Photoimmune suppression and photocarcinogenesis

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB.

1980 • 983 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Platelet-Activating Factor and Related Lipid Mediators

2000 • 749 citations

Wavelengths effective in induction of malignant melanoma.

1993 • 739 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide

1993 • 615 citations

CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4

1997 • 612 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology.

1983 • 541 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

2001 • 525 citations

Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice.

1992 • 524 citations

Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2

1974 • 484 citations

Susceptibility to Effects of UVB Radiation on Induction of Contact Hypersensitivity as a Risk Factor for Skin Cancer in Humans

1990 • 436 citations

Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.

1988 • 421 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 • 413 citations

Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10.

1992 • 412 citations

Post-Transplant Malignancy

2000 • 408 citations

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.

1983 • 400 citations

Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis.

1977 • 400 citations

Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated Mice

1982 • 395 citations

Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice

2000 • 386 citations

Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study

2001 • 386 citations

UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion.

1992 • 374 citations

A Cytokine Cascade Including Prostaglandin E2, IL-4, and IL-10 Is Responsible for UV-Induced Systemic Immune Suppression

1998 • 351 citations

Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition

1999 • 334 citations

Immune suppression and skin cancer development: regulation by NKT cells

2000 • 327 citations

Cyclobutane Pyrimidine Dimers Are Responsible for the Vast Majority of Mutations Induced by UVB Irradiation in Mammalian Cells

2001 • 296 citations

Immunosuppression by ultraviolet B radiation: initiation by urocanic acid

1992 • 293 citations

Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin

2000 • 283 citations

Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation.

1989 • 252 citations

Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells.

1991 • 251 citations

Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes.

1996 • 249 citations

Mouse NK1.1+ T cells: a new family of T cells

1996 • 236 citations

Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release.

1995 • 236 citations

Dermal Mast Cells Determine Susceptibility to Ultraviolet B–induced Systemic Suppression of Contact Hypersensitivity Responses in Mice

1998 • 235 citations

Platelet-activating Factor, a Molecular Sensor for Cellular Damage, Activates Systemic Immune Suppression

2002 • 234 citations

Sunlight and skin cancer: Inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens

1997 • 230 citations

The role of IL-4, IL-10, and TNF-α in the immune suppression induced by ultraviolet radiation

1994 • 228 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis

1998 • 220 citations

IMMUNOLOGICAL EFFECTS OF SOLARIUM EXPOSURE

1983 • 204 citations

SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND ITS RELATIONSHIP TO UV-INDUCED SUPPRESSION OF TUMOR IMMUNITY

1981 • 203 citations

CD11b+ macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein.

1994 • 197 citations

cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-alpha.

1992 • 196 citations

Effects of ultraviolet radiation on human epidermal cell alloantigen presentation: initial depression of Langerhans cell-dependent function is followed by the appearance of T6- Dr+ cells that enhance epidermal alloantigen presentation.

1985 • 189 citations

Further Studies on the Tumor-Specific Suppressor Cells Induced by Ultraviolet Radiation

1978 • 189 citations

Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells.

1994 • 176 citations

Low dose ultraviolet B-irradiated Langerhans cells preferentially activate CD4+ cells of the T helper 2 subset.

1990 • 171 citations

Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation.

1995 • 166 citations

Apoptosis, the Role of Oxidative Stress and the Example of Solar UV Radiation

1999 • 163 citations

Topical Treatment with Liposomes Containing T4 Endonuclease V Protects Human Skin In Vivo from Ultraviolet-Induced Upregulation of Interleukin-10 and Tumor Necrosis Factor-α

2000 • 162 citations

Green Tea and Skin—Anticarcinogenic Effects

1994 • 158 citations

Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice.

1992 • 155 citations

Biologically Active Oxidized Phospholipids

1999 • 154 citations

Epidermaltrans-urocanic acid and the UV-A-induced photoaging of the skin

1998 • 152 citations

Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice.

