A Polymorphism in the Tumor Necrosis Factor-α Gene Promoter Region May Predispose to a Poor Prognosis in COPD

Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study

1997 • 7,096 citations

Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation

1997 • 2,216 citations

The Electrophoretic α;₁-Globulin Pattern of Serum in α;₁-Antitrypsin Deficiency

1963 • 1,400 citations

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.

1996 • 1,370 citations

Single base polymorphism in the human Tumour Necrosis Factor alpha (TNFα) gene detectable by Ncol restriction of PCR product

1992 • 903 citations

The −308 tumor necrosis factor-α promoter polymorphism effects transcription

1997 • 868 citations

Prognosis in Chronic Obstructive Pulmonary Disease^1–3

1986 • 772 citations

An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.

1993 • 682 citations

Tumour necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans

1998 • 580 citations

Intraluminal Airway Inflammation in Chronic Bronchitis: Characterization and Correlation with Clinical Parameters

1989 • 377 citations

Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects.

1995 • 357 citations

Tumor Necrosis Factor- α Gene Polymorphism in Chronic Bronchitis

1997 • 243 citations

Altered cytokine regulation in the lungs of cigarette smokers.

1994 • 243 citations

New perspectives on basic mechanisms in lung disease. 6. Proteinase imbalance: its role in lung disease.

1993 • 141 citations

Morbidity and Mortality from Chronic Obstructive Pulmonary Disease

1989 • 65 citations

Inhibition of Mouse Alveolar Macrophage Production of Tumor Necrosis Factor Alpha by Acute in vivo and in vitro Exposure to Tobacco Smoke

1992 • 27 citations

Extracellular Proteolysis of Fibronectin by Neutrophils: Characterization and the Effects of Recombinant Cytokines

1991 • 24 citations

Polymorphism of the Tumor Necrosis Factor Genes in Patients with Dermatitis herpetiformis

1994 • 22 citations