trachomatis genital tract infection and γδ T lymphocytes in seminal fluid from the male partners of couples with unexplained infertility

1995 • 64 citations

Relationship between local anti-sperm antibodies and sperm–mucus interaction in vitro and in vivo*

1991 • 63 citations

Circulating antisperm antibodies and fertility prognosis: a prospective study*

1989 • 63 citations

Evaluation of urine-based screening strategies to detect Chlamydia trachomatis among sexually active asymptomatic young males.

1993 • 63 citations

Anaerobes in ejaculates of subfertile men

1995 • 61 citations

Inhibitory effect on the formation of chlamydial inclusions in McCoy cells by seminal fluid and some of its components.

1980 • 61 citations

Prevention of Pelvic Inflammatory Disease by Screening for Cervical Chlamydial Infection

1997 • 59 citations

Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60 kDa heat shock protein (hsp60) in infertile couples and its relationship to antibodies to C.trachomatis surface antigens and the Escherichia coli and human HSP60

1998 • 59 citations

Chlamydia trachomatis: a major threat to reproduction

1989 • 58 citations

Evaluation of granulocyte elastase as a seminal plasma marker for leukocytospermia

1988 • 56 citations

Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein

1998 • 56 citations

Reproducibility problems with the AMPLICOR PCR Chlamydia trachomatis test

1997 • 55 citations

A Review of the Microbiology, Immunology, and Clinical Implications of Chlamydia trachomatis Infections

1992 • 55 citations

Azithromycin and erythromycin in the treatment of cervical chlamydial infection during pregnancy.

1994 • 54 citations

Reducing the Risk of Multiple Births by Transfer of Two Embryos After In Vitro Fertilization

1999 • 54 citations

Comparison of the ligase chain reaction with cell culture for the diagnosis of Chlamydia trachomatis infection in women.

1996 • 53 citations

Comparison of different methods for the investigation of antisperm antibodies on spermatozoa, in seminal plasma and in serum

1995 • 52 citations

Randomized treatment of mucopurulent cervicitis with doxycycline or amoxicillin

1989 • 52 citations

Chlamydial antibodies in semen: Search for “silent” chlamydial infections in asymptomatic andrological patients

1996 • 51 citations

Experimental epididymitis due to Chlamydia trachomatis in rats

1992 • 51 citations

Immunology: The 60 kDa heat shock protein in human semen: relationship with antibodies to spermatozoa and Chlamydia trachomatis

1996 • 50 citations

Clinical relevance of sperm morphology assessment using strict criteria and relationship with sperm-mucus interaction in vivo and in vitro

1995 • 50 citations

Immunology: Chlamydial immunoglobulin IgG and IgA antibodies in serum and semen are not associated with the presence of Chlamydia trachomatis DNA or rRNA in semen from male partners of infertile couples

1995 • 49 citations

Experimental Epididymitis and Urethritis in Grivet Monkeys Provoked by Chlamydia Trachomatis

1980 • 48 citations

Microbiology of semen specimens from males attending a fertility clinic

1997 • 48 citations

Immunology of spermatozoa and cervical mucus*

1988 • 48 citations

The relationship of infection with Chlamydia trachomatis to the parameters of male fertility and sperm autoimmunity

1987 • 48 citations

Chlamydia trachomatis Seropositivity During Pregnancy Is Associated with Perinatal Complications

1995 • 47 citations

Chlamydia trachomatis attached to spermatozoa recovered from the peritoneal cavity of patients with salpingitis.

1987 • 46 citations

Colposcopic Manifestations of Cervical and Vaginal Infections

1988 • 46 citations

Changes in the Testis Parenchyma Caused by Acute Nonspecific Epididymitis

1968 • 45 citations

Antisperm antibodies in cervical mucus in an unselected subfertile population*

1993 • 45 citations

Lack of association between serum antibodies to Chlamydia trachomatis and a history of recurrent pregnancy loss

1999 • 45 citations

Chlamydia trachomatis in non-specific urethritis.

1978 • 44 citations

A Prospective Study of Antisperm Antibody Development in Acute Epididymitis

1986 • 42 citations

Is there a role for Chlamydia trachomatis and genital mycoplasma in male infertility?

1987 • 42 citations

Sperm Penetration of Cervical Mucus as a Criterion of Male Fertility

1972 • 41 citations

Chlamydia trachomatisconjunctivitis: Prevalence and association with genital tract infection

1995 • 40 citations

Detection of Chlamydia trachomatis in semen by antibody-enzyme immunoassay compared with polymerase chain reaction, antigenenzyme immunoassay, and urethral cell culture

1994 • 39 citations

Does serologic evidence of remote Chlamydia trachomatis infection and its heat shock protein (CHSP 60) affect in vitro fertilization-embryo transfer outcome?

