Effect of High Dose Folic Acid Therapy on Hyperhomocysteinemia in Hemodialysis Patients

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

1998 • 1,569 citations

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

1998 • 1,283 citations

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1987 • 1,072 citations

Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology, and potential relationship to arteriosclerotic outcomes

1997 • 457 citations

Prospective Study of Hyperhomocysteinemia as an Adverse Cardiovascular Risk Factor in End-Stage Renal Disease

1998 • 412 citations

A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells

1998 • 385 citations

Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations

1997 • 346 citations

Hyperhomocysteinemia Confers an Independent Increased Risk of Atherosclerosis in End-Stage Renal Disease and Is Closely Linked to Plasma Folate and Pyridoxine Concentrations

1996 • 339 citations

Elevated Fasting Total Plasma Homocysteine Levels and Cardiovascular Disease Outcomes in Maintenance Dialysis Patients

1997 • 299 citations

The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

1997 • 277 citations

High dose B-vitamin treatment of hyperhomocysteinemia in dialysis patients

1996 • 242 citations

Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients.

1993 • 225 citations

Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: Possible implications for prevention of vascular disease

1988 • 197 citations

Folic acid safety and toxicity: a brief review

1989 • 178 citations

Hyperhomocysteinemia and the risk for vascular disease in hemodialysis patients.

1995 • 173 citations

The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients.

1993 • 154 citations

Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients

1997 • 129 citations

No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in haemodialysis patients

1998 • 108 citations

Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia.

1997 • 98 citations

Major determinants of hyperhomocysteinemia in peritoneal dialysis patients

1998 • 81 citations

Response of hyperhomocysteinemia to folic acid supplementation in patients with end-stage renal disease.

1999 • 72 citations

Folic acid treatment of hyperhomocysteinemia in dialysis patients.

1996 • 67 citations

Chairman's workshop report. Is there a role for adjuvant therapy in patients being treated with epoetin?

1999 • 66 citations

Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients

1999 • 65 citations

Cardiovascular morbidity and endothelial dysfunction in chronic haemodialysis patients: is homocyst(e)ine the missing link?

1999 • 60 citations

Effects of High-Dose Folic Acid and Pyridoxine on Plasma and Erythrocyte Sulfur Amino Acids in Hemodialysis Patients

1999 • 60 citations

The Role of Homocysteine in End‐Stage Renal Disease

1998 • 25 citations

Homocysteine, lipoprotein(a) and fibrinogen

1998 • 24 citations

Hyperhomocysteinemia: detection, risk assessment, and treatment

1997 • 20 citations

Sulfur amino acids in maintenance hemodialysis patients.

1987 • 14 citations