Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts.

Cancer statistics, 2000

2000 • 3,907 citations

Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer

2000 • 2,981 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

1997 • 841 citations

Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.

1999 • 599 citations

Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis.

2000 • 549 citations

In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.

2000 • 498 citations

Phase I Study of Anti–Epidermal Growth Factor Receptor Antibody Cetuximab in Combination With Radiation Therapy in Patients With Advanced Head and Neck Cancer

2001 • 479 citations

Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells

1990 • 465 citations

Antitumor Effects of Doxorubicin in Combination With Anti-epidermal Growth Factor Receptor Monoclonal Antibodies

1993 • 422 citations

Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.

2000 • 416 citations

The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, andmdr gene expression in colorectal cancer

1993 • 415 citations

Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin.

1995 • 391 citations

The epidermal growth factor receptor as a target for cancer therapy.

2001 • 339 citations

Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.

1999 • 335 citations

Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells.

1995 • 317 citations

Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer.

2001 • 299 citations

Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.

2000 • 228 citations

Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth.

2000 • 228 citations

A multicenter, Phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma

1999 • 201 citations

Blockade of receptors for growth factors: an anticancer therapy--the fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture.

2000 • 179 citations

Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis

2001 • 167 citations

Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice

2000 • 160 citations

Combined Modality Therapy of A431 Human Epidermoid Cancer Using Anti-EGFr Antibody C225 and Radiation

1999 • 156 citations

Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.

1990 • 149 citations

Antitumor Activity of Combined Blockade of Epidermal Growth Factor Receptor and Protein Kinase A

1996 • 141 citations

Role of an anti-epidermal growth factor receptor in treating cancer.

1999 • 128 citations

Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide.

2000 • 126 citations

Clinical relevance of transforming growth factor α, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors

1998 • 116 citations

Autonomous proliferation of colon cancer cells that coexpress transforming growth factor α and its receptor

1992 • 70 citations

Ontogeny of EGF receptors in the human gut

1999 • 64 citations

IRINOTECAN (CPT‐11): A BRIEF OVERVIEW

1996 • 42 citations

Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin

1996 • 42 citations

Transforming growth factors and related peptides in gastrointestinal neoplasia

1992 • 33 citations

Epidermal growth factor-related peptides as targets for experimental therapy of human colon carcinoma.

1998 • 31 citations

The effects of intracolonic EGF on mucosal growth and experimental carcinogenesis

1991 • 31 citations

Preclinical and Clinical Trials of Topoisomerase Inhibitors

2000 • 30 citations

Autonomous proliferation of colon cancer cells that coexpress transforming growth factor α and its receptor

1992 • 30 citations

Hepatitis delta genotypes in chronic delta infection in the northeast of Spain (Catalonia)

1998 • 30 citations

Growth modulation by epidermal growth factor (EGF) in human colonic carcinoma cells: Constitutive expression of the human EGF gene

1991 • 23 citations

The role of growth regulatory aberrations in progression of human colon carcinoma

1993 • 15 citations