Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles.

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

1983 • 1,548 citations

International Union of Pharmacology. XIII. Classification of histamine receptors.

1997 • 869 citations

Cloning and Functional Expression of the Human Histamine H₃Receptor

1999 • 710 citations

pA_x AND COMPETITIVE DRUG ANTAGONISM

1949 • 247 citations

25 Years since the discovery of presynaptic receptors: present knowledge and future perspectives

1997 • 164 citations

Identification of two H3-histamine receptor subtypes.

1990 • 146 citations

[125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors.

1994 • 130 citations

Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor

1999 • 118 citations

Functional Relationship between Mast Cells and C-Sensitive Nerve Fibres Evidenced by Histamine H3-Receptor Modulation in Rat Lung and Spleen

1994 • 102 citations

Functional Identification of Histamine H ₃ -Receptors in the Human Heart

1995 • 90 citations

Purification of a histamine H3 receptor negatively coupled to phosphoinositide turnover in the human gastric cell line HGT1.

1992 • 65 citations

Molecular and genetic basis of β2 -adrenergic receptor function☆☆☆

1999 • 64 citations

Structure and function of G protein coupled receptors

1991 • 64 citations

Structural characterization and binding sites of G-protein-coupled receptors

1996 • 62 citations

[¹²⁵I]Iodoproxyfan and Related Compounds: A Reversible Radioligand and Novel Classes of Antagonists with High Affinity and Selectivity for the Histamine H₃ Receptor

1996 • 59 citations

Intermediate affinity and potency of clozapine and low affinity of other neuroleptics and of antidepressants at H3 receptors

1994 • 47 citations

Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum: evidence for H3 receptor heterogeneity?

1996 • 46 citations

Histamine H3‐receptor activation augments voltage‐dependent Ca2+ current via GTP hydrolysis in rabbit saphenous artery.

1992 • 46 citations

Identification of Residues in Transmembrane Regions III and VI that Contribute to the Ligand Binding Site of the Serotonin 5‐HT₆ Receptor

1998 • 42 citations

Interaction of clozapine with the histamine H₃ receptor in rat brain

1995 • 41 citations

Characterization of the histamine receptors in the guinea‐pig lung: evidence for relaxant histamine H₃ receptors in the trachea

1994 • 35 citations

Site‐directed mutagenesis of the human β₃‐adrenoceptor

1998 • 30 citations

The profiles of human and primate []N∝-methylhistamine binding differ from that of rodents

1999 • 30 citations

The Histamine H3 Receptor

2000 • 30 citations

Novel Partial Agonists for the Histamine H₃ Receptor with High in Vitro and in Vivo Activity

1999 • 27 citations

Evidence that histamine homologues discriminate between H₃‐receptors in guinea‐pig cerebral cortex and ileum longitudinal muscle myenteric plexus

1999 • 26 citations

Characterization of the binding of [³H]‐clobenpropit to histamine H₃‐receptors in guinea‐pig cerebral cortex membranes

1999 • 20 citations

Site-Directed Mutagenesis of α-Adrenergic Receptors

1994 • 4 citations