bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy.

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Estimates of the worldwide frequency of sixteen major cancers in 1980

1988 • 1,073 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Cancer statistics, 1993

1993 • 983 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation

1984 • 671 citations

The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

1994 • 461 citations

Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.

1994 • 280 citations

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.

1993 • 262 citations

Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin.

1991 • 222 citations

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

1995 • 201 citations

Bcl‐2 proto‐oncogene expression in epstein‐barr‐virus‐associated nasopharyngeal carcinoma

1993 • 198 citations

Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.

1986 • 176 citations

Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy

1988 • 169 citations

BCL-2 expression in human colorectal adenomas and carcinomas.

1994 • 168 citations

Local control and patient survival

1992 • 145 citations

Risks of Head and Neck Surgery in Previously Irradiated Patients

1973 • 131 citations

Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma.

1995 • 79 citations

Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein.

1995 • 46 citations

Are postoperative complications more frequent and more serious after irradiation for laryngeal and hypopharyngeal cancer?

1984 • 16 citations