Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies

p53 function and dysfunction

1992 • 1,918 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Metastatic Model for Human Prostate Cancer Using Orthotopic Implantation in Nude Mice

1992 • 310 citations

The Genesis and Growth of Tumors. III. Effects of a High-Fat Diet

1942 • 304 citations

Influence of Diets Containing Eicosapentaenoic or Docosahexaenoic Acid on Growth and Metastasis of Breast Cancer Cells in Nude Mice

1995 • 289 citations

Requirement of essential fatty acid for mammary tumorigenesis in the rat.

1985 • 288 citations

Biological differences among MCF-7 human breast cancer cell lines from different laboratories

1987 • 267 citations

Dietary fats and health

1984 • 263 citations

Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture.

1990 • 260 citations

Decreased Growth of Established Human Prostate LNCaP Tumors in Nude Mice Fed a Low-Fat Diet

1995 • 254 citations

Analysis of dietary fat, calories, body weight, and the development of mammary tumors in rats and mice: a review.

1990 • 237 citations

Effects of Dietary Omega-3 Fatty Acids on Human Breast Cancer Growth and Metastases in Nude Mice

1993 • 224 citations

Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines

1991 • 204 citations

Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals

1997 • 197 citations

Effect of the prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat.

1983 • 194 citations

Diet, Nutrition, and Cancer A Critical Evaluation

1985 • 189 citations

Dietary Effects of Menhaden Oil on the Growth and Membrane Lipid Composition of Rat Mammary Tumors<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1985 • 187 citations

Dietary polyunsaturated fat versus saturated fat in relation to mammary carcinogenesis

1979 • 175 citations

Effect of dietary polyunsaturated fatty acids on growth of mammary adenocarcinomas in mice and rats.

1979 • 172 citations

The p53 tumor suppressor protein, a modulator of cell proliferation.

1992 • 171 citations

Novel growth regulatory factors and tumour angiogenesis

1991 • 162 citations

Regulation of Growth and Spacing of Gland Elements in the Mammary Fat Pad of the C3H Mouse<xref ref-type="fn" rid="FN1">2</xref>

1960 • 158 citations

n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines

1994 • 156 citations

Diet and serum sex hormones in healthy men

1984 • 152 citations

Regulation of unsaturated fatty acids biosynthesis 1. Effect of unsaturated fatty acid of 18 carbons on the microsomal desaturation of linoleic acid into γ-linolenic acid

1969 • 147 citations

Dietary Fat and Mammary Cancer. I. Promoting Effects of Different Dietary Fats on <italic>N</italic>-Nitrosomethylurea-Induced Rat Mammary Tumorigenesis<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref><xref ref-type="fn" rid="FN3">4</xref>

1986 • 145 citations

Growth Factor Synthesis and Human Breast Cancer Progression

1995 • 140 citations

Dietary fatty acids and cancer

1997 • 136 citations

Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor.

1987 • 129 citations

The effects of dietary omega-3 fatty acids on the DU-145 transplantable human prostatic tumor.

1987 • 129 citations

Net Energy Effects of Dietary Fat on Chemically Induced Mammary Carcinogenesis in F344 Rats<xref ref-type="fn" rid="FN2">2</xref>

1986 • 128 citations

Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast cancer cell solid tumors growing in nude mice.

1996 • 126 citations

Effect of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice.

1993 • 125 citations

Effect of Dietary Menhaden Oil on Tumor Cell Loss and the Accumulation of Mass of a Transplantable Mammary Adenocarcinoma in BALB/c Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1986 • 124 citations

Influence of dietary fat, caloric restriction, and voluntary exercise on N-nitrosomethylurea-induced mammary tumorigenesis in rats.

1988 • 124 citations

Effects of D,L-2-difluoromethylornithine and indomethacin on mammary tumor promotion in rats fed high n-3 and/or n-6 fat diets.

1989 • 120 citations

Relationship Between Amount and Type of Dietary Fat in Promotion of Mammary Carcinogenesis Induced by 7,12-Dimethylbenz[<italic>a</italic>]anthracene<xref ref-type="fn" rid="FN2">2</xref>

1979 • 117 citations

Effect of Dietary Fat on Human Breast Cancer Growth and Lung Metastasis in Nude Mice

1991 • 116 citations

Tumor incidence in normal Sprague-Dawley female rats.

