2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.
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References (47)
Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
1973 • 12,522 citations
Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β
1997 • 4,422 citations
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
1998 • 4,127 citations
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
1994 • 2,443 citations
ERβ: Identification and characterization of a novel human estrogen receptor
1996 • 2,262 citations
Functional role of estrogen metabolism in target cells: review and perspectives
1998 • 965 citations
Superoxide dismutase as a target for the selective killing of cancer cells
2000 • 824 citations
The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth
1994 • 743 citations
The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site
1997 • 611 citations
Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.
1997 • 525 citations
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines
1999 • 475 citations
2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.
1994 • 400 citations
P450 enzymes of estrogen metabolism
1993 • 395 citations
Carcinogenicity of catechol estrogens in Syrian hamsters
1986 • 360 citations
The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors.
2001 • 333 citations
Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.
1998 • 313 citations
Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology
2000 • 292 citations
Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERRβ
2001 • 253 citations
2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate.
2000 • 235 citations
17β-Estradiol, Its Metabolites, and Progesterone Inhibit Cardiac Fibroblast Growth
1998 • 165 citations
Estradiol Metabolites Inhibit Endothelin Synthesis by an Estrogen Receptor-Independent Mechanism
2001 • 155 citations
The cytotoxic effects of estradiol-17β, catecholestradiols and methoxyestradiols on dividing MCF-7 and Hela cells
1989 • 147 citations
Impact of Continuously Administered Catechol Estrogens on Uterine Growth and Luteinizing Hormone Secretion*
1979 • 146 citations
Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol
1997 • 138 citations
Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells.
1992 • 135 citations
Hormone- and DNA-binding mechanism of the recombinant human estrogen receptor
1993 • 119 citations
The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells.
2001 • 113 citations
Growth Inhibitory Effects of Flavonoids in Human Thyroid Cancer Cell Lines
1999 • 110 citations
The mammalian metabolite, 2-methoxyestradiol, affects p53 levels and apoptosis induction in transformed cells but not in normal cells
1997 • 100 citations
Interactions of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite, with Unpolymerized Tubulin and with Tubulin Polymers
1996 • 92 citations
Synthesis of Analogs of 2-Methoxyestradiol with Enhanced Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth
1997 • 91 citations
Suppression of type II collagen‐induced arthritis by the endogenous estrogen metabolite 2‐methoxyestradiol
1997 • 90 citations
2-Methoxyestradiol-Induced Phosphorylation of Bcl-2: Uncoupling from JNK/SAPK Activation
1998 • 89 citations
An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats.
1998 • 61 citations
The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cells
2000 • 49 citations
Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta
1995 • 42 citations
Catecholestrogens inhibit proliferation and DNA synthesis of porcine granulosa cells in vitro: comparison with estradiol, 5α-dihydrotestosterone, gonadotropins and catecholamines
1989 • 41 citations
Integrated defense system overlaps as a disease model: with examples for multiple chemical sensitivity.
1998 • 40 citations
Angiostatic Treatment of Neuroblastoma
1999 • 38 citations
Oral administration of an estrogen metabolite-induced potentiation of radiation antitumor effects in presence of wild-type p53 in non–small-cell lung cancer
2000 • 34 citations
Catecholamines Abrogate Antimitogenic Effects of 2-Hydroxyestradiol on Human Aortic Vascular Smooth Muscle Cells
2001 • 33 citations
Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts
2001 • 26 citations
2-Methoxyestradiol Inhibits Longitudinal Bone Growth in Normal Female Rats
2000 • 24 citations
17β-Estradiol metabolites affect some regulators of the MCF-7 cell cycle
1996 • 24 citations
Role of estrogen receptors and antiestrogen binding sites in an early effect of antiestrogens, the inhibition of cholesterol biosynthesis
1988 • 22 citations
Use of the monoclonal antibody DAKO-ER? (8D5-1) to measure oestrogen receptor beta in breast cancer cells
2001 • 15 citations
Effects of catechol estrogen methyl ethers on lipid metabolism in prepubertal rats
1984 • 6 citations