Penumbral tissue alkalosis in focal cerebral ischemia: Relationship to energy metabolism, blood flow, and steady potential

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Pathophysiology and treatment of focal cerebral ischemia

1992 • 1,287 citations

Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.

1977 • 1,093 citations

Insulin effects on monovalent cation transport and Na-K-ATPase activity

1978 • 692 citations

Protons and Anaerobiosis

1983 • 572 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Cerebrovascular Disease: Pathophysiology, Diagnosis and Management

1998 • 386 citations

Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

1992 • 361 citations

Mitochondria in Neurodegeneration: Acute Ischemia and Chronic Neurodegenerative Diseases

1999 • 354 citations

Dynamic properties of glia cells

1979 • 344 citations

Evidence for a role of the N-methyl-d-aspartate (NMDA) receptor in cortical spreading depression in the rat

1988 • 321 citations

Extracellular pH Changes during Spreading Depression and Cerebral Ischemia: Mechanisms of Brain pH Regulation

1984 • 299 citations

Cortical Negative DC Deflections following Middle Cerebral Artery Occlusion and KCl-Induced Spreading Depression: Effect on Blood Flow, Tissue Oxygenation, and Electroencephalogram

1994 • 297 citations

The Effect of MK-801 on Cortical Spreading Depression in the Penumbral Zone following Focal Ischaemia in the Rat

1992 • 290 citations

Changes in Extra- and Intracellular pH in the Brain during and following Ischemia in Hyperglycemic and in Moderately Hypoglycemic Rats

1986 • 284 citations

Induction of Spreading Depression in the Ischemic Hemisphere following Experimental Middle Cerebral Artery Occlusion: Effect on Infarct Morphology

1996 • 251 citations

Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

1997 • 231 citations

Changes in Amino Acid Neurotransmitters and Cerebral Blood Flow in the Ischemic Penumbral Region following Middle Cerebral Artery Occlusion in the Rat: Correlation with Histopathology

1993 • 220 citations

The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury.

1997 • 214 citations

Regional changes of blood flow, glucose, and ATP content determined on brain sections during a single passage of spreading depression in rat brain cortex

1984 • 166 citations

Diffusion nuclear magnetic resonance imaging in experimental stroke. Correlation with cerebral metabolites.

1994 • 164 citations

A pictorial representation of endogenous brain ATP by a bioluminescent method

1978 • 154 citations

Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons

1998 • 143 citations

Intracellular pH in the Brain following Transient Ischemia

1983 • 136 citations

Features of Astrocytic Function Apparently Involved in the Response of Central Nervous Tissue to Ischemia-Hypoxia

1981 • 117 citations

A topographic quantitative method for measuring brain tissue pH under physiological and pathophysiological conditions

1983 • 108 citations

Ethylisopropylamiloride-sensitive pH control mechanisms modulate vascular smooth muscle cell growth

1991 • 107 citations

A Bioluminescence Method for the Demonstration of Regional Glucose Distribution in Brain Slices

1981 • 99 citations

Protective Effects of Extracellular Acidosis and Blockade of Sodium/Hydrogen Ion Exchange During Recovery from Metabolic Inhibition in Neuronal Tissue Culture

1996 • 96 citations

Elevated Lactate and Alkalosis in Chronic Human Brain Infarction Observed by ¹H and ³¹P MR Spectroscopic Imaging

1992 • 92 citations

Intracellular Brain pH, Indicator Tissue Perfusion, Electroencephalography, and Histology in Severe and Moderate Focal Cortical Ischemia in the Rabbit

1986 • 91 citations

The influence of pH on cellular calcium influx during ischemia

1994 • 90 citations

Human focal cerebral ischemia: evaluation of brain pH and energy metabolism with P-31 NMR spectroscopy.

1992 • 87 citations

Sodium-bicarbonate cotransport in retinal Muller (glial) cells of the salamander

1991 • 84 citations

Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology

1996 • 80 citations

Extracellular pH in the Brain during Ischemia: Relationship to the Severity of Lactic Acidosis

1991 • 77 citations

Regional changes in tissue pH and glucose content during cortical spreading depression in rat brain

1985 • 72 citations

Cerebral Acidosis in Focal Ischemia: II. Nimodipine and Verapamil Normalize Cerebral pH following Middle Cerebral Artery Occlusion in the Rat

1986 • 71 citations

Rat middle cerebral artery occlusion using an intraluminal thread technique

1991 • 71 citations

Cortical Impedance and Extracellular Volume Changes following Middle Cerebral Artery Occlusion in Cats

1982 • 71 citations

Correlation of local cerebral blood flow, glucose utilization, and tissue pH following a middle cerebral artery occlusion in the rat.

1985 • 70 citations

Tissue acid‐base balance and oxygen metabolism in human cerebral infarction studied with positron emission tomography

1983 • 64 citations

Monitoring the temporal and spatial activation pattern of astrocytes in focal cerebral ischemia using in situ hybridization to GFAP mRNA: comparison withsgp-2 andhsp70 mRNA and the effect of glutamate receptor antagonists

1996 • 63 citations

Regional Quantitative Determination of Lactate in Brain Sections. A Bioluminescent Approach

1985 • 60 citations

Depolarization-induced alkalinization of astrocytes in gliotic hippocampal slices

1994 • 59 citations

The influence of pH on glutamate- and depolarization-induced increases of intracellular calcium concentration in cortical neurons in primary culture

1994 • 55 citations

Changes in energy metabolites, cGMP and intracellular pH during cortical spreading depression

1994 • 44 citations

Neurologic deficit, blood flow and biochemical sequelae of reversible focal cerebral ischemia in cats

1985 • 41 citations

Chronic cerebral intracellular alkalosis following forebrain ischemic insult in rats.

1990 • 36 citations

Rebound alkalosis and persistent lactate: Multinuclear (¹H, ¹³C, ³¹P) NMR spectroscopic studies in rats

1991 • 29 citations

Cerebrovascular Disease

1989 • 29 citations

Glucose metabolism and acidosis in the metabolic penumbra of rat brain

1989 • 27 citations

Salutary and deleterious effects of acidity on an indirect measure of metabolic rate and ATP concentrations in CNS cultures

1996 • 23 citations

Effects of Intermittent Reperfusion on Brain pHi, rCBF, and NADH During Rabbit Focal Cerebral Ischemia

1995 • 20 citations

Spatial and temporal changes in tissue pH and ATP distribution in a new model of reversible focal forebrain ischemia in the rat

1993 • 13 citations