Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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Targeting the PI3K-Akt pathway in human cancer

2003 • 1,262 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems

2004 • 991 citations

Molecular interpretation of ERK signal duration by immediate early gene products

2002 • 914 citations

Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2

2003 • 738 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1999 • 602 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

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A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration

2003 • 324 citations

Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases

1992 • 246 citations

Bistability in the JNK cascade

2001 • 237 citations

Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity

2003 • 186 citations

ERKs, extracellular signal-regulated MAP-2 kinases

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Detection of ERK activation by a novel monoclonal antibody

1997 • 131 citations

How regulated protein translocation can produce switch-like responses

1998 • 124 citations

Stimulus-Coupled Spatial Restriction of Extracellular Signal-Regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-Response Pathways

2004 • 90 citations