Comparative proteome analysis of Helicobacter pylori

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1996 • 8,994 citations

UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION

1984 • 5,344 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

The complete genome sequence of the gastric pathogen Helicobacter pylori

1997 • 3,529 citations

Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro

1997 • 2,492 citations

Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

1999 • 1,904 citations

Helicobacter pyloriInfection and Gastric Carcinoma among Japanese Americans in Hawaii

1991 • 1,769 citations

Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

1991 • 1,399 citations

Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging

1998 • 1,182 citations

A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain

1997 • 919 citations

Two‐dimensional electrophoresis of proteins: An updated protocol and implications for a functional analysis of the genome

1995 • 724 citations

Analyses of the cag pathogenicity island of Helicobacter pylori

1998 • 714 citations

Purification and characterization of the vacuolating toxin from Helicobacter pylori.

1992 • 700 citations

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori

1997 • 649 citations

Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin

1995 • 594 citations

Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

1994 • 594 citations

Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin

1999 • 591 citations

Development of a Mouse Model of Helicobacter pylori Infection that Mimics Human Disease

1995 • 574 citations

Functions of the gene products of Escherichia coli

1993 • 330 citations

Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens

1999 • 328 citations

Characterization of a Helicobacter pylori neutrophil-activating protein

1995 • 317 citations

Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization

1993 • 257 citations

The Interrelationship between Cytotoxin-Associated Gene A, Vacuolating Cytotoxin, and Helicobacter pylori-Related Diseases

1996 • 256 citations

Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease

1994 • 248 citations

Genetic and functional characterization of the alpAB gene locus essential for the adhesion of Helicobacter pylori to human gastric tissue

1999 • 245 citations

Ueber die schlauchförmigen Drüsen des Magendarmkanals und die Beziehungen ihres Epithels zu dem Oberflächenepithel der Schleimhaut Dritte Mittheilung

1893 • 237 citations

Proteome research: Complementarity and limitations with respect to the RNA and DNA worlds

1997 • 218 citations

Low pH Activates the Vacuolating Toxin of Helicobacter pylori, Which Becomes Acid and Pepsin Resistant

1995 • 217 citations

Cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of Helicobacter pylori

1993 • 210 citations

Helicobacter pylori requires an acidic environment to survive in the presence of urea

1995 • 188 citations

Diagnosis of Helicobacter pylori infection by PCR: comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens

1995 • 181 citations

Analysis of changes in acute‐phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two‐dimensional gel electrophoresis

1998 • 180 citations

Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant

1998 • 172 citations

Variability of gene order in different Helicobacter pylori strains contributes to genome diversity

1996 • 156 citations

Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B

1998 • 149 citations

Functions of the gene products of Escherichia coli.

1993 • 148 citations

Analysis of high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells

1990 • 139 citations

Catalase, a novel antigen for Helicobacter pylori vaccination

1997 • 137 citations

Characterization of the Helicobacter pylori urease and purification of its subunits

1991 • 134 citations

Identification of mouse brain proteins after two‐dimensional electrophoresis and electroblotting by microsequence analysis and amino acid composition analysis

1988 • 132 citations

Identification of Immunodominant Antigens from Helicobacter pylori and Evaluation of Their Reactivities with Sera from Patients with Different Gastroduodenal Pathologies

2000 • 130 citations

Identification of human myocardial proteins separated by two‐dimensional electrophoresis using an effective sample preparation for mass spectrometry

1996 • 127 citations

Efficacy and optimum dose of omeprazole in a new 1-week triple therapy regimen to eradicate Helicobacter pylori.

1995 • 126 citations

Mechanisms of Helicobacter pylori Infection: Bacterial Factors

1999 • 119 citations

Protein Hpn: cloning and characterization of a histidine-rich metal-binding polypeptide in Helicobacter pylori and Helicobacter mustelae

1995 • 118 citations

Cloning and genetic characterization of Helicobacter pylori catalase and construction of a catalase-deficient mutant strain

1996 • 116 citations

How Should Helicobacter pylori Infection Be Diagnosed?

