The Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Cross-Talk with Hepatic Nuclear Factor 4α to Synergistically Activate the HumanCYP2C9Promoter

Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment.

1994 • 1,814 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

2001 • 1,066 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily

2001 • 627 citations

The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism

1996 • 584 citations

Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis

2003 • 548 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

2003 • 424 citations

St John's wort (Hypericum perforatum): drug interactions and clinical outcomes

2002 • 361 citations

Effects of Prototypical Microsomal Enzyme Inducers on Cytochrome P450 Expression in Cultured Human Hepatocytes

2003 • 330 citations

Induction of CYP2C genes in human hepatocytes in primary culture.

2001 • 316 citations

HNF4: A central regulator of hepatocyte differentiation and function

2003 • 281 citations

Transcriptional Regulation of CYP2C9 Gene

2002 • 260 citations

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

2003 • 218 citations

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: A study using adenovirus-mediated antisense targeting

2001 • 214 citations

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7α-hydroxylase gene transcription

2004 • 204 citations

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.

1997 • 195 citations

INDUCTION AND INHIBITION OF CYTOCHROMES P450 BY THE ST. JOHN'S WORT CONSTITUENT HYPERFORIN IN HUMAN HEPATOCYTE CULTURES

2004 • 177 citations

Regulation of HumanCYP2C9by the Constitutive Androstane Receptor: Discovery of a New Distal Binding Site

2002 • 156 citations

The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4α and cAMP-response Element-binding Protein (CREB)

2002 • 149 citations

HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A1)

2000 • 142 citations

Expression and Induction of CYP2C P450 Enzymes in Primary Cultures of Human Hepatocytes

2002 • 140 citations

Identification and functional characterization of new potentially defective alleles of human CYP2C19

2002 • 130 citations

Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance

1975 • 117 citations

Effects of erythromycin or rifampin on losartan pharmacokinetics in healthy volunteers*

1998 • 93 citations

Accessory Factors Facilitate the Binding of Glucocorticoid Receptor to the Phosphoenolpyruvate Carboxykinase Gene Promoter

2001 • 87 citations

Influence of rifampicin and isoniazid on the kinetics of phenytoin.

1985 • 86 citations

The DNA Binding Domain of Hepatocyte Nuclear Factor 4 Mediates Cooperative, Specific Binding to DNA and Heterodimerization with the Retinoid X Receptor α

1997 • 84 citations

Transcriptional Regulation of Human CYP2C Genes: Functional Comparison of CYP2C9 and CYP2C18 Promoter Regions

1995 • 79 citations

Mechanisms of liver-specific gene expression

1992 • 63 citations

Novel CAR-mediated Mechanism for Synergistic Activation of Two Distinct Elements within the Human Cytochrome P450 2B6 Gene in HepG2 Cells

2004 • 51 citations

Role of hepatocyte nuclear factor 3γ in the expression of human CYP2C genes

2004 • 50 citations

Regulation of α₁-antitrypsin gene expression in human intestinal epithelial cell line Caco-2 by HNF-1α and HNF-4

1999 • 46 citations

Transcriptional regulatory elements for basal expression of cytochrome P450IIC genes.

1992 • 39 citations

A Distal Region Involving Hepatocyte Nuclear Factor 4α and CAAT/Enhancer Binding Protein Markedly Potentiates the Protein Kinase A Stimulation of the Glucose-6-Phosphatase Promoter

2004 • 35 citations