1996 • 147 citations

The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored byin vitrophotorepair of cyclobutane pyrimidine dimers

1997 • 144 citations

Ultraviolet radiation and skin cancer of humans

1997 • 143 citations

Antigen-Presenting OKM5+ Melanophages Appear in Human Epidermis After Ultraviolet Radiation

1986 • 143 citations

Localization of Liposomes Containing a DNA Repair Enzyme in Murine Skin

1994 • 142 citations

Interleukin-12 Prevents Ultraviolet B-Induced Local Immunosuppression and Overcomes UVB-Induced Tolerance

1996 • 139 citations

THE ROLE OF UROCANIC ACID IN UV‐INDUCED IMMUNOSUPPRESSION: RECENT ADVANCES (1992–1994)

1995 • 138 citations

THE ROLE OF EPIDERMAL CYTOKINES IN THE GENERATION OF CUTANEOUS IMMUNE REACTIONS and ULTRAVIOLET RADIATION‐INDUCED IMMUNE SUPPRESSION

1995 • 137 citations

Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide.

1995 • 134 citations

Activation of the Epidermal Platelet-Activating Factor Receptor Results in Cytokine and Cyclooxygenase-2 Biosynthesis

1998 • 129 citations

Ultraviolet-Irradiated Urocanic Acid Suppresses Delayed-Type Hypersensitivity to Herpes Simplex Virus in Mice

1986 • 127 citations

Broad-Spectrum Sunscreens Provide Greater Protection against Ultraviolet-Radiation–Induced Suppression of Contact Hypersensitivity to a Recall Antigen in Humans

1997 • 126 citations

MODIFICATION OF IMMUNOLOGICAL POTENTIAL BY ULTRAVIOLET RADIATION

1977 • 122 citations

Activated Complement Component 3 (C3) Is Required for Ultraviolet Induction of Immunosuppression and Antigenic Tolerance

1998 • 114 citations

Ultraviolet A Radiation Suppresses an Established Immune Response: Implications for Sunscreen Design

2001 • 111 citations

Calcitonin gene-related peptide is necessary for ultraviolet B-impaired induction of contact hypersensitivity.

1997 • 110 citations

Mechanisms in the suppression of tumor rejection produced in mice by repeated UV irradiation.

1984 • 107 citations

In Human Skin, UVB Initiates Early Induction of IL-10 Over IL-12 Preferentially in the Expanding Dermal Monocytic/Macrophagic Population

1998 • 101 citations

Contrasting effects of ultraviolet A1 and ultraviolet B exposure on the induction of tumour necrosis factor‐α in human skin

1998 • 100 citations

Ultraviolet A Radiation (320–400 nm) Protects Hairless Mice from Immunosuppression Induced by Ultraviolet B Radiation (280–320 nm) or <i>Cis-</i>Urocanic Acid

1998 • 98 citations

Neutrophils, Differentiated Macrophages, and Monocyte/Macrophage Antigen Presenting Cells Infiltrate Murine Epidermis After UV Injury

1993 • 97 citations

Evidence for the generation of suppressor cells by ultraviolet radiation

1977 • 96 citations

Hapten-Specific Tolerance Induced by Acute, Low-Dose Ultraviolet B Radiation of Skin Is Mediated via Interleukin-10

1997 • 94 citations

Cis‐UROCANIC ACID SYNERGIZES WITH HISTAMINE FOR INCREASED PGE₂ PRODUCTION BY HUMAN KERATINOCYTES: LINK TO INDOMETHACIN‐INHIBITABLE UVB‐INDUCED IMMUNOSUPPRESSION

1995 • 94 citations

Human epidermal cells from ultraviolet light-exposed skin preferentially activate autoreactive CD4+2H4+ suppressor-inducer lymphocytes and CD8+ suppressor/cytotoxic lymphocytes.

1988 • 93 citations

Vitamin C Abrogates the Deleterious Effects of UVB Radiation on Cutaneous Immunity by a Mechanism That Does Not Depend on TNF-α

1997 • 92 citations

TOPICAL UROCANIC ACID ENHANCES UV‐INDUCED TUMOUR YIELD AND MALIGNANCY IN THE HAIRLESS MOUSE

1989 • 89 citations

Mechanisms of depressed reactivity to dinitrochlorobenzene and ultraviolet-induced tumors during ultraviolet carcinogenesis in BALB/c mice

1978 • 88 citations

Identification of Functional Platelet-Activating Factor Receptors on Human Keratinocytes

1995 • 87 citations

Effector and suppressor circuits of the immune response are activated in vivo by different mechanisms.

