Agonist-induced desensitization of a P2Y-purinergic receptor-regulated phospholipase C

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones

1983 • 547 citations

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

1988 • 455 citations

Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.

1983 • 441 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

1985 • 332 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells.

1987 • 281 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.

1985 • 240 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

Kinetics of Activation of Phospholipase C by P2Y Purinergic Receptor Agonists and Guanine Nucleotides

1989 • 206 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.

1988 • 144 citations

Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.

1985 • 131 citations

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for .beta.-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

1986 • 125 citations

Phosphoinositide hydrolysis by guanosine 5′-[γ-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes

1988 • 106 citations

Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists

1987 • 98 citations

Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides.

1987 • 85 citations

Homologous desensitization of substance-P-induced inositol polyphosphate formation in rat parotid acinar cells

1987 • 83 citations

Receptor-specific mechanisms of desensitization of β-adrenergic receptor function

1984 • 75 citations

α‐Thrombin‐induced inositol phosphate formation in go‐arrested and cycling hamster lung fibroblasts: Evidence for a protein kinase C‐mediated desensitization response

1986 • 63 citations

Homologous desensitization of thrombin-induced phosphoinositide breakdown in hamster lung fibroblasts.

1988 • 57 citations

Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors.

1989 • 52 citations

Platelet-activating factor-induced homologous and heterologous desensitization in cultured vascular smooth muscle cells.

1988 • 38 citations

Substance P receptor desensitization requires receptor activation but not phospholipase C

1988 • 30 citations

Protein kinase C-dependent and -independent mechanisms regulating the parotid substance P receptor as revealed by differential effects of protein kinase C inhibitors

1988 • 21 citations