Lymphocyte apoptosis and apoptosis‐associated gene expression in Sjögren's syndrome

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European community

1993 • 1,438 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Regulators of cell death

1995 • 647 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Human Fas ligand: gene structure, chromosomal location and species specificity

1994 • 435 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.

1993 • 350 citations

Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.

1987 • 297 citations

The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.

1993 • 210 citations

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

1994 • 207 citations

Regulation of bcl-2 Proto-Oncogene Expression During Normal Human Lymphocyte Proliferation

1987 • 202 citations

The apoptosis-1/Fas protein in human systemic lupus erythematosus.

1994 • 200 citations

Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive & negative modulators.

1994 • 153 citations

gld/gld mice are unable to express a functional ligand for Fas

1994 • 140 citations

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.

1990 • 133 citations

Immune function in severe, active rheumatoid arthritis. A relationship between peripheral blood mononuclear cell proliferation to soluble antigens and synovial tissue immunohistologic characteristics.

1984 • 117 citations

Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes.

1990 • 112 citations

High levels of bcl‐2 protein in circulating t lymphocytes, but not b lymphocytes, of patients with systemic lupus erythematosus

1994 • 103 citations

Expression and Function of Fas Antigen and bcl-2 in Human Systemic Lupus Erythematosus Lymphocytes

1994 • 93 citations

A versatile ELISA-PCR assay for mRNA quantitation from a few cells.

1993 • 93 citations

Essential genes that regulate apoptosis

1994 • 87 citations

The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections.

1994 • 77 citations

A phorbol ester (TPA) can replace macrophages in human lymphocyte cultures stimulated with a mitogen but not with an antigen.

1982 • 73 citations

Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes.

1992 • 71 citations

Oncogene expression in autoimmune and normal peripheral blood mononuclear cells.

1986 • 65 citations

Sjögren’s Syndrome

1987 • 62 citations

Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas.

1994 • 52 citations

Apoptosis and Autoimmunity

1995 • 49 citations

Increased proto‐oncogene expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases

1986 • 49 citations

The bc1-2 Proto-Oncogene is Overexpressed in Systemic Lupus Erythematosus

1994 • 45 citations

Regulation of p26-bcl-2 protein levels in human peripheral blood lymphocytes.

1992 • 30 citations

Amplification of RNA.

1994 • 18 citations

C‐MYC proto‐oncogene expression in peripheral blood mononuclear cells from patients with primary Sjögren's syndrome

1990 • 10 citations