Immunosuppression by ultraviolet B radiation: initiation by urocanic acid

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology.

1983 • 541 citations

Suppressor T Lymphocytes Control the Development of Primary Skin Cancers in Ultraviolet-Irradiated Mice

1982 • 395 citations

Identification of the molecular target for the suppression of contact hypersensitivity by ultraviolet radiation.

1989 • 252 citations

Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells.

1991 • 251 citations

The Blue Light Syndrome

1980 • 248 citations

IMMUNOLOGICAL EFFECTS OF SOLARIUM EXPOSURE

1983 • 204 citations

SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND ITS RELATIONSHIP TO UV-INDUCED SUPPRESSION OF TUMOR IMMUNITY

1981 • 203 citations

Cis-Urocanic Acid, a Product formed by Ultraviolet B Irradiation of the Skin, Initiates and Antigen Presentation Defect in Splenic Dendritic Cells In Vivo

1988 • 164 citations

Mechanism of systemic immune suppression by UV irradiation in vivo. II. The UV effects on number and morphology of epidermal Langerhans cells and the UV-induced suppression of contact hypersensitivity have different wavelength dependencies.

1984 • 143 citations

SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND ITS RELATIONSHIP TO UV-INDUCED SUPPRESSION OF TUMOR IMMUNITY

1981 • 130 citations

Ultraviolet-Irradiated Urocanic Acid Suppresses Delayed-Type Hypersensitivity to Herpes Simplex Virus in Mice

1986 • 127 citations

The metabolism and function of urocanic acid in skin.

1967 • 127 citations

Suppression of pathogenesis in cutaneous leishmaniasis by UV irradiation

1986 • 121 citations

The Metabolism and Function of Urocanic Acid in Skin**From the Harvard Medical School, Department of Dermatology, and the Dermatology Service at the Massachusetts General Hospital, Boston, Massachusetts 02114.

1967 • 116 citations

ULTRAVIOLET‐B DOSE‐RESPONSE CURVES FOR LOCAL AND SYSTEMIC IMMUNOSUPPRESSION ARE IDENTICAL

1990 • 100 citations

Effects of Ultraviolet B Light on Cutaneous Immune Responses of Humans with Deeply Pigmented Skin

1991 • 97 citations

Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis and the resulting accumulation of urocanic acid

1981 • 96 citations

UROCANIC ACID AND IMMUNOSUPPRESSION

1989 • 95 citations

WAVELENGTH DEPENDENCE AND DOSE‐RATE INDEPENDENCE OF UV RADIATION‐INDUCED IMMUNOLOGIC UNRESPONSIVENESS OF MICE TO A UV‐INDUCED FIBROSARCOMA

1980 • 95 citations

Human epidermal cells from ultraviolet light-exposed skin preferentially activate autoreactive CD4+2H4+ suppressor-inducer lymphocytes and CD8+ suppressor/cytotoxic lymphocytes.

1988 • 93 citations

MODIFICATION OF IMMUNOLOGICAL POTENTIAL BY ULTRAVIOLET RADIATION

1977 • 90 citations

TOPICAL UROCANIC ACID ENHANCES UV‐INDUCED TUMOUR YIELD AND MALIGNANCY IN THE HAIRLESS MOUSE

1989 • 89 citations

Effect of a single exposure to ultraviolet radiation on Mycobacterium bovis bacillus Calmette-Guerin infection in mice.

1989 • 84 citations

DOSE‐RESPONSE CHARACTERISTICS OF IMMUNOLOGIC UNRESPONSIVENESS TO UV‐INDUCED TUMORS PRODUCED BY UV IRRADIATION OF MICE

1979 • 79 citations

Z/E PHOTOISOMERIZATION OF UROCANIC ACID*

1980 • 78 citations

BIOLOGICALLY EFFECTIVE DOSES OF SUNLIGHT FOR IMMUNE SUPPRESSION AT VARIOUS LATITUDES AND THEIR RELATIONSHIP TO CHANGES IN STRATOSPHERIC OZONE

1990 • 64 citations

Immunomodulation by ultraviolet light: clinical studies and biological effects

1991 • 61 citations

The effect of histamine receptor antagonists on immunosuppression induced by the cis-isomer of urocanic acid.

1990 • 55 citations

Laboratory Methods in Immunology

1990 • 53 citations

Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid.

1988 • 48 citations

DIETARY HISTIDINE INCREASES MOUSE SKIN UROCANIC ACID LEVELS AND ENHANCES UVB‐INDUCED IMMUNE SUPPRESSION OF CONTACT HYPERSNSITIVITY

1991 • 40 citations

Cis‐UROCANIC ACID DOWN‐REGULATES THE INDUCTION OF ADENOSINE 3', 5'‐CYCLIC MONOPHOSPHATE BY EITHER trans‐UROCANIC ACID OR HISTAMINE IN HUMAN DERMAL FIBROBLASTS in vitro

1992 • 37 citations

A single dose of UV radiation suppresses delayed type hypersensitivity responses to alloantigens and prolongs heart allograft survival in mice

1988 • 27 citations

Photochemical covalent binding of urocanic acid to polynucleic acids

1990 • 22 citations

New trends in photobiology photoimmunology: The mechanisms involved in immune modulation by UV radiation

1988 • 20 citations

THE EFFECT OF THE ANTIHISTAMINE CIMETIDINE ON ULTRAVIOLET‐RADIATION‐INDUCED TUMORIGENESIS IN THE HAIRLESS MOUSE

1991 • 18 citations

Photoreactivation in humans

1991 • 16 citations

Inhibition of rat heart allograft rejection by a PUVA treatment of the graft recipient

1990 • 16 citations

TRANSFER OF IMMUNOLOGICAL TOLERANCE TO ULTRAVIOLET-RADIATIONINDUCED SKIN TUMORS WITH GRAFTS OF ULTRAVIOLET-IRRADIATED SKIN

1983 • 13 citations

Transfer of immunological tolerance to ultraviolet-radiation-induced skin tumors with grafts of ultraviolet-irradiated skin.

1983 • 13 citations

Urocanic acid isomers in epidermal samples and suction blister fluid of nonirradiated and UVB-irradiated human skin.

1990 • 12 citations