Do we know anything about how left–right asymmetry is first established in the vertebrate embryo?

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

2003 • 1,966 citations

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein

1998 • 1,565 citations

Hedgehog signalling in the mouse requires intraflagellar transport proteins

2003 • 1,377 citations

A Human Syndrome Caused by Immotile Cilia

1976 • 1,235 citations

Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium

2001 • 809 citations

Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse

2003 • 793 citations

A molecular pathway determining left-right asymmetry in chick embryogenesis

1995 • 781 citations

Polycystin-2 is an intracellular calcium release channel

2002 • 673 citations

Determination of left–right patterning of the mouse embryo by artificial nodal flow

2002 • 660 citations

Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut

2005 • 602 citations

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

2001 • 599 citations

Genetics and Pathogenesis of Polycystic Kidney Disease

2002 • 564 citations

Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice

1997 • 549 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left–right asymmetry

2002 • 533 citations

Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II

1999 • 524 citations

FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination

2005 • 514 citations

Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination

2005 • 466 citations

Conserved left–right asymmetry of nodal expression and alterations in murine situs inversus

1996 • 459 citations

Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A−/− Mice Analysis

1999 • 437 citations

Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

1996 • 436 citations

The Ion Channel Polycystin-2 Is Required for Left-Right Axis Determination in Mice

2002 • 429 citations

Abnormal Nodal Flow Precedes Situs Inversus in iv and inv mice

1999 • 421 citations

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination

2000 • 420 citations

The development of handedness in left/right asymmetry

1990 • 402 citations

Asymmetries in H+/K+-ATPase and Cell Membrane Potentials Comprise a Very Early Step in Left-Right Patterning

2002 • 399 citations

Loss-of-Function Mutations in a Human Gene Related to Chlamydomonas reinhardtii Dynein IC78 Result in Primary Ciliary Dyskinesia

1999 • 387 citations

Conserved function for embryonic nodal cilia

2002 • 372 citations

Morphogenesis of the murine node and notochordal plate

1994 • 332 citations

Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia

2002 • 331 citations

De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia

2005 • 307 citations

Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH

1999 • 307 citations

Axonemal Dynein Intermediate-Chain Gene (DNAI1) Mutations Result in Situs Inversus and Primary Ciliary Dyskinesia (Kartagener Syndrome)

2001 • 283 citations

Nodal activity in the node governs left-right asymmetry

2002 • 281 citations

Retinoic acid signalling links left–right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo

2005 • 269 citations

A two-cilia model for vertebrate left-right axis specification: Figure 1.

2003 • 253 citations

Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries

1999 • 219 citations

Regulation of left-right patterning in mice by growth/differentiation factor-1

2000 • 216 citations

Gap Junctions Are Involved in the Early Generation of Left–Right Asymmetry

1998 • 206 citations

Left/Right Patterning Signals and the Independent Regulation of Different Aspects ofSitusin the Chick Embryo

1997 • 206 citations

Fluid-dynamical basis of the embryonic development of left-right asymmetry in vertebrates

2004 • 188 citations

Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node

1999 • 181 citations

Activin and Its Receptors during Gastrulation and the Later Phases of Mesoderm Development in the Chick Embryo

1995 • 117 citations

Ectodermal Syndecan-2 Mediates Left-Right Axis Formation in Migrating Mesoderm as a Cell-Nonautonomous Vg1 Cofactor

2002 • 115 citations

Cell proliferation in mammalian gastrulation: The ventral node and notochord are relatively quiescent

1996 • 114 citations

Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis

2003 • 104 citations

PKCγ Regulates Syndecan-2 Inside-Out Signaling during Xenopus Left-Right Development

2002 • 95 citations

Cilia propel the embryo in the right direction

2001 • 89 citations

Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737 mutant mice

2004 • 87 citations

T<scp>he</scp> E<scp>mbryonic</scp> O<scp>rigins of</scp> L<scp>eft-</scp>R<scp>ight</scp> A<scp>symmetry</scp>

2004 • 78 citations

FGF8 Acts as a Right Determinant during Establishment of the Left-Right Axis in the Rabbit

2002 • 77 citations

Two molecular models of initial left-right asymmetry generation

1997 • 47 citations