1987 • 83 citations

Broad-Spectrum Sunscreens Provide Better Protection from the Suppression of the Elicitation Phase of Delayed-Type Hypersensitivity Response in Humans

2001 • 82 citations

Expression of the Platelet-activating Factor Receptor Results in Enhanced Ultraviolet B Radiation-induced Apoptosis in a Human Epidermal Cell Line

1998 • 80 citations

Chronic Low-Dose UVA Irradiation Induces Local Suppression of Contact Hypersensitivity, Langerhans Cell Depletion and Suppressor Cell Activation in C3H/HeJ Mice

1996 • 80 citations

Histamine involvement in UVB‐ and cis‐urocanic acid‐induced systemic suppression of contact hypersensitivity responses

1997 • 78 citations

A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation

1999 • 77 citations

Reversal of immunosuppression inducible through ultraviolet-exposed skin by in vivo anti-CD11b treatment.

1996 • 77 citations

Active induction of unresponsiveness (tolerance) to DNFB by in vivo ultraviolet-exposed epidermal cells is dependent upon infiltrating class II MHC+ CD11bbright monocytic/macrophagic cells.

1994 • 76 citations

Differential effects of a monoclonal antibody to cis-urocanic acid on the suppression of delayed and contact hypersensitivity following ultraviolet irradiation.

1996 • 75 citations

Ultraviolet Light-Induced Immune Tolerance Is Mediated via the Fas/Fas-Ligand System

1998 • 74 citations

Local and systemic effect of ultraviolet irradiation (UVB and UVA) on human allergic contact dermatitis

1986 • 71 citations

A Monoclonal Antibody to cis-Urocanic Acid Prevents the Ultraviolet-Induced Changes in Langerhans Cells and Delayed Hypersensitivity Responses in Mice, Although Not Preventing Dendritic Cell Accumulation in Lymph Nodes Draining the Site of Irradiation and Contact Hypersensitivity Responses

1995 • 70 citations

Modulation of IL-10, IL-12, and IFN-γ in the Epidermis of Hairless Mice by UVA (320–400 nm) and UVB (280–320 nm) Radiation

1999 • 69 citations

UVA II Exposure of Human Skin Results in Decreased Immunization Capacity, Increased Induction of Tolerance and a Unique Pattern of Epidermal Antigen‐Presenting Cell Alteration

1997 • 68 citations

Contrasting effects of ultraviolet-A and ultraviolet-B exposure on induction of contact sensitivity in human skin

1997 • 67 citations

HYDROGEN PEROXIDE MEDIATES UV‐INDUCED IMPAIRMENT OF ANTIGEN PRESENTATION IN A MURINE EPIDERMAL‐DERIVED DENDRITIC CELL LINE

1995 • 66 citations

A Role for Neuropeptides in UVB‐Induced Systemic Immunosuppression

1998 • 65 citations

Ultraviolet light-induced G2 phase cell cycle checkpoint blocks cdc25-dependent progression into mitosis

1997 • 65 citations

Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals

1997 • 64 citations

UV-DNA Damage in Mouse and Human Cells Induces the Expression of Tumor Necrosis Factor α

1998 • 64 citations

Tumor necrosis factor-alpha and ultraviolet B light have similar effects on contact hypersensitivity in mice.

1990 • 64 citations

Inhibition of Solar Simulator-Induced p53 Mutations and Protection Against Skin Cancer Development in Mice by Sunscreens

1999 • 63 citations

Ultraviolet Radiation Induced Suppression of Mantoux Reactions in Humans

1998 • 63 citations

Characterization of a monoclonal antibody to cis-urocanic acid: detection of cis-urocanic acid in the serum of irradiated mice by immunoassay.

1993 • 62 citations

Exposure to Ultraviolet Radiation Causes Dendritic Cells/Macrophages to Secrete Immune-Suppressive IL-12p40 Homodimers

2000 • 61 citations

Regulation of tumor antigen presentation by urocanic acid.

1997 • 61 citations

Interferon-γ is Involved in Photoimmunoprotection by UVA (320–400 nm) Radiation in Mice

1999 • 59 citations

<i>cis</i>-Urocanic Acid Induces Mast Cell Degranulation and Release of Preformed TNF--α: A Possible Mechanism Linking UVB and <i>cis</i>-Urocanic Acid to Immunosuppression of Contact Hypersensitivity

1999 • 58 citations

Photoreactivation of ultraviolet radiation-induced skin and eye tumors of Monodelphis domestica.

1991 • 57 citations

Reversal of ultraviolet radiation‐induced immune suppression by recombinant interleukin‐12: suppression of cytokine production

2000 • 57 citations

Suppression of Natural Killer Cell Activity in Humans by Radiation from Solarium Lamps Depleted of UVB

1988 • 56 citations

Suppression of the immune response to alloantigen by factors released from ultraviolet-irradiated keratinocytes.