1996 • 37 citations

Detection of Chlamydia trachomatis in semen of artificial insemination donors by the polymerase chain reaction

1993 • 37 citations

Chlamydial Infection and Male Infertility: An Epidemiological Study

1989 • 34 citations

The role of chlamydial antibodies in an in vitro fertilization program

1987 • 33 citations

Chlamydial serology in the investigation of infertility

1992 • 32 citations

Electron Microscopy ofChlamydia trachomatisInfection of the Male Genital Tract

1991 • 31 citations

Manifestations of Chlamydia induced arthritis in patients with silent versus symptomatic urogenital chlamydial infection.

1995 • 31 citations

Sperm-cervical mucus interaction, in particular in the presence of antispermatozoal antibodies

1988 • 31 citations

Diagnosis of urogenital Chlamydia trachomatis infection by use of DNA amplification

1999 • 31 citations

Chronic prostatitis, chlamydia trachomatis and infertility

1983 • 31 citations

Antisperm antibodies and lymphocyte subsets in semen—not a simple relationship

1990 • 29 citations

Transmission of Chlamydia trachomatis by artificial insemination

1986 • 28 citations

Complement C3, coeruloplasmin and PMN-elastase in the ejaculate in chronic prostato-adnexitis and their diagnostic value

1991 • 28 citations

The Relevance of Chlamydia trachomatis in Acute Epididymitis in Young Men

1988 • 28 citations

Characterization of ciliary activity in distal Fallopian tube biopsies of women with obstructive tubal infertility

1998 • 28 citations

Antisperm antibodies and microorganisms in genital secretions-a clinically significant relationship?

2009 • 28 citations

Immunology: Determination of antisperm antibodies in serum samples by means of enzyme-linked immunosorbent assay—a procedure to be recommended during infertility investigation?*

1993 • 27 citations

Second laparoscopy after treatment of acute pelvic inflammatory disease.

1987 • 26 citations

The Role of Chlamyudia trachomatis in Epididymitis

1987 • 25 citations

Induction of immunoresponse by subclinical male genital tract infection?

1996 • 25 citations

Detection and treatment of antispermatozoal antibodies in men

1989 • 25 citations

Immune Pathogenesis of Asymptomatic Chlamydia trachomatis Infections in the Female Genital Tract

1995 • 24 citations

Male Fertility and Positive Chlamydial Serology A Study of 61 Fertile and 82 Subfertile Men

1987 • 24 citations

Does previous Chlamydia trachomatis infection influence the pregnancy rate of in vitro fertilization and embryo replacement?

1990 • 21 citations

Is serology of any use when searching for correlations between Chlamydia trachomatis infection and male infertility?

1990 • 21 citations

Rapid Decrease of Endemic Gonorrhea in Finland

1998 • 21 citations

Cryosurvival of Chlamydia trachomatis during cryopreservation of human spermatozoa

1985 • 20 citations

The role of chlamydial serology in fertile and subfertile men

1989 • 20 citations

Antibody Response to B Cell Epitopes of Chlamydia trachomatis 60-kDa Heat-Shock Protein and Corresponding Mycobacterial and Human Peptides in Infants with Chlamydia) Pneumonitis

1994 • 18 citations

Immunological aspects of subfertility.

1995 • 17 citations

[The role of Chlamydia trachomatis in producing abnormal movements by spermatozoa].

1989 • 17 citations

A Proposed Mouse Model for Acute Epididymitis Provoked by Genital Serovar E, Chlamydia trachomatis1

1989 • 13 citations

Molecular approaches to the diagnosis of malse infertility

1996 • 11 citations

Chlamydia trachomatis--clinical significance and strategies of intervention.

1990 • 9 citations

The sperm penetration test (P-test) can predict fecundability in the male partner from infertile couples

2009 • 8 citations

Bedeutung von Chlamydia trachomatis für die weibliche Fertilität unter besonderer Berücksichtigung der Prävalenz im Endometrium

1988 • 7 citations

Artificial Insemination with Donor Semen: The Necessity of Frequent Donor Screening

1990 • 6 citations

A possible role of Chlamydia trachomatis as a causative agent in epidydimal infertility.

1985 • 4 citations

Chlamydia trachomatis and cervical cancer

1998 • 3 citations