1956 • 112 citations

Effect of Dietary Fat, Antiestrogen, and Antiprolactin on the Development of Mammary Tumors in Rats2

1974 • 103 citations

Studies of genetic transmission of mammary tumour virus by C3Hf mice

1975 • 98 citations

Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus

1981 • 97 citations

Effects of dietary menhaden oil and retinyl acetate on the growth of DU 145 human prostatic adenocarcinoma cells transplanted into athymic nude mice

1988 • 94 citations

Influence of dietary fatty acids on the incidence of mammary tumors in the C3H mouse.

1981 • 93 citations

Eicosanoid synthesis in 7,12‐dimethylbenz(a)anthracene‐induced mammary carcinomas in Sprague‐Dawley rats fed primrose oil, menhaden oil or corn oil diet

1988 • 92 citations

Promotional effects of testosterone and high fat diet on the development of autochthonous prostate cancer in rats

1986 • 90 citations

Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line

1996 • 88 citations

Historical perspective: calories and energy expenditure in carcinogenesis

1987 • 88 citations

Preneoplastic lesions in murine mammary cancer.

1976 • 81 citations

Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion

1993 • 79 citations

Stimulation of growth of human breast cancer cell lines in culture by linoleic acid

1989 • 74 citations

Dietary fat, fatty acids and prostate cancer

1992 • 74 citations

The effect of the proportion of dietary fat on the rate of formation of mammary carcinoma in mice.

1950 • 73 citations

Immortalization of human mammary epithelial cells transfected with mutant p53 (273his).

1996 • 72 citations

Ability of dietary fat to overcome the resistance of mature female rats to 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis.

1980 • 71 citations

High Dietary Fat, Elevation of Rat Serum Prolactin and Mammary Cancer

1975 • 71 citations

Caloric effects in experimental mammary tumorigenesis

1987 • 65 citations

Nutrition and prostate cancer: A proposal for dietary intervention

1994 • 64 citations

Influence of dosage schedule on the biological characteristics of N-nitrosomethylurea-induced rat mammary tumors.

1980 • 63 citations

Morphogenesis and Growth Potentiality of Mammary Glands in Mice. I. Transplantability and Growth Potentiality of Mammary Tissue of Virgin Mice<xref ref-type="fn" rid="fn1">2</xref><xref ref-type="fn" rid="fn2">3</xref>

1962 • 62 citations

Simple relationships exist between dietary linoleate and the n−6 fatty acids of human neutrophils and plasma

1993 • 61 citations

Dietary linoleic acid‐stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor

1996 • 60 citations

Proliferative effects of insulin and epidermal growth factor on mouse mammary epithelial cells in primary culture. Enhancement by hydroxyeicosatetraenoic acids and synergism with prostaglandin E2.

1988 • 57 citations

Effects of fatty acids on invasion through reconstituted basement membrane (‘Matrigel’) by a human breast cancer cell line

1993 • 57 citations

Effect of varying proportions of dietary fat on the development of N-nitrosomethylurea-induced rat mammary tumors.

1986 • 49 citations

Effects of high-fat diet on the patterns of prostatic cancer induced in rats by N-nitrosobis(2-oxopropyl)amine and testosterone.

1991 • 45 citations

Eicosanoids and linoleate-enhanced growth of mouse mammary tumor cells

1991 • 44 citations

Regulation of epidermal-growth-factor-receptor signal transduction by cis-unsaturated fatty acids. Evidence for a protein kinase C-independent mechanism

1991 • 42 citations

Effects of linoleic acid and γ‐linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacityin vitro

1995 • 41 citations

Dietary Fatty Acids and Human Breast Cancer Cell Growth, Invasion, and Metastasis

1994 • 41 citations

Chemically-induced mammary gland tumors in rats: modulation by dietary fat.

