Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1

2000 • 992 citations

Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

2000 • 750 citations

CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells

1997 • 662 citations

Thrombospondin‐1 as an endogenous inhibitor of angiogenesis and tumor growth

2002 • 534 citations

Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels

2002 • 494 citations

Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells.

2003 • 458 citations

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

1998 • 451 citations

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

1991 • 441 citations

Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.

2002 • 433 citations

Redefining the Target: Chemotherapeutics as Antiangiogenics

2001 • 397 citations

The cell biology of thrombospondin-1

2000 • 382 citations

RETRACTED: Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

2003 • 323 citations

Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule.

1999 • 317 citations

Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water.

2002 • 313 citations

Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells.

1997 • 295 citations

Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro.

1992 • 285 citations

Antiangiogenesis Is Produced by Nontoxic Doses of Vinblastine

1999 • 271 citations

Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.

2000 • 234 citations

Comparison of antiangiogenic activities using paclitaxel (taxol) and docetaxel (taxotere)

2003 • 220 citations

Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly

2003 • 212 citations

A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1

1998 • 184 citations

The role of MAPK pathways in the action of chemotherapeutic drugs

2002 • 178 citations

Thrombospondins and tumor angiogenesis

2001 • 173 citations

Endothelial progenitor cells as putative targets for angiostatin.

1999 • 168 citations

Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma.

2001 • 163 citations

Inhibition of tumor growth by systemic treatment with thrombospondin‐1 peptide mimetics

2002 • 130 citations

Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors.

2003 • 124 citations

Aquaporins and the respiratory system: advice for a lung investigator

2000 • 78 citations

Docetaxel induced gene expression patterns in head and neck squamous cell carcinoma using cDNA microarray and PowerBlot.

2002 • 70 citations

Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression.

1996 • 68 citations

Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells.

2001 • 64 citations

Geranylgeranyl Diphosphate-Based Inhibitors of Post-Translational Geranylgeranylation of Cellular Proteins

1996 • 36 citations

Dexamethasone inhibits Glioma-induced Formation of Capillary like Structures in vitro and Angiogenesis in vivo

1997 • 32 citations