A Comparative Analysis of the Antigenic, Structural, and Functional Properties of Three Different Preparations of Recombinant Human Interleukin-18

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

1999 • 806 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Regulation of interferon-γ production by IL-12 and IL-18

1998 • 526 citations

Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme^a

1998 • 495 citations

Overview of interleukin-18: more than an interferon-γ inducing factor

1998 • 371 citations

Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells

1999 • 368 citations

IL-18 accounts for both TNF-alpha- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice.

1997 • 325 citations

IL-18 Augments Perforin-Dependent Cytotoxicity of Liver NK-T Cells

1998 • 203 citations

Involvement of Caspase-1 and Caspase-3 in the Production and Processing of Mature Human Interleukin 18 in Monocytic THP.1 Cells

1997 • 198 citations

Studies on the molecular nature of human interleukin 1.

1987 • 186 citations

IL-1 beta is secreted by activated murine macrophages as biologically inactive precursor.

1990 • 100 citations

Interferon gamma-producing ability in blood lymphocytes of patients with lung cancer through activation of the innate immune system by BCG cell wall skeleton

2001 • 44 citations

Polymorphism and proteolytic fragments of granulocyte membrane cofactor protein (MCP, CD46) of complement

1992 • 36 citations

Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain.

1989 • 27 citations

Location of the interchain disulfide bonds of the fourth component of human complement (C4): evidence based on the liberation of fragments secondary to thiol-disulfide interchange reactions.

1986 • 19 citations

Human Macrophages Produce Dimeric Forms of IL-18 Which Can Be Detected with Monoclonal Antibodies Specific for Inactive IL-18

2001 • 11 citations

The functions of the ninth component of human complement are sustained by disulfide bonds with different susceptibilities to reduction

1994 • 9 citations

Defence procurement of dual‐use goods: Is there a single market in the European union?†

1999 • 7 citations