Vasodilator Response to Systemic But Not to Local Hyperinsulinemia in the Human Forearm

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance.

1996 • 1,695 citations

The measurement of volume changes in human limbs

1953 • 1,503 citations

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

1994 • 1,200 citations

Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.

1991 • 1,073 citations

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

1990 • 938 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

Nitric oxide release accounts for insulin's vascular effects in humans.

1994 • 747 citations

Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.

1987 • 519 citations

Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM

1992 • 451 citations

Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans.

1995 • 372 citations

Insulin as a Vascular and Sympathoexcitatory Hormone

1997 • 368 citations

Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans.

1993 • 324 citations

Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans.

1994 • 287 citations

Insulin and Insulin-Like Growth Factor in Normal and Pathological Cardiovascular Physiology

1997 • 186 citations

Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects

1995 • 155 citations

Insulin-mediated vasodilation: impairment with increased blood pressure and body mass

1993 • 144 citations

The effect of the application of an arterial occlusion cuff to the wrist on the blood flow in the human forearm

1949 • 134 citations

Effect of perfusion rate on the time course of insulin-mediated skeletal muscle glucose uptake

1996 • 93 citations

Insulin resistance and vasodilation in essential hypertension. Studies with adenosine.

1994 • 91 citations

NG-monomethyl-L-arginine inhibits the blood flow but not the insulin-like response of forearm muscle to IGF- I: possible role of nitric oxide in muscle protein synthesis.

1996 • 80 citations

Insulin-Induced Sympathetic Activation and Vasodilation in Skeletal Muscle: Effects of Insulin Resistance in Lean Subjects

1995 • 73 citations

Contrasting Autonomic and Hemodynamic Effects of Insulin in Healthy Elderly Versus Young Subjects

1997 • 69 citations

Dual mechanism of insulin action on human skeletal muscle: identification of an indirect component not mediated by FFA

1991 • 18 citations

In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase. Decreased enzyme catalytic efficiency in familial hypercholesterolemia.

1987 • 15 citations

Regional Hyperinsulinemia Induces Vasodilation But Does Not Modulate Adrenergic Responsiveness in Humans

1996 • 12 citations