1990 • 56 citations

UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins

1998 • 55 citations

Improved Protection Against Solar-Simulated Radiation-Induced Immunosuppression by a Sunscreen with Enhanced Ultraviolet A Protection

2000 • 55 citations

High Dermal Mast Cell Prevalence is a Predisposing Factor for Basal Cell Carcinoma in Humans

2000 • 54 citations

Urocanic acid enhances IL-10 production in activated CD4+ T cells.

1998 • 51 citations

DNA double strand breaks in epidermal cells cause immune suppression in vivo and cytokine production in vitro.

1996 • 50 citations

Suppression of Delayed and Contact Hypersensitivity Responses in Mice Have Different UV Dose Responses

1998 • 46 citations

Local Ultraviolet B Irradiation Impairs Contact Hypersensitivity Induction by Triggering Release of Tumor Necrosis Factor-α from Mast Cells. Involvement of Mast Cells and Langerhans Cells in Susceptibility to Ultraviolet B

1999 • 44 citations

Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin requires mast cell degranulation

2001 • 43 citations

Temporal Correlation Between UV Radiation Locally-Inducible Tolerance and the Sequential Appearance of Dermal, Then Epidermal, Class II MHC+CD11b+ Monocytic/Macrophagic Cells

1996 • 43 citations

Risk assessment for the harmful effects of UVB radiation on the immunological resistance to infectious diseases.

1998 • 42 citations

Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity.

1990 • 42 citations

Ultraviolet-irradiated apoptotic lymphocytes produce interleukin-10 by themselves

2000 • 38 citations

Cis‐UROCANIC ACID DOWN‐REGULATES THE INDUCTION OF ADENOSINE 3', 5'‐CYCLIC MONOPHOSPHATE BY EITHER trans‐UROCANIC ACID OR HISTAMINE IN HUMAN DERMAL FIBROBLASTS in vitro

1992 • 37 citations

SUPPRESSION OF THE INDUCTION OF DELAYED‐TYPE HYPERSENSITIVITY REACTIONS IN MICE BY A SINGLE EXPOSURE TO ULTRAVIOLET RADIATION

1986 • 37 citations

Topically applied N-acetylcysteine as a protector against UVB-induced systemic immunosuppression

1995 • 36 citations

Hapten-Specific Tolerance Promoted by Calcitonin Gene-Related Peptide

2000 • 32 citations

Splenic NK1.1-negative, TCR alpha beta intermediate CD4+ T cells exist in naive NK1.1 allelic positive and negative mice, with the capacity to rapidly secrete large amounts of IL-4 and IFN-gamma upon primary TCR stimulation.

1999 • 29 citations

Ultraviolet B-Exposed and Soluble Factor-Pre-Incubated Epidermal Langerhans Cells Fail to Induce Contact Hypersensitivity and Promote DNP-Specific Tolerance

1997 • 27 citations

Two Phenotypically Distinct T Cells Are Involved in Ultraviolet-Irradiated Urocanic Acid-Induced Suppression of the Efferent Delayed-Type Hypersensitivity Response to Herpes Simplex Virus, Type 1 In Vivo

1987 • 27 citations

Release of platelet activating factor (PAF) and eicosanoids in UVC-irradiated corneal stromal cells

1995 • 25 citations

The Effects of Ultraviolet Radiation on the Immune System

1984 • 24 citations

Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin

1988 • 22 citations

HindIII Liposomes Suppress Delayed-Type Hypersensitivity Responses In Vivo and Induce Epidermal IL-10 In Vitro

1998 • 21 citations

cis-Urocanic Acid does not Induce the Expression of Immunosuppressive Cytokines in Murine Keratinocytes¶†

2001 • 19 citations

UVB-induced experimental carcinogenesis: dysregulation of apoptosis and p53 signalling pathway

2000 • 16 citations

Studies on delayed systemic effects of ultraviolet B radiation on the induction of contact hypersensitivity, 3. Dendritic cells from secondary lymphoid organs are deficient in interleukin‐12 production and capacity to promote activation and differentiation of T helper type 1 cells

2000 • 15 citations

Low expression of CD40 and B7 on macrophages infiltrating UV-exposed human skin; role in IL-2Rα− T cell activation

1998 • 14 citations

Effects of UV Radiation on Infectious Diseases

1992 • 4 citations