Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice.

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Secretory products of macrophages.

1987 • 2,670 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages.

1990 • 237 citations

Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids

1991 • 189 citations

L-arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages.

1990 • 155 citations

Blood Flow Failure as a Major Determinant in the Antitumor Action of Flavone Acetic Acid

1989 • 151 citations

Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice.

1986 • 135 citations

Reduction of Tumor Blood Flow by Flavone Acetic Acid: A Possible Component of Therapy

1989 • 118 citations

Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy.

1988 • 104 citations

Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid.

1990 • 89 citations

Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma

1989 • 87 citations

Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic efficacy against murine renal cancer.

1990 • 66 citations

Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor α on Colon 38 tumours in mice

1989 • 64 citations

Synthesis and antitumor activity of some 8-substituted-4-oxo-4H-1-benzopyrans

1985 • 59 citations

Immunomodulation of Natural Killer Cell Activity by Flavone Acetic Acid: Occurrence Via Induction of Interferon /beta

1988 • 56 citations

Comparison of different forms of cadmium as reducing agents for the batch determination of nitrate

1978 • 56 citations

Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512)

1988 • 47 citations

Nitrat biosynthesis in rats, ferrets and humans. Precursor studies with L-arginine

1990 • 42 citations

Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts

1988 • 35 citations

Hyporesponsiveness of macrophages from (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512)

1989 • 12 citations

NITRIC OXIDE COMES OF AGE

1989 • 10 citations