Bleomycin: New Perspectives on the Mechanism of Action

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Mechanisms of bleomycin-induced DNA degradation

1987 • 869 citations

Chemical mechanisms of catalysis by cytochromes P-450: a unified view

1984 • 481 citations

Cleavage of Nucleic Acids by Bleomycin

1998 • 471 citations

Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.

1981 • 458 citations

A single mode of DNA base-pair opening drives imino proton exchange

1987 • 380 citations

CANCER CHEMOTHERAPEUTIC AGENTS

1996 • 271 citations

Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture

1991 • 222 citations

Sequence Selective Cleavage of a DNA Octanucleotide by Chlorinated Bithiazoles and Bleomycins

1998 • 219 citations

Induction of Gene Amplification by Arsenic

1988 • 215 citations

Bleomycin: Chemical, Biochemical, and Biological Aspects

1979 • 186 citations

Control of ring junction stereochemistry via radical cyclization

1985 • 182 citations

Bioorganic chemistry : nucleic acids

1996 • 174 citations

[Fe(PMA)]n+ (n = 1,2): good models of iron-bleomycins and examples of mononuclear non-heme iron complexes with significant oxygen-activation capabilities

1993 • 158 citations

RNA Degradation by Bleomycin, a Naturally Occurring Bioconjugate

1994 • 139 citations

The total synthesis of (+)-ionomycin

1990 • 137 citations

Binuclear oxygen carriers: hemerythrin

1984 • 127 citations

An active intermediate formed in the reaction of bleomycin-Fe(II) complex with oxygen.

1981 • 122 citations

Synthetic studies on antitumor antibiotic, bleomycin. 27. Man-designed bleomycin with altered sequence specificity in DNA cleavage

1990 • 112 citations

Synthesis of .beta.-lactams by the photolytic reaction of chromium carbene complexes with imines

1982 • 108 citations

Sequence-Specific Isotope Effects on the Cleavage of DNA by Bleomycin

1989 • 101 citations

Sequence-specific recognition and cleavage of DNA by metallobleomycin: minor groove binding and possible interaction mode.

1988 • 90 citations

Bleomycin as an oxene transferase. Catalytic oxygen transfer to olefins

1985 • 89 citations

Bleomycin Chemotherapy

1985 • 89 citations

Sequence specificity in photoreaction of various psoralen derivatives with DNA: role in biological activity

1988 • 86 citations

Tallysomycin, a new antitumor antibiotic complex related to bleomycin. II. Structure determination of tallysomycins A and B.

1977 • 84 citations

Chemistry of the alkali-labile lesion formed from iron(II) bleomycin and d(CGCTTTAAAGCG)

1988 • 83 citations

Interaction of Zn(II).cntdot.Bleomycin with d(CGCTAGCG)2. A Binding Model Based on NMR Experiments and Restrained Molecular Dynamics Calculations

1995 • 80 citations

Characterization of iron(II).cntdot.bleomycin-mediated RNA strand scission

1993 • 80 citations

DNA strand scission by bleomycin: catalytic cleavage and strand selectivity

1986 • 76 citations

Total synthesis of bleomycin A21)

1982 • 72 citations

The sequence specificity of bleomycin-induced DNA damage in intact cells.

1985 • 71 citations

Identification of the source of oxygen in the alkaline-labile product accompanying cytosine release during bleomycin-mediated oxidative degradation of d(CGCGCG)

1990 • 70 citations

Identification of the alkaline-labile product accompanying cytosine release during bleomycin-mediated degradation of d(CGCGCG)

1986 • 69 citations

Solution Structure of a Zn(II).cntdot.Bleomycin A5-d(CGCTAGCG)2 Complex

1994 • 66 citations

Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties.

