Transgenic gene knock-outs: functional genomics and therapeutic target selection

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

2000 • 3,436 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Drug Discovery: A Historical Perspective

2000 • 2,654 citations

The Biology of Chemokines and their Receptors

2000 • 2,416 citations

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

2000 • 1,715 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

Genome-wide, large-scale production of mutant mice by ENU mutagenesis

2000 • 681 citations

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1995 • 669 citations

Integration and Stable Germ Line Transmission of Genes Injected into Mouse Pronuclei

1981 • 665 citations

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

2000 • 661 citations

Production of gene-targeted sheep by nuclear transfer from cultured somatic cells

2000 • 624 citations

Experimental strategies for the genetic dissection of complex traits in animal models

1998 • 553 citations

Opioids: first lessons from knockout mice

1999 • 480 citations

Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides

1997 • 477 citations

Analysing complex genetic traits with chromosome substitution strains

2000 • 467 citations

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

1998 • 445 citations

Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

1999 • 435 citations

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

1993 • 428 citations

Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family

1996 • 366 citations

A candidate gene for the mouse mutation tubby

1996 • 346 citations

Genomic sciences and the medicine of tomorrow

1996 • 240 citations

High-resolution mapping of quantitative trait loci in outbred mice

1999 • 230 citations

The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs

2000 • 208 citations

In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.

2000 • 208 citations

The mouse mahogany locus encodes a transmembrane form of human attractin

1999 • 205 citations

Mouse models of human disease. Part II: recent progress and future directions.

1997 • 197 citations

Distribution and function of prostanoid receptors: studies from knockout mice

2000 • 193 citations

Sustained Long Term Potentiation and Anxiety in Mice Lacking theMas Protooncogene

1998 • 192 citations

The mahogany protein is a receptor involved in suppression of obesity

1999 • 185 citations

Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice.

1997 • 160 citations

Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells

2000 • 150 citations

Enhanced Pulmonary Allergic Responses toAspergillusin CCR2−/− Mice

2000 • 150 citations

Mouse mutants from chemically mutagenized embryonic stem cells

2000 • 147 citations

New players in the 5-HT receptor field: genes and knockouts

1995 • 126 citations

G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression

1998 • 106 citations

An action plan for mouse genomics

1999 • 100 citations

Review: Somatic Cell Nuclear Transfer in Mammals: Progress and Applications

1999 • 93 citations

Using Targeted Large Deletions and High-EfficiencyN-Ethyl-N-nitrosourea Mutagenesis for Functional Analyses of the Mammalian Genome

1997 • 85 citations

Conditional genome alteration in mice

1998 • 82 citations

Genomics and intellectual property rights

1999 • 71 citations

Sequence-based analysis of mutagenized mice

2000 • 58 citations

Transgenic mouse mutation assay systems can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens

1999 • 52 citations

Functional genomics: from genes to new therapies

1999 • 26 citations

Gene targeting, principles, and practice in mammalian cells

1999 • 23 citations

Utilization of mouse models in the discovery of human disease genes

1999 • 22 citations

Toward the yeastification of mouse genetics: chemical mutagenesis of embryonic stem cells

2000 • 22 citations

Evidence for Involvement of Prostaglandin I2 as a Major Nociceptive Mediator in Acetic Acid-Induced Writhing Reaction: a Study Using IP-Receptor Disrupted Mice

1999 • 20 citations

Muta-genetics or muta-genomics: the feasibility of large-scale mutagenesis and phenotyping programs

2000 • 19 citations

Great times for mouse genetics: getting ready for large-scale ENU-mutagenesis

2000 • 12 citations

Genomics: the race is on

1999 • 8 citations

Pass the protease: new interactions between GPCRs

2000 • 1 citations