1986 • 40 citations

Effects of Eicosanoid Synthesis Inhibitors on the in vitro Growth and Prostaglandin E and Leukotriene B Secretion of a Human Breast Cancer Cell Line

1995 • 39 citations

Requirement of Essential Fatty Acids in the Diet for Development of the Mouse Mammary Gland2

1980 • 37 citations

Dietary Lipid Effects on the Growth, Membrane Composition, and Prolactin-Binding Capacity of Rat Mammary Tumors<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1984 • 35 citations

Dietary fatty acids and breast cancer invasion and metastasis

1994 • 34 citations

Comparative Effects of Piroxicam and Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12-Dimethylbenz[a]anthracene in Rats on High- and Low-Fat Diets

1994 • 34 citations

Dietary fat promotes mammary tumorigenesis in MMTVv-Ha-ras transgenic mice

1993 • 34 citations

Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas.

1989 • 33 citations

Modulation in the expression of murine mammary tumor virus, ras proto-oncogene, and of alveolar hyperplasia by fatty acids in mouse mammary explant cultures.

1988 • 32 citations

Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.

1986 • 31 citations

Effects of Dietary Lipids on Lactogenic Hormone Receptor Binding in Rat Mammary Tumors<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1982 • 28 citations

Influence of Dietary Fat on the Growth of Mammary Ducts in BALB/c Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 26 citations

Influence of regional location of the inoculation site and dietary fat on the pathology of MDA-MB-435 human breast cancer cell-derived tumors grown in nude mice

1992 • 24 citations

Dietary fish oil (MaxEPA) enhances pancreatic carcinogenesis in azaserine-treated rats

1996 • 23 citations

Metabolic conversion and growth effects of n-6 and n-3 polyunsaturated fatty acids in the T47D breast cancer cell line

1996 • 23 citations

Role of estrogen and prolactin in stimulation of carcinogen-induced mammary tumor development by a high-fat diet.

1984 • 23 citations

Paracrine/autocrine growth mechanisms in tumor metastasis.

1992 • 23 citations

EFFECTS OF LINOLEIC-ACID ON MAMMARY-TUMOR CELL-PROLIFERATION ARE ASSOCIATED WITH CHANGES IN P53 PROTEIN EXPRESSION

1993 • 22 citations

Interactions between epidermal growth factor‐mediated autocrine regulation and linoleic acid‐stimulated growth of a human prostate cancer cell line

1992 • 22 citations

Preneoplastic transformation in mouse mammary tissue: identification and validation of intermediate biomarkers for chemoprevention.

1991 • 22 citations

Dietary N-3 fatty acids do not affect induction of Ha-ras mutations in mammary glands of NMU-treated rats

1991 • 20 citations

Fatty acid-induced modifications of mouse mammary alveolar lesions in organ culture

1984 • 19 citations

Effect of dietary stearic acid on the genesis of spontaneous mammary adenocarcinomas in strain A/ST mice

1984 • 18 citations

Release of arachidonic acid and its conversion to prostaglandins in various diploid cell types in culture.

1980 • 18 citations

Expression of the int-1 and int-2 loci in endogenous mouse mammary tumor virus-induced mammary tumorigenesis in the C3Hf mouse

1989 • 18 citations

Moderate changes in linoleate intake do not influence the systemic production of E prostaglandins

1985 • 17 citations

LOSS OF FATTY-ACID DELTA(6) DESATURATING ABILITY IN HUMAN MAMMARY EPITHELIAL-CELLS THAT EXPRESS AN ACTIVATED C-HA-RAS ONCOGENE

1995 • 12 citations

Dietary Effects on Gene Expression in Mammary Tumorigenesis

1995 • 7 citations

PROMOTIONAL EFFECTS OF HIGH FAT DIET ON CHEMICAL CARCINOGENESIS OF PROSTATE

1991 • 7 citations

Effect of dietary fat or tamoxifen on the expansion of cells harboring Ha-ras oncogenes in mammary glands from methylnitrosourea-treated rats

1995 • 6 citations

Interactions between estrogens, prolactin, and growth hormone on the growth of N-nitrosomethylurea-induced rat mammary tumors.

1985 • 5 citations

Demonstration of a possible link between high grade malignancy in dimethylbenz[a]anthracene-induced rat mammary carcinoma and increased urokinase plasminogen activator content

1992 • 4 citations