Regional Hyperinsulinemia Induces Vasodilation But Does Not Modulate Adrenergic Responsiveness in Humans

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

1991 • 4,548 citations

Banting lecture 1988. Role of insulin resistance in human disease

1988 • 3,751 citations

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

1994 • 1,200 citations

Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man

1981 • 1,168 citations

Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.

1991 • 1,073 citations

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

1990 • 938 citations

Nitric oxide release accounts for insulin's vascular effects in humans.

1994 • 747 citations

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

1992 • 527 citations

Measuring Forearm Blood Flow and Interpreting the Responses to Drugs and Mediators

1995 • 402 citations

Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure.

1993 • 374 citations

Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans.

1995 • 372 citations

The sympathetic response to euglycaemic hyperinsulinaemia

1992 • 296 citations

Insulin Resistance, Hyperinsulinemia, Hypertriglyceridemia, and Hypertension: Parallels Between Human Disease and Rodent Models

1991 • 286 citations

Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus

1992 • 273 citations

Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension.

1992 • 247 citations

Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans.

1992 • 207 citations

Beta adrenergic-mediated vasodilator response to insulin in the human forearm.

1985 • 188 citations

Mechanism of increased alpha adrenergic vasoconstriction in human essential hypertension.

1987 • 182 citations

Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects

1995 • 155 citations

Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines?

1990 • 114 citations

Hyperinsulinemia and the aldosterone and pressor responses to angiotensin II.

1990 • 111 citations

Effects of Insulin on Vasoconstrictive Responses to Norepinephrine and Angiotensin II in Rabbit Femoral Artery and Vein

1988 • 104 citations

Effects of Insulin on Vascular Tone and Sympathetic Nervous System in NIDDM

1996 • 101 citations

The Effect of Insulin on Vascular Reactivity to Norepinephrine

1977 • 91 citations

Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension.

1995 • 88 citations

Studies on the insulin-antagonistic effect of catecholamines in normal man

1986 • 78 citations

Intra-arterial infusion of insulin attenuates vasoreactivity in human forearm.

1993 • 67 citations

Exogenous insulin augments in healthy volunteers the cardiovascular reactivity to noradrenaline but not to angiotensin II.

1991 • 55 citations

Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans.

1993 • 55 citations

Alpha1- and alpha2-Adrenoceptor Mediated Vasoconstriction in the Forearm of Normotensive and Hypertensive Subjects

1986 • 50 citations

The effect of insulin on vascular reactivity to norepinephrine

1977 • 47 citations

Acute hyperinsulinemia induces sodium retention and a blood pressure decline in diabetes mellitus.

1992 • 44 citations

Insulin enhances pressor responses to norepinephrine in rat mesenteric vasculature.

1992 • 43 citations

Effects of insulin on vascular tone and sympathetic nervous system in NIDDM

1996 • 42 citations

Human insulin-mediated enhancement of vascular beta-adrenergic responsiveness.

1994 • 38 citations

Insulin does not reduce forearm alpha-vasoreactivity in obese hypertensive or lean normotensive men.

1993 • 37 citations

Norepinephrine-induced beta 1-adrenergic peripheral vasodilation in conscious dogs

1985 • 32 citations

Effects of insulin on vasoconstrictive responses to norepinephrine and angiotensin II in rabbit femoral artery and vein

1988 • 32 citations

The effect of noradrenaline infusions on the blood flow through the human forearm

1954 • 30 citations

Insulin and Forearm Vasodilation in Hypertension-Prone Men

1995 • 23 citations

Effects of insulin on vascular responses to mental stress and norepinephrine in human forearm.

1994 • 19 citations

Effects of Insulin on Vasoconstrictor Responses to Alpha Agonist and Tilting

1990 • 10 citations