Induction of mutation of a synthetic c-Ha-ras gene containing hypoxanthine.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

DNA REPAIR ENZYMES

1988 • 822 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Human-tumor-derived cell lines contain common and different transforming genes

1981 • 455 citations

Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.

1987 • 399 citations

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

1990 • 395 citations

Base pairing involving deoxyinosine: implications for probe design

1985 • 330 citations

An alternative approach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions.

1985 • 305 citations

Purification of ras GTPase activating protein from bovine brain.

1988 • 255 citations

Nucleotide insertion kinetics opposite abasic lesions in DNA.

1987 • 209 citations

Hypoxanthine in deoxyribonucleic acid: generation by heat-induced hydrolysis of adenine residues and release in free form by a deoxyribonucleic acid glycosylase from calf thymus

1980 • 177 citations

Human cancer and cellular oncogenes

1987 • 159 citations

Studies on nucleic acid interactions I. Stabilities of mini-duplexes (dG₂A₄XA₄G₂.dC₂T₄YT₄C₂) and self-complementary d(GGGAAXYTTCCC) containing deoxyinosine and other mismatched bases

1986 • 100 citations

Synthesis and expression of a synthetic gene for the activated human c-Ha-ras protein.

1986 • 83 citations

Inosine.adenine base pairs in a B-DNA duplex

1987 • 68 citations

Preferential recognition of I·T base-pairs in the initiation of excision-repair by hypoxanthine-DNA glycosylase

1991 • 44 citations

Studies on the Nucleotide Arrangement in Deoxyribonucleic Acids. XI. Selective Removal of Cytosine as a Tool for the Study of the Nucleotide Arrangement in Deoxyribonucleic Acid^*

1966 • 39 citations

Identification of I:A mismatch base-pairing structure in DNA.

1987 • 38 citations

Transformation of NIH3T3 Cells with Synthetic c‐Ha‐ras Genes

1989 • 20 citations

Overproduction of cellular and activated Ha-ras proteins by mutating a synthetic gene.

1987 • 18 citations

Transforming Activity of a Synthetic c‐Ha‐ras Gene Containing O⁶‐Methylguanine in Codon 12

1991 • 12 citations

Synthesis and thermal stability of dodecadeoxyribonucleotides containing deoxyinosine pairing with four major bases.

1989 • 9 citations

Synthesis of wobble pairing oligoribonucleotides.

1989 • 5 citations

Synthesis and properties of hexanucleotides containing deoxyinosine.

1988 • 2 citations