Mutation Rate of the Hepatitis C Virus NS5B in Patients Undergoing Treatment With Ribavirin Monotherapy

Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection

2002 • 6,505 citations

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

2001 • 6,133 citations

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

2005 • 2,741 citations

Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1972 • 967 citations

RNA virus error catastrophe: Direct molecular test by using ribavirin

2001 • 819 citations

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

2000 • 812 citations

Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA

1997 • 718 citations

Rates of spontaneous mutation among RNA viruses.

1993 • 707 citations

Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.

1991 • 609 citations

Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: A multicenter trial

1997 • 384 citations

Modelling how ribavirin improves interferon response rates in hepatitis C virus infection

2004 • 367 citations

Ribavirin treatment for patients with chronic hepatitis C: results of a placebo-controlled study

1996 • 360 citations

Ribavirin as Therapy for Chronic Hepatitis C

1995 • 330 citations

Ribavirin Inhibits Viral-Induced Macrophage Production of TNF, IL-1, the Procoagulant fgl2 Prothrombinase and Preserves Th1 Cytokine Production But Inhibits Th2 Cytokine Response

1998 • 306 citations

Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children

2007 • 295 citations

The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses.

1998 • 288 citations

Prospects for Treatment of Viral Hemorrhagic Fevers with Ribavirin, a Broad-Spectrum Antiviral Drug

1989 • 287 citations

Hepatitis C Virus RNA-dependent RNA Polymerase (NS5B) as a Mediator of the Antiviral Activity of Ribavirin

2001 • 282 citations

Antiviral action of ribavirin in chronic hepatitis C

2004 • 258 citations

Effect of Ribavirin on Hepatitis C Viral Kinetics in Patients Treated With Pegylated Interferon

2003 • 253 citations

Antiviral Effect and Virus-Host Interactions in Response to Alpha Interferon, Gamma Interferon, Poly(I)-Poly(C), Tumor Necrosis Factor Alpha, and Ribavirin in Hepatitis C Virus Subgenomic Replicons

2002 • 215 citations

Transcripts of a Chimeric cDNA Clone of Hepatitis C Virus Genotype 1b Are Infectiousin Vivo

1998 • 208 citations

Viral RNA Mutations Are Region Specific and Increased by Ribavirin in a Full-Length Hepatitis C Virus Replication System

2002 • 191 citations

The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA

2003 • 177 citations

Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy

2003 • 173 citations

Ribavirin Induces Error-Prone Replication of GB Virus B in Primary Tamarin Hepatocytes

2001 • 159 citations

Identification of a Ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy

2003 • 130 citations

Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole.

1977 • 125 citations

Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C

2005 • 117 citations

Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line.

1978 • 109 citations

Detection of Anti-Hepatitis C Virus Effects of Interferon and Ribavirin by a Sensitive Replicon System

2005 • 99 citations

Ribavirin as Therapy for Chronic Hepatitis C

1995 • 95 citations

Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin

2002 • 90 citations

Ribavirin Resistance in Hepatitis C Virus Replicon-Containing Cell Lines Conferred by Changes in the Cell Line or Mutations in the Replicon RNA

2005 • 85 citations

Mutagenic and Inhibitory Effects of Ribavirin on Hepatitis C Virus RNA Polymerase

2003 • 82 citations

Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children

2004 • 72 citations

Mutations in NS5B Polymerase of Hepatitis C Virus: Impacts on in Vitro Enzymatic Activity and Viral RNA Replication in the Subgenomic Replicon Cell Culture

2002 • 52 citations

Targeting NS5B RNA-Dependent RNA Polymerase for Anti-HCV Chemotherapy

2003 • 35 citations

62 Is ribavirin antiviral effect in humans mediated by mutagenic properties resulting in error catastrophe?

2004 • 7 citations