Endothelial Cell Oxidant Production: Effect of NADPH Oxidase Inhibitors

Biostatistical Analysis.

1975 • 10,200 citations

The American Journal of Physiology

1899 • 5,863 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

LABORATORY INVESTIGATION

1956 • 1,491 citations

Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay

1983 • 844 citations

Dichlorodihydrofluorescein and Dihydrorhodamine 123 Are Sensitive Indicators of Peroxynitritein Vitro:Implications for Intracellular Measurement of Reactive Nitrogen and Oxygen Species

1997 • 616 citations

Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives

1991 • 604 citations

The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

1986 • 551 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

1986 • 489 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs ¹

1991 • 461 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.

1994 • 349 citations

Endothelial NADPH Oxidase as the Source of Oxidants in Lungs Exposed to Ischemia or High K ⁺

1998 • 265 citations

Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils

1990 • 231 citations

Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells

1998 • 211 citations

Oxidase and Oxygenase Function of the Microsomal Cytochrome P450 Monooxygenase System

1982 • 195 citations

Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells

1998 • 188 citations

Oxidation of 2′,7′-Dichlorofluorescin by Peroxynitrite

1997 • 180 citations

NADH Oxidase Activity of Human Xanthine Oxidoreductase

1997 • 172 citations

Role of endothelial cells and their products in the modification of low-density lipoproteins

1986 • 159 citations

Inhibitory effects of phenolics on xanthine oxidase.

1994 • 157 citations

Release of hydrogen peroxide in response to hypoxia-reoxygenation: role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane.

1995 • 151 citations

Xanthine oxidase activity in rat pulmonary artery endothelial cells and its alteration by activated neutrophils.

1989 • 150 citations

Bradykinin induces superoxide anion release from human endothelial cells

1990 • 142 citations

In vitro Attenuation of Nitric Oxide Production in C6 Astrocyte Cell Culture by Various Dietary Compounds

1998 • 139 citations

Identification of a Functional Leukocyte-Type NADPH Oxidase in Human Endothelial Cells : A Potential Atherogenic Source of Reactive Oxygen Species

1999 • 138 citations

The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils

1994 • 124 citations

Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats

1991 • 118 citations

Flavonoid inhibition of the human neutrophil NADPH-oxidase

1984 • 116 citations

Inhibitors of the leukocyte superoxide generating oxidase: Mechanisms of action and methods for their elucidation

1990 • 116 citations

Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism

1992 • 104 citations

Thrombin Stimulated Reactive Oxygen Species Production in Cultured Human Endothelial Cells

1998 • 98 citations

Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits.

1992 • 95 citations

Calmodulin-dependents stimulation of the NADPH oxidase of human neutrophils

1982 • 75 citations

Inhibition of phagocytotic metabolic changes of leukocytes by an intracellular calcium-antagonist 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate

1979 • 67 citations

Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein.

1988 • 66 citations

Pyridine and imidazole reversibly inhibit the respiratory burst in porcine and human neutrophils: Evidence for the involvement of cytochrome in the reaction

1985 • 55 citations

Native low density lipoprotein. Endothelial cell recruitment of mononuclear cells.

1991 • 55 citations

Activation of the Leukocyte NADPH Oxidase by Protein Kinase C in a Partially Recombinant Cell-free System

1999 • 54 citations

Calcium and free radicals in hypoxia/reoxygenation injury of renal epithelial cells

1994 • 48 citations

Active-Site Structure Analysis of Recombinant Human Inducible Nitric Oxide Synthase Using Imidazole

1996 • 47 citations

CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells.

1997 • 47 citations

Ubiquinone content and respiratory burst activity of latex-filled phagolysosomes isolated from human neutrophils and evidence for the probable involvement of a third granule.

1983 • 46 citations

Regulation of synthesis of prostacyclin and HETEs in human endothelial cells

1989 • 45 citations

Dissociation of human neutrophil membrane depolarization, respiratory burst stimulation and phospholipid metabolism by quinacrine

1983 • 41 citations

Sulphydryl blocker induced small intestinal inflammation in rats: a new model mimicking Crohn’s disease

1997 • 37 citations

Atherogenic levels of low-density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: Possible mechanism of heightened endocytosis

1996 • 34 citations

Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells.

1992 • 28 citations

Low-Density Lipoprotein Stimulated Peroxide Production and Endocytosis in Cultured Human Endothelial Cells: Mechanisms of Action

1997 • 27 citations

Interactions of antirheumatic drugs with the superoxide generation system of activated human polymorphonuclear leukocytes.

1986 • 23 citations

Reaction products of 1-naphthol with reactive oxygen species prevent NADPH oxidase activation in activated human neutrophils, but leave phagocytosis intact

1990 • 23 citations

Inhibition of the respiratory burst and of phagocytosis by nordihydroguaiaretic acid in neutrophils

1981 • 22 citations

Selective inhibition of leukotriene C4 synthesis in human neutrophils by ethacrynic acid

1986 • 21 citations

Inhibitory effect of Cibacron Blue F3GA on the O2− generating enzyme of guinea pig polymorphonuclear leukocytes

1982 • 19 citations

Acute paw oedema formation induced by ATP: Re-evaluation of the mechanisms involved

1996 • 18 citations

The cholestatic agent, alpha-naphthylisothiocyanate, stimulates superoxide release by rat neutrophils in vitro.

1990 • 17 citations

Involvement of calcium in macrophage leukotriene release during experimental cirrhosis

1996 • 12 citations

Disulfiram is a potent inhibitor of rat 5-lipoxygenase activity

1987 • 9 citations

H1-antihistamines and calmodulin antagonists inhibit the ionophore A23187-induced eicosanoid formation by human leukocytes

1989 • 5 citations

Protein Kinase C Inhibitors Prevent Cultured Human Endothelial Cell Stress Fiber Formation, but not Heightened Endocytosis

1996 • 5 citations