1997 • 105 citations

IgG immune response toHelicobacter pylori antigens in patients with gastric cancer as defined by ELISA and immunoblotting

1996 • 105 citations

Immunoblot assay for serodiagnosis of Helicobacter pylori infections

1997 • 105 citations

Protein composition of the human heart: The construction of a myocardial two‐dimensional electrophoresis database

1994 • 103 citations

Antibody-Secreting Cells in the Stomachs of Symptomatic and AsymptomaticHelicobacter pylori-Infected Subjects

1998 • 102 citations

Protein Reverse Staining: High-Efficiency Microanalysis of Unmodified Proteins Detected on Electrophoresis Gels

1995 • 97 citations

Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: evidence for a third class of ferritins

1993 • 87 citations

The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin

1993 • 87 citations

Characterization of Helicobacter pylori urease mutants

1992 • 85 citations

Blotting efficiency investigated by using two‐dimensional electrophoresis, hydrophobic membranes and proteins from different sources

1990 • 85 citations

Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: Towards an integrated protein database

1990 • 71 citations

A dynamic two-dimensional polyacrylamide gel electrophoresis database: The mycobacterial proteomevia Internet

1999 • 69 citations

Two-dimensional gel electrophoresis and immunoblotting of Campylobacter pylori proteins

1989 • 64 citations

High‐performance human myocardial two‐dimensional electrophoresis database: Edition 1996

1996 • 62 citations

Comprehensive detection of immunorelevantBorrelia garinii antigens by two-dimensional electrophoresis

1999 • 62 citations

Identification of Potential Diagnostic and Vaccine Candidates of Helicobacter pylori by Two-Dimensional Gel Electrophoresis, Sequence Analysis, and Serum Profiling

1998 • 61 citations

Identification of Virulence Genes of Helicobacter pylori by Random Insertion Mutagenesis

1999 • 57 citations

Cloning and Characterization of Helicobacter pyloriSuccinyl CoA:Acetoacetate CoA-transferase, a Novel Prokaryotic Member of the CoA-transferase Family

1997 • 56 citations

Naturally acquired human immune responses againstHelicobacter pylori and implications for vaccine development

1999 • 55 citations

Use of Immunoblot Assay To Define Serum Antibody Patterns Associated with Helicobacter pylori Infection and with H. pylori -Related Ulcers

1998 • 50 citations

Identification of potential diagnostic and vaccine candidates of Helicobacter pylori by "proteome" technologies.

1998 • 46 citations

Seroprevalence of eight Helicobacter pylori antigens among 182 patients with peptic ulcer, MALT gastric lymphoma or non-ulcer dyspepsia. Higher rate of seroreactivity against CagA and 35-kDa antigens in patients with peptic ulcer originating from Europe and Africa

1999 • 38 citations

The attenuated Salmonella vaccine approach for the control of Helicobacter pylori-related diseases

1999 • 37 citations

Characterization of a Helicobacter pylori vaccine candidate by proteome techniques

1998 • 35 citations

Vaccine development against infection with Helicobacter pylori

1998 • 30 citations

Urease-positive, acid-sensitive mutants ofHelicobacter pylori:urease-independent acid resistance involved in growth at low pH

1998 • 27 citations

Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae

1995 • 25 citations

Eradication of chronic Helicobacter pylori infection by therapeutic vaccination

1998 • 21 citations

Humoral immune response against Helicobacter pylori as determined by immunoblot

1993 • 20 citations

Serodiagnosis ofHelicobacter pylori infections by detection of immunoglobulin G antibodies using an immunoblot technique and enzyme immunoassay

1992 • 19 citations

Protection againstHelicobacter pyloriinfection by intestinal immunisation with a 50/52-kDa subunit protein

1999 • 16 citations