Diagnosis of MDR-TB: a developing world problem on a developed world budget

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

1998 • 7,572 citations

Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology

1997 • 2,870 citations

Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis

1993 • 1,307 citations

Global Surveillance for Antituberculosis-Drug Resistance, 1994–1997

1998 • 816 citations

Mapping and sequencing of mutations in the Escherichia colirpoB gene that lead to rifampicin resistance

1988 • 670 citations

Antimicrobial agent resistance in mycobacteria: molecular genetic insights

1995 • 601 citations

Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot

1993 • 354 citations

Missense mutations in the catalase‐peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis

1995 • 333 citations

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis

1997 • 329 citations

Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations

1997 • 329 citations

Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level

1997 • 328 citations

Characterization of the Catalase-Peroxidase Gene (katG) and inhA Locus in Isoniazid-Resistant and -Susceptible Strains of Mycobacterium tuberculosis by Automated DNA Sequencing: Restricted Array of Mutations Associated with Drug Resistance

1996 • 319 citations

Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas

1994 • 315 citations

Mycobacterium Species Identification and Rifampin Resistance Testing with High-Density DNA Probe Arrays

1999 • 278 citations

Characterization of rifampin-resistance in pathogenic mycobacteria

1994 • 278 citations

Criteria for the control of drug-resistant tuberculosis

2000 • 246 citations

Identification of novel intergenic repetitive units in a mycobacterial two‐component system operon

1997 • 233 citations

Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms

1997 • 227 citations

Guidelines for the Management of Drug-resistant Tuberculosis

1997 • 210 citations

Detection of Kanamycin-Resistant Mycobacterium tuberculosis by Identifying Mutations in the 16S rRNA Gene

1998 • 169 citations

Novel Mutations in ndh in Isoniazid-Resistant Mycobacterium tuberculosis Isolates

2001 • 166 citations

Analysis for a Limited Number of Gene Codons Can Predict Drug Resistance of Mycobacterium tuberculosis in a High-Incidence Community

2001 • 163 citations

Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis

1995 • 155 citations

Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities

1997 • 153 citations

Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance

1994 • 151 citations

Mutations in the rpoB Gene of Rifampin-Resistant Mycobacterium tuberculosis Strains Isolated Mostly in Asian Countries and Their Rapid Detection by Line Probe Assay

1999 • 144 citations

PCR assay based on DNA coding for 16S rRNA for detection and identification of mycobacteria in clinical samples

1995 • 139 citations

Multiplex PCR assay specific for the multidrug-resistant strain W of Mycobacterium tuberculosis

1994 • 135 citations

Contribution of kasA Analysis to Detection of Isoniazid-Resistant Mycobacterium tuberculosis in Singapore

1999 • 129 citations

Outcome of chemotherapy in 107 patients with pulmonary tuberculosis resistant to isoniazid and rifampin.

1998 • 111 citations

Diagnosis of mycobacterial infections by nucleic acid amplification: 18-month prospective study

1996 • 106 citations

Simple and Rapid Identification of the Mycobacterium tuberculosis Complex by Immunochromatographic Assay Using Anti-MPB64 Monoclonal Antibodies

1999 • 105 citations

Comparison of MB/BacT ALERT 3D System with Radiometric BACTEC System and Löwenstein-Jensen Medium for Recovery and Identification of Mycobacteria from Clinical Specimens: a Multicenter Study

2001 • 97 citations

Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients

1995 • 87 citations

Mutations in the rpoB gene of Mycobacterium tuberculosis that interfere with PCR-single-strand conformation polymorphism analysis for rifampin susceptibility testing

1997 • 77 citations

Direct genotypic detection of Mycobacterium tuberculosis rifampin resistance in clinical specimens by using single-tube heminested PCR

1995 • 77 citations

Evaluation of a Bacteriophage-Based Assay (Phage Amplified Biologically Assay) as a Rapid Screen for Resistance to Isoniazid, Ethambutol, Streptomycin, Pyrazinamide, and Ciprofloxacin among Clinical Isolates of Mycobacterium tuberculosis

1999 • 70 citations

Evaluation of Reverse Transcription-PCR and a Bacteriophage-Based Assay for Rapid Phenotypic Detection of Rifampin Resistance in Clinical Isolates of Mycobacterium tuberculosis

1999 • 63 citations

Determination of hepatitis C virus genotypes in the United States by cleavase fragment length polymorphism analysis

1997 • 53 citations

Drug resistance in Mycobacterium tuberculosis strains isolated from re-treatment cases of pulmonary tuberculosis in Ethiopia: susceptibility to first-line and alternative drugs.

1998 • 51 citations

Safe Determination of Susceptibility of Mycobacterium tuberculosis to Antimycobacterial Agents by Flow Cytometry

1999 • 50 citations

Polymerase Chain Reaction for Diagnosis ofM. tuberculosis:Comparison of Simple Boiling and a Conventional Method for DNA Extraction

1996 • 46 citations

Comparison of Susceptibility Testing of Mycobacterium tuberculosis Using the ESP Culture System II with That Using the BACTEC Method

2000 • 46 citations

Epidemiology of Mycobacterium tuberculosis strains in San Francisco that do not contain IS6110.

1998 • 42 citations

Primary resistance to anti-tuberculosis drugs in Addis Ababa, Ethiopia.

1997 • 41 citations

Treatment and Implications of Multidrug-Resistant Tuberculosis for the 21st Century

1999 • 38 citations

rpoB mutations as an epidemiologic marker in rifampin-resistant Mycobacterium tuberculosis.

2000 • 34 citations

Detection of embB codon 306 mutations in ethambutol resistant Mycobacterium tuberculosis directly from sputum samples: a low-cost, rapid approach

2001 • 33 citations

Specificity of insertion sequence-based PCR assays for mycobacterium tuberculosis complex.

2001 • 32 citations

Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance inMycobacterium tuberculosis

1997 • 31 citations

Mycobacterial testing in clinical laboratories that participate in the College of American Pathologists' Mycobacteriology E survey: results of a 1993 questionnaire

1995 • 30 citations

Resistance of Mycobacterium tuberculosis to antituberculosis drugs in the Central Region of Thailand, 1996.

1998 • 30 citations

Evaluation of Etest for Susceptibility Testing of Multidrug-Resistant Isolates of Mycobacterium tuberculosis

2000 • 23 citations

Evaluation of the upgraded amplified mycobacterium tuberculosis direct test (gen-probe) for direct detection of mycobacterium tuberculosis in respiratory and non-respiratory specimens

2001 • 23 citations

Detection and diagnosis of mycobacterial pathogens using PCR

2001 • 18 citations