In Vivo Recognition by the Host Adaptive Immune System of Microencapsulated Xenogeneic Cells

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

2000 • 1,175 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Cell encapsulation: Promise and progress

2003 • 580 citations

Heat Shock Proteins as Ligands of Toll-Like Receptors

2002 • 274 citations

Regulation of the Immune Response by Antigen

2001 • 252 citations

Considerations for successful transplantation of encapsulated pancreatic islets

2002 • 248 citations

Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity

2003 • 243 citations

Tracking Salmonella-Specific CD4 T Cells In Vivo Reveals a Local Mucosal Response to a Disseminated Infection

2002 • 226 citations

Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

2003 • 202 citations

ARE Th2 HELPER T LYMPHOCYTES BENEFICIAL, DELETERIOUS, OR IRRELEVANT IN PROMOTING ALLOGRAFT SURVIVAL?1

1997 • 170 citations

Immunoisolated Xenogeneic Chromaffin Cell Therapy for Chronic Pain

1996 • 136 citations

Nitric oxide and T helper cell immunity

2001 • 134 citations

Long-term biocompatibility, chemistry, and function of microencapsulated pancreatic islets

2002 • 130 citations

TRANSPLANTATION OF ALGINATE MICROCAPSULES

1999 • 127 citations

THE ROLE OF CD4+ HELPER T CELLS IN THE DESTRUCTION OF MICROENCAPSULATED ISLET XENOGRAFTS IN NOD MICE

1990 • 127 citations

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

2001 • 124 citations

Tissue Engineering Methods and Protocols

2000 • 113 citations

Intragraft expression of cytokine transcripts during pig proislet xenograft rejection and tolerance in mice.

1995 • 91 citations

CD4+ T CELL MEDIATED DESTRUCTION OF XENOGRAFTS WITHIN CELL-IMPERMEABLE MEMBRANES IN THE ABSENCE OF CD8+ T CELLS AND B CELLS1

1996 • 90 citations

CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines.

1993 • 76 citations

Complement-Fixing Elicited Antibodies Are a Major Component in the Pathogenesis of Xenograft Rejection

1998 • 76 citations

XENOGENEIC HUMORAL RESPONSES TO ISLETS TRANSPLANTED IN BIOHYBRID DIFFUSION CHAMBERS

1994 • 69 citations

Nitric Oxide Inhibits the Proliferation of T-Helper 1 and 2 Lymphocytes without Reduction in Cytokine Secretion

1999 • 66 citations

Macrophage-Derived Nitric Oxide Inhibits the Proliferation of Activated T Helper Cells and Is Induced during Antigenic Stimulation of Resting T Cells

2000 • 62 citations

Colorimetric assay fop cellular activity in microcapsules

1990 • 60 citations

Sustained Expression of High Levels of Human Factor IX from Human Cells Implanted within an Immunoisolation Device into Athymic Rodents

1998 • 49 citations

Encapsulated islet cells: the role of direct and indirect presentation and the relevance to xenotransplantation and autoimmune recurrence

1997 • 48 citations

EVIDENCE FOR EARLY Th 2 T CELL PREDOMINANCE IN XENOREACTIVITY

1993 • 47 citations

A Distinct Th1 Immune Response Precedes the Described Th2 Response in Islet Xenograft Rejection

2002 • 46 citations

Therapeutic Potential of a Polymer-Encapsulated ?-DOPA and Dopamine-Producing Cell Line in Rodent and Primate Models of Parkinson's Disease

1998 • 40 citations

T cell response in xenorecognition and xenografts: a review

1999 • 38 citations

Microencapsulation and tissue engineering as an alternative treatment of diabetes

2001 • 37 citations

IMMUNE MECHANISMS ASSOCIATED WITH THE REJECTION OF FETAL MURINE PROISLET ALLOGRAFTS AND PIG PROISLET XENOGRAFTS: COMPARISON OF INTRAGRAFT CYTOKINE mRNA PROFILES1

1999 • 35 citations

THE CYTOKINE AND HISTOLOGICAL RESPONSE IN ISLET XENOGRAFT REJECTION IS DEPENDENT UPON SPECIES COMBINATION1

1997 • 32 citations

Antigen Presentation Pathways for Immunity to Islet Transplants: Relevance to Immunoisolation

1999 • 30 citations

Chronic intravenous injections of antigen induce and maintain tolerance in T cell receptor-transgenic mice

1999 • 28 citations

The permeability of EUDRAGIT RL and HEMA-MMA microcapsules to glucose and inulin

1990 • 25 citations

Destruction of xenografts but not allografts within cell impermeable membranes.

1992 • 23 citations

Activation-induced cell death in human T cells is a suicidal process regulated by cell density but superantigen induces T cell fratricide

2002 • 17 citations

Manipulation of xenogeneic skin and/or renal graft survival in the rat-mouse concordant combination by portal vein pretransplant transfusion

1995 • 15 citations

IN VITRO XENORECOGNITION OF ADULT PIG PANCREATIC ISLET CELLS BY SPLENOCYTES FROM NONOBESE DIABETIC OR NON-DIABETES-PRONE MICE1

1998 • 13 citations

Lymphoid activation by micro-and macroencapsulated islets during mixed lymphocyte islet culture

1993 • 10 citations

RAPID REJECTION OF HLA-A2 TRANSGENIC SKIN GRAFT DUE TO INDIRECT ALLORECOGNITION1

2001 • 9 citations

Differentiation and functional maturation of human cd14+ adherent peripheral blood monocytes by xenogeneic endothelial cells: up-regulation of costimulation, cytokine generation, and toll-like receptors1

2002 • 9 citations

Therapeutic Potential of a Polymer-Encapsulated L-Dopa and Dopamine-Producing Cell Line in Rodent and Primate Models of Parkinson's Disease

1998 • 8 citations

Chemotactic Activity of Culture Supernatants of Free and Encapsulated Pancreatic Rat Islets Towards Peritoneal Macrophages

1999 • 8 citations