1977 • 65 citations

Activation of oxygen and mediation of DNA degradation by manganese-bleomycin

1984 • 62 citations

Nitrocellulose filter binding studies of the interactions of Escherichia coli RNA polymerase holoenzyme with deoxyribonucleic acid restriction fragments: evidence for multiple classes of nonpromoter interactions, some of which display promoter-like properties

1982 • 53 citations

A facile synthesis of substituted N-hydroxy-2-azetidinones. A biogenetic type .beta.-lactam synthesis

1979 • 49 citations

Total Synthesis of Bleomycin Group Antibiotics. Total Syntheses of Bleomycin Demethyl A₂, Bleomycin A₂, and Decarbamoyl Bleomycin Demethyl A₂

1998 • 48 citations

Sequence-influenced interactions of oligoacridines with DNA detected by retarded gel electrophoretic migrations

1988 • 45 citations

A New Arrangement for the Anticancer Antibiotics Tallysomycin and Bleomycin When Bound to Zinc: An Assessment of Metal and Ligand Chirality by NMR and Molecular Dynamics

1997 • 45 citations

Mechanism of oxygenation of cis-stilbene by iron bleomycin

1987 • 44 citations

Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II).

1983 • 37 citations

Structure of the anthramycin-d(ATGCAT)2 adduct from one- and two-dimensional proton NMR experiments in solution

1985 • 36 citations

On the chemistry of RNA degradation by Fe·bleomycin

1997 • 35 citations

Multiple pathways in the oxidation of cis-stilbene by iron-bleomycin

1986 • 35 citations

Characterization of Zn(II)·Deglycobleomycin A₂ and Interaction with d(CGCTAGCG)₂: Direct Evidence for Minor Groove Binding of the Bithiazole Moiety

1998 • 34 citations

Influence of Chromatin Structure on Bleomycin−DNA Interactions at Base Pair Resolution in the Human β-Globin Gene Cluster

1996 • 33 citations

Synthesis of L-erythro-.beta.-hydroxyhistidine from D-glucosamine

1979 • 32 citations

Iron(II) Bleomycin-Mediated Degradation of a DNA-RNA Heteroduplex

1994 • 31 citations

Binuclear platinum(III) complexes. Preparation, structure, and d.sigma. .fwdarw. d.sigma.* spectrum of [Bu4N]2[Pt2(P2O5H2)4(CH3CN)2]

1986 • 31 citations

The conformation of single‐stranded nucleic acids

1990 • 30 citations

Utilization of the 6Li{1H} nuclear Overhauser effect. The structures of hydrido[tris(trimethylsilyl)methyl]metalates of boron, aluminum, gallium, and indium in solution

1986 • 29 citations

DNA damage induced by bleomycin in the presence of dibucaine is not predictive of cell growth inhibition

1985 • 29 citations

Differences between sites of binding to DNA and strand cleavage for complexes of bleomycin with iron of cobalt

1989 • 29 citations

The synthesis and functional evaluation of RNA and DNA polymers having the sequence of Escherichia coli tRNA^fMet

1989 • 29 citations

Fe.bleomycin as a probe of RNA conformation

1996 • 27 citations

DNA methylation diminishes bleomycin-mediated strand scission

1985 • 26 citations

Chemistry of bleomycin. XVII. Chemical proof for the .BETA.-lactam of bleomycin.

1977 • 25 citations

Proton exchange and epimerization of cobalt(III) chelated amino acids via carbanion intermediates

1990 • 23 citations

Bleomycins: Mechanism of Polynucleotide Recognition and Oxidative Degradation

1994 • 22 citations

Relation between the electronic structure and the condensation of metal clusters in M5X4 compounds

1984 • 21 citations

Dissociation of ‘hybrid’ isozymes on electrophoresis

1978 • 19 citations

[Kinetics of the action of the enzyme decapsulating Bacillus anthracis].

1968 • 15 citations

Increase in the C:N stretching frequency upon complexation of trans-retinylidenebutylamine with general Lewis acids

1986 • 15 citations

Nucleotide sequence cleavage of guanine-modified DNA with aflatoxin B1, dimethyl sulfate, and mitomycin C by bleomycin and deoxyribonuclease I

1983 • 15 citations

Determination of the absolute configuration of the thiazolinylthiazole moiety of phleomycin

1993 • 15 citations

Production of 2-octenyl radicals from the iron(III).cntdot.bleomycin-mediated fragmentation of 10-hydroperoxy-8,12-octadecadienoic acid

1991 • 10 citations

Telomers of bent arenes. Acid-catalyzed dimerization and trimerization of the 1,4-hexamethylene-bridged arenes [6]paracyclophane, [6](1,4)naphthalenophane, and [6](1,4)anthracenophane

1991 • 9 citations

SF-1771, a new antibiotic related to bleomycin.

1980 • 4 citations