First characterization of inhibitor-resistant TEM (IRT) beta-lactamases in Klebsiella pneumoniae strains

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

1978 • 791 citations

Extended-spectrum plasmid-mediated -lactamases

1995 • 160 citations

Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli

1993 • 158 citations

Origin and impact of plasmid-mediated extended-spectrum beta-lactamases

1994 • 157 citations

Inactivation of class A .beta.-lactamases by clavulanic acid: the role of arginine-244 in a proposed nonconcerted sequence of events

1993 • 135 citations

An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase.

1989 • 134 citations

Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors

1994 • 123 citations

Nucleotide sequences of the genes coding for the TEM-like β-lactamases IRT-1 and IRT-2 (formerly called TRI-1 and TRI-2)

1994 • 122 citations

Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli

1995 • 120 citations

Clinical isolates of Escherichia coli producing TRI β-lactamases: novel TEM-enzymes conferring resistance to β-lactamase inhibitors

1992 • 119 citations

Factors determining resistance to β-lactam combined with β-lactamase inhibitors in Escherichia coli

1991 • 100 citations

Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.

1992 • 96 citations

Variations between the nucleotide sequences of Tn1, Tn2, and Tn3 and expression of beta-lactamase in Pseudomonas aeruginosa and Escherichia coli

1987 • 85 citations

Frequency of inhibitor-resistant TEM β-lactamases in Escherichia coli isolates from urinary tract infections in Fran

1994 • 72 citations

β‐lactamase TEM1 of E. coli Crystal structure determination at 2.5 Å resolution

1992 • 72 citations

Sequences of the genes blaT-1B and blaT-2

1991 • 69 citations

Nucleotide sequences of CAZ-2, CAZ-6, and CAZ-7 beta-lactamase genes

1992 • 66 citations

TRC-1: Emergence of a clavulanic acid-resistant TEM β-lactamase in a clinical strain

1992 • 58 citations

Small plasmids are involved in amoxicillin-clavulanate resistance in Escherichia coli

1989 • 53 citations

Clinical isolates of Escherichia coli producing multiple TEM mutants resistant to β-lactamase inhibitors

1994 • 48 citations

Characterization and amino acid sequence of IRT-4, a novel TEM-type enzyme with a decreased susceptibility to β-lactamase inhibitors

1994 • 36 citations

Does high level production of SHV-type penicillinase confer resistance to ceftazidime in enterobacteriaceae?

1992 • 32 citations