Compartmentalization of the immune response in the central nervous system and natural history of multiple sclerosis. Implications for therapy

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Fundamental Immunology

1999 • 1,011 citations

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

2000 • 918 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology

1997 • 517 citations

Monocyte/macrophage differentiation in early multiple sclerosis lesions

1995 • 513 citations

Immunopathology of secondary‐progressive multiple sclerosis

2001 • 416 citations

Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis

1993 • 378 citations

The neuropathology of multiple sclerosis.

2000 • 332 citations

A Textbook of Neuropathology

1950 • 325 citations

Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

1998 • 321 citations

Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: Increased yield of active demyelinating and (p)reactive lesions

2001 • 278 citations

Intracerebral Recruitment and Maturation of Dendritic Cells in the Onset and Progression of Experimental Autoimmune Encephalomyelitis

2000 • 251 citations

Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis

1993 • 249 citations

Accumulation of Clonally Related B Lymphocytes in the Cerebrospinal Fluid of Multiple Sclerosis Patients

2000 • 247 citations

Two subsets of dendritic cells are present in human cerebrospinal fluid

2001 • 237 citations

T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms

1997 • 165 citations

Histopathological Characterization of Magnetic Resonance Imaging-Detectable Brain White Matter Lesions in a Primate Model of Multiple Sclerosis

1998 • 145 citations

A new primate model for multiple sclerosis in the common marmoset

2000 • 112 citations

Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis: evidence for distinct mechanisms of lesion genesis?

1999 • 98 citations

T1 lesion load and cerebral atrophy as a marker for clinical progression in patients with multiple sclerosis. A prospective 18 months follow‐up study

2001 • 94 citations

[Neuropathology of multiple sclerosis].

2015 • 83 citations

Prognosis with dementia in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.

2000 • 80 citations

Mechanisms of demyelination and tissue destruction in multiple sclerosis

2002 • 59 citations

Textbook of Neuropathology

1992 • 47 citations

Correlation of magnetic resonance imaging parameters with clinical disability in multiple sclerosis: a preliminary study

1999 • 41 citations

The lesion in multiple sclerosis: clinical, pathological, and magnetic resonance imaging considerations.

1998 • 37 citations

EXPERIMENTAL CONGENITAL TOXOPLASMOSIS

1950 • 25 citations

Utilidad clínica de las bandas oligoclonales

2001 • 17 citations

Oligoclonal T cell repertoire in cerebrospinal fluid of patients with inflammatory diseases of the nervous system

2001 • 10 citations